Annisa Agata, 1327021010 (2015) RESPON HISTOPATOLOGIS HEPAR MENCIT (Mus musculus) YANG DIINDUKSI BENZO(α)PIREN TERHADAP PEMBERIAN TAURIN DAN EKSTRAK DAUN SIRSAK (Annona muricata). Masters thesis, Universitas Lampung.
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Abstract
ABSTRAK RESPON HISTOPATOLOGIS HEPAR MECIT (Mus musculus) YANG DIINDUKSI BENZO(α)PIREN TERHADAP PEMBERIAN TAURIN DAN EKSTRAK DAUN (Annona muricata) Oleh Annisa Agata Kanker merupakan suatu penyakit yang ditandai dengan adanya kerusakan dan ketidaknormalan sel dalam mengatur pertumbuhan dan diferensiasinya. Kanker hepar adalah gangguan pada hepar yang berawal dari tumor hepar. Taurin diketahui sebagai senyawa antioksidan, namum perannya dalam antikanker perlu dieksplorasi lebih jauh, demikian pula dengan ekstrak daun sirsak yang telah diminati oleh masyarakat sebagai bahan antikanker. Untuk itu, penelitian ini dilakukan dengan tujuan untuk mengetahui peran senyawa taurin dan ekstrak daun sirsak terhadap gambaran histopatologi hepar mencit (Mus musculus) yang terinduksi benzo(α)piren secara in vivo. Penelitian ini dilaksanakan dengan menggunakan rancangan acak lengkap (RAL) yang terdiri dari 5 kelompok perlakuan dengan masing-masing memiliki 5 ulangan. Kelompok I diberi 0,2 ml corn oil selama 15 hari, kelompok II diinduksi dengan benzo(α)piren tanpa pemberian bahan uji selama 10 hari, kelompok III pemberian taurin 7,8 mg/bb/hari (2 kali/hari) sejak 15 hari sebelum induksi benzo(α)piren), kelompok IV diinduksi benzo(α)piren dan dilanjutkan dengan pemberian taurin dosis 7,8 mg/bb/hari (2 kali/hari), kelompok V diinduksi benzo(α)piren, dilajutkan pemberian daun sirsak dosis 277,8 mg/bb/hari. Data dianalisis dengan uji Kruskal-Wallis dan one way anova serta BNT pada α 5%. Hasil menunjukkan bahwa taurin memiliki kemampuan memperbaiki kerusakan jaringan hepar yang diinduksi benzo(α)piren, sebaliknya tidak demikian dengan ekstrak daun sirsak. Kata kunci : benzo(α)piren, daun sirsak (Annona muricata), hepar, histopatologi, taurin. ABSTRACT HEPAR HISTOPATHOLOGY RESPONSE OF MICE INDUCED BY BENZO(α)PHYREN TO THE ADMINISTRATION OF TAURINE AND LEAF SOURSOP EXTRACT (Annona muricata) By Annisa Agata Cancer is a disease that is characterized by the existence of damage and cell abnormality in growth and differentiation. Liver cancer is a disorder of hepar tissue derivated from its tumors. Taurine is known as antioxidant but its role as anticancer needs to be explored more as well the role of Annona muricata leaf extract which was believed has its role as anticancer substance. This research, therefore, aimed to explore the effect of taurine and Annona muricata leaf extract on the hepar histopathology of male mice (Mus musculus) induced by benzo(α)piren in vivo. This research was carried out by using a complete randomized design, which consisted of 5 treatment groups which was repeated 5 times. Group I was given 0.2 ml corn oil for 15 days, group II was induced by benzo(α)phyren without taurine nor A. Muricata leaf extract for 10 days, group III was given 7.8 mg taurine/bw/day (twice a day) starting from the 15th days before the induction of benzo(α)phyren, group IV, after induced with benzo(α)phyren, taurine was given with dosage of 7.8 mg/bw/day, group V, after induced with benzo(α)phyren, soursop leaf extract was given with amount of 277,8 mg/bw/day). Data analyzed by Kruskal-Wallis test and one way ANOVA with Fisher test (p>0.05). The results indicated that taurine had ability to recover the liver tissue induced by benzo(α)phyren as (carcinogenic) while, Annona muricata leaf extract had not shown any recover of tissue damage. Keywords : benzo(α)phyren, hepar, histopathology, leaf soursop (Annona muricata), taurine
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | A General Works = Karya Karya Umum Q Science (General) > QH Natural history > QH301 Biology |
| Divisions: | Fakultas MIPA > Prodi Magister Ilmu Biologi |
| Depositing User: | 6662199 . Digilib |
| Date Deposited: | 24 Jun 2015 04:56 |
| Last Modified: | 09 Sep 2015 04:32 |
| URI: | http://digilib.unila.ac.id/id/eprint/10387 |
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