henny marlinda, 1327021007 (2015) RESPON ERITROSIT DAN LEUKOSIT MENCIT (Mus musculus) YANG DIINDUKSI BENZO(α)PIREN TERHADAP PEMBERIAN TAURIN DAN EKSTRAK DAUN DEWA Gynura segetum (Lour) Merr. Masters thesis, Universitas Lampung.
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Abstract
ABSTRAK RESPON ERITROSIT DAN LEUKOSIT MENCIT (Mus musculus) YANG DIINDUKSI BENZO(α)PIREN TERHADAP PEMBERIAN TAURIN DAN EKSTRAK DAUN DEWA (Gynura segetum (Lour) Merr Oleh Henny Marlinda Kanker darah (leukemia) merupakan salah satu penyakit kanker yang terjadi karena keganasan sel-sel darah. Pengobatan leukemia umumnya menyebabkan kerusakan pada sel-sel normal. Oleh karena itu dibutuhkan obat yang mempunyai efek memperbaiki kerusakan sel dan meningkatkan imunitas sel-sel normal seperti taurin dan daun dewa yang diduga mempunyai sifat antikanker dan antioksidan. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh taurin dan ekstrak daun dewa terhadap jaringan darah yang diinduksi benzo(α)piren secara in vivo, dengan melihat perubahan berat badan, jumlah sel darah merah (eritrosit), jumlah total dan jenis sel darah putih (leukosit) pada mencit (Mus musculus). Data dianalisis dengan one way Anova dilanjutkan uji BNT taraf nyata 5%. Kelompok perlakuan yaitu kelompok I diberi 0,2 ml minyak jagung (sebagai kontrol negatif), II (diberi benzo (α)piren sebagai kontrol positif), kelompok III (diberi taurin 7,8 mg/BB/hari dimulai sejak hari ke 1 sampai ke 15 sebelum induksi benzo(α)piren sampai akhir penelitian). Kelompok perlakuan yaitu kelompok IV diberi benzo(α)piren, selanjutnya diberi taurin 7,8 mg/BB/hari yang diberi 2 kali sehari, serta kelompok V diberi benzo(a)piren, kemudian diberi ekstrak daun dewa dosis 277,8 mg/BB/hari. Hasil penelitian menunjukkan taurin dan daun dewa mampu mencegah pembentukan sel – sel leukemia dengan meningkatkan kondisi berat badan, jumlah eritrosit, jumlah leukosit, dan jumlah macam leukosit menjadi normal kembali. Kesimpulan penelitian ini taurin mempunyai kemampuan terapoitik dan preventif, terhadap kerusakan sel-sel darah yang diinduksi benzo(α)piren serta taurin mempunyai kemampuan lebih baik dari ekstrak daun dewa . Kata kunci : benzo(α)piren, ekstrak daun dewa, taurin, eritrosit, leukosit ERYTHROCYTE AND LEUKOCYTE RESPONSES OF MICE (Mus musculus) INDUCED BY BENZO(α)PIREN TO THE ADMINISTRATION OF TAURINE AND DEWA LEAF EXTRACT Gynura segetum (Lour) Merr ABSTRACT By Henny Marlinda Blood cancer (leukemia) is a cancer that occurs due to malignancy of blood cells. Treatment of leukemia generally cause damage to normal cells. Therefore it needs a drug that has the effect on repairing cell damage and increase immunity of normal cells such as taurine and Gynura leaf expected to have anticancer and antioxidant properties. The purpose of the study is to investigate the effect of taurine and Gynura leaf extract on blood tissues induced by benzo (α) pyrene in vivo, by looking at changes in body weight, the number of red blood cells (erythrocyte), the total number and differentiation of white blood cells (leukocyte) in mice (Mus musculus). Data were analyzed by one way Anova test followed by LSD at 5% significance level. The treatment group were group I 0.2 ml of corn oil (negative control), group II (benzo (α) pyrene as a positive control), Group III (taurine 7.8 mg / BW / day starting day 1 - 15 before the induction of benzo (α) pyren in) and Group IV was given benzo (α) pyrene, the taurine 7.8 mg / BW / day 2 times a day, and the V group was given benzo (a) pyrene, and Gynura leaf extract 277.8 mg / BW / day. The results showed taurine and Gynura leaf extract were able to prevent leukemia cells by increasing body weight, erythrocyte, leukocyte, and the number of kinds of leukocyte which become normal again. In conclusion taurine has better ability therapoitic and preventive of Gynura leaf extract against blood cells induced benzo(α)piren. Keywords: benzo (α) pyrene, Gynura leaf extract, taurine, erythrocyte, leukocyte
| Item Type: | Thesis (Masters) |
|---|---|
| Subjects: | Q Science (General) > QH Natural history > QH301 Biology |
| Divisions: | Fakultas MIPA > Prodi Biologi |
| Depositing User: | 4450722 . Digilib |
| Date Deposited: | 28 Jul 2015 03:50 |
| Last Modified: | 07 Dec 2015 02:30 |
| URI: | http://digilib.unila.ac.id/id/eprint/11302 |
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