SINTESIS DAN KARAKTERISASI SERTA UJI PENDAHULUAN AKTIVITAS ANTIKAKER BEBERAPA SENYAWA ORGANOTIMAH(IV) 2-NITROBENZOAT TERHADAP SEL LEUKIMIA L-1210 (SINTHESIS, CHARACTHERIZATION, AND PRELIMINARY SCREENING ANTICANCER ACTIVITY OF SOME ORGANOTIN(IV) 2-NITROBENZOATE COMPOUNDS AGAINTS LEUKEMIA L-1210)

Mahmudi, Khoirul Umam (2013) SINTESIS DAN KARAKTERISASI SERTA UJI PENDAHULUAN AKTIVITAS ANTIKAKER BEBERAPA SENYAWA ORGANOTIMAH(IV) 2-NITROBENZOAT TERHADAP SEL LEUKIMIA L-1210 (SINTHESIS, CHARACTHERIZATION, AND PRELIMINARY SCREENING ANTICANCER ACTIVITY OF SOME ORGANOTIN(IV) 2-NITROBENZOATE COMPOUNDS AGAINTS LEUKEMIA L-1210). Fakultas MIPA, Universitas Lampung.

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Abstrak

Telah dilakukan sintesis senyawa dibutiltimah(IV) di-2-nitrobenzoat, difeniltimah(IV) di-2-nitrobenzoat dan trifeniltimah(IV) 2-nitrobenzoat dengan senyawa awal dibutiltimah(IV) diklorida, difeniltimah(IV) diklorida, trifeniltimah(IV) klorida, dan asam-2-nitrobenzoat. Dengan variasi waktu 3, 4, dan 5 jam diperoleh rendemen tertinggi sebesar 84,22% untuk dibutiltimah(IV) di-2-nitrobenzoat, 81,89% untuk difeniltimah(IV) di-2-nitrobenzoat, dan 85,67% untuk trifeniltimah(IV) 2-nitrobenzoat dengan waktu refluks optimum masing-masing empat (4) jam. Masing-masing senyawa hasil dengan rendemen tertinggi dikarakterisasi dengan menggunakan spektrofotometer IR, spektrofotometer UV-Vis, dan microelemental analyzer, dan dari hasil karakterisasi menunjukkan kemurnian dari senyawa hasil. Kemudian dilakukan pengujian pendahuluan aktivitas antikanker terhadap sel leukimia L-1210 diperoleh nilai IC50 untuk dibutiltimah(IV) di-2-nitrobenzoat sebesar 24,66 μg/mL, difeniltimah(IV) di-2-nitrobenzoat sebesar 9,87 μg/mL, dan trifeniltimah(IV) 2-nitrobenzoat sebesar 3,52 μg/mL. (Syntheses of dibutyltin(IV) di-2-nitrobenzoate, diphenyltin(IV) di-2-nitrobenzoate and triphenyltin(IV) 2-nitrobenzoate compounds with starting materials of dibutyltin(IV) dichloride, diphenyltin(IV) dichloride, triphenyltin(IV) chloride, and 2-nitrobenzoic acid have been performed. The time variation used were 3, 4, and 5 hours, where the highest percentage yield were 84.22% for dibutyltin(IV) di-2-nitrobenzoate, 81.89% for diphenyltin(IV) di-2-nitrobenzoate, and 85.67% for triphenyltin(IV) 2-nitrobenzoate at the optimum reflux time of four (4) hours. Each compound with the highest percent yield was characterized using IR spectrophotometer, UV-Vis spectrophotometer, and microelemental analyzer, and the results of characterization showed that the compounds synthesized were quite pure. The preliminary screening of anticancer activity against leukemia L-1210 cells was performed and the IC50 values obtained for dibutyltin(IV) di-2-nitrobenzoate, diphenyltin(IV) di-2-nitrobenzoate and triphenyltin(IV) 2-nitrobenzoate were 24.66 mg/mL, 9.87 mg/mL, 3.52 mg/mL, respectively.)

Tipe Karya Ilmiah: Skripsi
Subyek: Q Science (General) > Q Science (General)
Q Science (General) > QD Chemistry
Program Studi: Fakultas MIPA > Prodi Kimia
Depositing User: Farid Hambali Prihantoro, A.Md.
Date Deposited: 08 Jan 2014 04:50
Last Modified: 08 Jan 2014 04:50
URI: http://digilib.unila.ac.id/id/eprint/110

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