HUBUNGAN STATUS ESTROGEN RECEPTOR (ER), PROGESTERON RECEPTOR (PR), DAN HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR–2 (HER–2) DENGAN DERAJAT KEGANASAN KANKER PAYUDARA DI RSUD ABDOEL MOELOEK BANDAR LAMPUNG

RIA JANITA RIDUAN , 1218011128 (2016) HUBUNGAN STATUS ESTROGEN RECEPTOR (ER), PROGESTERON RECEPTOR (PR), DAN HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR–2 (HER–2) DENGAN DERAJAT KEGANASAN KANKER PAYUDARA DI RSUD ABDOEL MOELOEK BANDAR LAMPUNG. FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.

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Abstrak

ABSTRAK Kanker payudara adalah salah satu keganasan terbanyak dan memiliki angka kematian cukup tinggi pada wanita. Tingkat keganasan kanker payudara dapat dinilai dengan derajat keganasan kanker payudara. Selain itu reseptor estrogen, reseptor progesteron dan HER–2 yang diekspresikan pada kanker payudara juga dapat memprediksi prognosis kanker secara signifikan. Penelitian ini bertujuan untuk mengetahui hubungan status reseptor estrogen, reseptor progesteron, dan HER–2 dengan derajat keganasan kanker payudara. Subjek penelitian yang digunakan adalah pasien kanker payudara yang telah diketahui derajat keganasan, status ER, PR dan HER–2 pada tahun 2014–2015 di RSUD Abdoel Moeloek Bandar Lampung yang didapatkan sebesar 54 orang. Hasil penelitian menunjukkan bahwa usia terbanyak didapatkan pada usia 41–50 tahun yaitu sebanyak 25 responden (46,3%), status ER, PR dan HER–2 terbanyak adalah negatif yaitu sebanyak 32 responden (59,3%) pada status ER dan PR, sebanyak 33 responden (61,1%) pada HER–2, sedangkan derajat terbanyak yaitu derajat 3 sebanyak 41 responden (75,9%). Hasil uji analisis Chi-Square didapatkan p<0,05 kecuali pada HER–2. Jadi dapat disimpulkan bahwa terdapat hubungan antara status reseptor ER, PR dengan derajat keganasan kanker payudara. Kata kunci: kanker payudara, derajat keganasan, estrogen receptor, progesteron receptor, HER–2 ABSTRACT Breast cancer is one of the highest malignancy and have a fairly high mortality in women. The level of malignancy of breast cancer can be judged by the degree of malignancy of breast cancer. In addition to the estrogen receptor, progesterone receptor and HER–2 that is expressed in breast cancer can also predict cancer prognosis significantly. This study aims to determine the relationship of estrogen receptor status, progesterone receptor, and HER–2 with the degree of malignancy of breast cancer. Subjects used is breast cancer patients who have known the degree of malignancy, the status of ER, PR and HER–2 in 2014–2015 in hospitals Abdoel Moeloek Bandar Lampung earned by 54 people. The results showed that the age of majority is obtained at the age of 41–50 years as many as 25 respondents (46.3%), status of ER, PR and HER–2 is the most negative as many as 32 respondents (59.3%) in the ER and PR status, a total of 33 respondents (61.1%) in HER–2, while the highest degree that is grade 3 as many as 41 respondents (75.9%). Results of the analysis of Chi–Square test was obtained p<0.05 except for the HER–2. So it can be concluded that there is a relationship between receptor status of ER, PR with the degree of malignancy of breast cancer. Keyword: breast cancer, histological grade, estrogen receptor, progesterone receptor, HER–2

Tipe Karya Ilmiah: Skripsi
Subyek: Q Science (General) > QM Human anatomy
Pengobatan > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Program Studi: Fakultas Kedokteran > Prodi Pendidikan Dokter
Depositing User: 4715265 . Digilib
Date Deposited: 27 Jan 2016 07:49
Last Modified: 27 Jan 2016 07:49
URI: http://digilib.unila.ac.id/id/eprint/20642

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