0714061009, Indra Sofwatama (2012) PENGARUH DOSIS PEMBERIAN BRUSEIN-A YANG DIKAPSULASI LIPOSOM TERHADAP HISTOPATOLOGI GINJAL DAN HATI AYAM JANTAN TIPE MEDIUM. UNSPECIFIED.
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8. Kata Pengantar.pdf Download (79kB) | Preview |
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Abstract
Abstrak Pembuatan obat Leucocytozoonosis dengan bahan aktif brusein-A yang dikapsulasi liposom merupakan sebuah metode baru. Brusein-A yang dikapsulasi liposom dapat meningkatkan stabilitas dan aktivitas senyawa brusein-A. Penelitian ini bertujuan untuk mengetahui pengaruh dosis pemberian brusein-A yang dikapsulasi liposom terhadap gambaran histopatologi ginjal dan hati ayam jantan tipe medium. Pada penelitian ini digunakan tujuh kelompok perlakuan yaitu brusein-A yang dikapsulasi liposom pada konsentrasi 0 mg/kgBB (A1); 2,5 mg/kg BB (A2); 5,0 mg/kg BB (A3); 7,5 mg/kg BB (A4); 10,0 mg/kg BB (A5); 12,5 mg/kg BB (A6); dan 15,0 mg/kg BB (A7). Brusein-A yang dikapsulasi liposom diberikan pada ayam jantan tipe medium sehari sekali selama tujuh hari. Pengambilan organ ginjal dan hati dilakukan pada hari kedelapan dilanjutkan dengan pembuatan preparat histopatologi. Hasil penelitian menunjukkan bahwa pemberian brusein-A yang dikapsulasi liposom pada dosis kurang dari atau sama dengan 7,5 mg/kg BB sehari sekali selama tujuh hari tidak mengakibatkan kerusakan berat pada sel hati dan ginjal ayam jantan tipe medium. Abstract Leucocytozonosis drug making by using brusein-A as an active substance which is encapsulated liposome is regard as a new method. Brusein-A which is encapsulated liposome could increase stability and activity of brusein-A compound. This research aimed to determine the effect of liposome-encapsulated brusein-A exposure dosage against histopathology of medium-typed rooster’s kidney and liver. In this research, there were seven group treatments; they were brusein-A which was encapsulated by liposome in dosage: 0 mg/kg body weight (A1); 2,5 mg/kg body weight (A2); 5,0 mg/kg body weight (A3); 7,5 mg/kg body weight (A4); 10,0 mg/kg body weight (A5); 12,5 mg/kg body weight (A6); and 15,0 mg/kg body weight (A7). Brusein-A, which is encapsulated by liposome, was given to a medium-typed rooster once a day in seven days. The preparation of kidney and liver was done on the eighth day continued by the making of blood smear histopathology. The result showed that the dosage of brusein-A encapsulated liposome in less than or equals to 7,5 mg/kg body weight once a day for seven days did not lead to bad damage in medium-typed rooster’s liver and kidney.
| Item Type: | Other |
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| Subjects: | A General Works = Karya Karya Umum |
| Divisions: | Fakultas Pertanian > Prodi Peternakan |
| Depositing User: | IC-STAR . 2015 |
| Date Deposited: | 07 Sep 2015 04:06 |
| Last Modified: | 23 Oct 2015 03:51 |
| URI: | http://digilib.unila.ac.id/id/eprint/12337 |
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