PENGARUH PEMBERIAN INFUSA KOPI LUWAK TERHADAP KADAR GLUKOSA DARAH MENCIT (Mus musculus L.) YANG DIINDUKSI ALOKSAN

Ardiansyah, 1224051013 (2015) PENGARUH PEMBERIAN INFUSA KOPI LUWAK TERHADAP KADAR GLUKOSA DARAH MENCIT (Mus musculus L.) YANG DIINDUKSI ALOKSAN. Masters thesis, Universitas Lampung.

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Abstrak

ABSTRAK PENGARUH PEMBERIAN INFUSA KOPI LUWAK TERHADAP KADAR GLUKOSA DARAH MENCIT (Mus musculus L.) YANG DIINDUKSI ALOKSAN Oleh Ardiansyah Diabetes Mellitus (DM) adalah suatu penyakit yang ditandai dengan kadar glukosa yang tinggi pada darah. Penanganan DM dapat dilakukan secara non farmakologis dan farmakologis. Berbagai obat herbal secara tradisional sudah digunakan oleh masyarakat Indonesia untuk menyembuhkan penyakit diabetes. Salah satu diantaranya adalah dengan meminum kopi secara rutin. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian infusa kopi luwak terhadap kadar glukosa darah mencit yang diinduksi aloksan dan mengetahui dosis infusa kopi luwak yang optimal dalam menurunkan kadar glukosa darah mencit yang diinduksi aloksan. Penelitian ini disusun dalam rancangan acak kelompok lengkap dengan 9 kelompok dan tiga ulangan. Satu kelompok mencit digunakan sebagai kontrol normal dan kelompok lainnya diinduksi dengan aloksan dosis 4,8 mg/g bb dan diberikan infusa kopi luwak dengan dosis 0, 6, 12, 18, 24, 30, 36, dan 42 mg/kg bb sehari sekali selama 7 hari mulai hari ke-8 pasca induksi aloksan. Hasil penelitian menunjukkan bahwa pemberian infusa kopi luwak berpengaruh nyata terhadap kadar glukosa darah mencit yang diinduksi aloksan. Pemberian infusa kopi luwak dosis 36 mg/kg bb sehari sekali selama 7 hari dapat menurunkan kadar glukosa darah menjadi normal sebesar 187 mg/dL. Kata kunci: aloksan, diabetes, glukosa darah, infusa kopi uwak ABSTRACT THE EFFECT OF CIVET COFFEE INFUSION AGAINST BLOOD GLUCOSE LEVEL IN MICE (Mus musculus L.) INDUCED ALLOXAN by Ardiansyah Diabetes Mellitus (DM) is a disease charactentized by high glucose levels in the blood. Treatment of DM can be done with non pharmacological and pharmacological. Various traditional herbal medicines have been used by the Indonesian comunity to treat of diabetic. One of them is by drinking of coffee routinely. This study airm to determine the effect of civet coffee infusion aqaints blood glucose levels in mice induced alloxan and know optimal dose of civet coffee infusion to reduce blood glucose levels in mice induced alloxan. Research arranged in a randomized block design complete with 9 groups and three replications. One group of mice was used as normal control and other mice groups were given alloxan dose of 4,8 mg/g body weight and civet coffee infusion doses of 0, 6, 12, 18, 24, 30, 36, and 42 mg/kg body weight once daily for 7 days starting day 8 post induction of alloxan. The results showed that aplication of coffee infusion gave significant effect against blood glucose levels in mice induced alloxan. Aplication of civet coffee infusiuon dose of 36 mg/kg body weight once daily for 7 days can lower blood glucose levels to normal of 187 mg/dL. Keyword: alloxan, blood glucose, civet coffee infusion, diabetic

Tipe Karya Ilmiah: Tesis (Masters)
Subyek: Agama
Hukum Pidana > Agama

Pertanian > Pertanian ( Umum )
Program Studi: Fakultas Pertanian > Prodi Magister Teknologi Industri Pertanian
Depositing User: 2425367 . Digilib
Date Deposited: 20 Aug 2015 07:51
Last Modified: 20 Aug 2015 07:51
URI: http://digilib.unila.ac.id/id/eprint/11884

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