ASEP SETYA RINI , 1218011023 (2016) PENGARUH PEMBERIAN EKSTRAK METANOL DAUN KETAPANG (Terminalia catappa) TERHADAP JUMLAH FIBROBLAS PADA PENYEMBUHAN LUKA SAYAT MENCIT (Mus musculus). FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.
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Abstrak (Berisi Bastraknya saja, Judul dan Nama Tidak Boleh di Masukan)
ABSTRAK Penggunaan daun ketapang (Terminalia catappa) di Indonesia belum banyak dikenal akan manfaatnya. Daun ketapang (Terminalia catappa) memiliki manfaat mengobati sakit pinggang, gatal-gatal, kulit yang terkelupas dan luka bernanah, mengobati diare, gangguan pada saluran pencernaan, gangguan pernapasan, menurunkan tekanan darah tinggi, insomnia dan kencing darah, selain itu ekstrak daun ketapang digunakan dalam bidang kosmetik. Daun ketapang (Terminalia catappa) mengandung senyawa obat seperti saponin, tanin, dan flavonoid yang diduga memiliki efek dalam mempercepat penyembuhan luka yang ditandai dengan peningkatan jumlah fibroblas. Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak daun ketapang (Terminalia catappa) terhadap jumlah fibroblas pada penyembuhan luka sayat mencit (Mus musculus). Pada penelitian ini, 20 mencit jantan dibagi dalam 5 kelompok secara acak dan diberi perlakuan selama 7 hari. K-(kontrol negatif yang hanya diberi aquadest), K+ (kontrol positif yang diberi povidone iodine), P1 (diberi ekstrak daun ketapang 25%), P2 (diberi ekstrak daun ketapang 50%), dan P3 (diberi ekstrak daun ketapang 100%). Hasil penelitian menunjukkan bahwa ekstrak daun ketapang (Terminalia catappa) 50% dan 100% dapat meningkatkan jumlah fibroblas pada penyembuhan luka sayat mencit (Mus musculus). Hasil tersebut menunjukkan peningkatan yang signifikan terhadap kontrol positif. Kata kunci: Daun ketapang, Terminalia catappa, fibroblas, penyembuhan luka. ABSTRACT The use of Terminalia catappa leaves has not been known in Indonesia. Terminalia catappa leaves have many benefits such as a treat pain of itching, peeling skin, ulcers, diarrhea, gastrointestinal tract disorders, respiratory disorders, reduce high blood pressure, insomnia and blood urine. Besides Terminalia catappa leaves are used in the cosmetic. Terminalia catappa leaves contained drug compounds such as saponins, tannins and flavonoids that have an effect in accelerated wound healing by increased a number of fibroblasts. The purpose of this study was to determine the effect of Terminalia catappa leaves extract to fibroblast for incision wound healing in mice (Mus musculus). In this study, 20 male mice were divided randomly into 5 groups and treated for 7 days. K- (negative control which was only given distilled water), K+ (positive control which was given povidone iodine), P1 (given Terminalia catappa leaves extract 25%), P2 (given Terminalia catappa leaves extract 50%), and P3 (given Terminalia catappa leaves extract 100% ). The results showed that Terminalia catappa leaves extract 50% and 100% can increase a number of fibroblasts for incision wound healing in mice (Mus musculus). The results showed a significant increase of the positive control. Keywords: Leaves of ketapang, Terminalia catappa, fibroblasts, wound healing.
| Jenis Karya Akhir: | Skripsi |
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| Subyek: | > RS Pharmacy and materia medica |
| Program Studi: | Fakultas Kedokteran > Prodi Pendidikan Dokter |
| Pengguna Deposit: | 2916469 . Digilib |
| Date Deposited: | 27 Jan 2016 06:38 |
| Terakhir diubah: | 27 Jan 2016 06:38 |
| URI: | http://digilib.unila.ac.id/id/eprint/20643 |
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