PENGARUH EKSTRAK ETANOL KULIT MANGGIS (Garcinia mangostana L.) TERHADAP HISTOPATOLOGI PANKREAS TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR Sprague dawley YANG DIBERI PAPARAN GELOMBANG ELEKTROMAGNETIK HANDPHONE

ARISTA DEVY APRIANA, (1218011021) (2016) PENGARUH EKSTRAK ETANOL KULIT MANGGIS (Garcinia mangostana L.) TERHADAP HISTOPATOLOGI PANKREAS TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR Sprague dawley YANG DIBERI PAPARAN GELOMBANG ELEKTROMAGNETIK HANDPHONE. FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.

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Abstrak

Handphone memiliki radiasi gelombang elektromagnetik yang berbahaya bagi tubuh manusia, seperti sistem endokrin terutama sel pankreas. Untuk mengatasinya dibutuhkan senyawa antioksidan yang salah satunya terkandung dalam kulit manggis. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol kulit manggis (Garcinia mangostana L.) dapat memperbaiki gambaran histopatologi pankreas terhadap pulau langerhans tikus putih (Rattus norvegicus) galur Sprague dawley yang diberi paparan gelombang elektromagnetik handphone. Penelitian ini menggunakan 20 ekor tikus putih galur Sprague dawley yang dibagi kedalam 5 kelompok, yaitu kontrol 1 (K1) tikus yang tidak diberikan perlakuan, kontrol 2 (K2) diberikan NaCl 0,9% dan paparan gelombang elektromagnetik handphone, pada perlakuan 1 (P1), perlakuan 2 (P2) dan perlakuan 3 (P3) diberikan ekstrak etanol kulit manggis dengan dosis bertingkat 50, 100, 200 mg/kgBB dan dilakukan paparan gelombang elektromagnetik handphone selama 3 jam dalam waktu 28 hari. Data yang diperoleh dianalisis dengan menggunakan uji statistik Kruskal‒Wallis. Diperoleh K1 semua sampel normal; K2 terdapat 3 sampel kerusakan derajat 1, 1 sampel normal; P1 terdapat 1 sampel kerusakan derajat 1, 3 sampel normal; P2 terdapat 1 sampel kerusakan derajat 1, 3 sampel normal; P3 semua sampel normal. Simpulan tidak terdapat pengaruh paparan gelombang elektromagnetik terhadap histologi pankreas dan tidak terdapat pengaruh ekstrak etanol kulit manggis terhadap histopatologi pankreas yang di beri paparan gelombang elektromagnetik handphone. Kata kunci: Handphone, gelombang elektromagnetik, pankreas, kulit manggis, antioksidan ABSTRACT Handphone has the radiation of electromagnetic waves that are harmful to the human body, such as the endocrine system one of them is the pancreas.. Resolving its condition, the antioxidants contained in mangosteen peel are needed. This study aims to determine the effect of ethanol extract from mangosteen peel (Garcinia mangostana .L) in order to repair pancreas histophatological changes specifically langerhas islet cell on sprague dawley strain white male rats (Rattus norvegicus) given handphone electromagnetic exposure. This study uses 20 Sprague dawley strain white male rats with 200-300 gram body weight then the samples are divided into 5 groups which consist of Control Group 1 (K1) with no treatments are given in rats, Control 2 (K2) is given Nacl 0,9 % and mobile phone electromagnetic waves exposures. The Treatment group (P1), (P2), and (P3) are given ethanol extract from mangosteen peel with multilevel dosage of 50, 100, 200 mg / kgbw and exposure to mobile phone electromagnetic wave for 3 hours per day along for 28 days. Data were analyzed by using statistical test of Kruskal Wallis. K1 all normal sample; K2 There are 3 sample damage degrees 1, 1 normal sample; P1 There is 1 sample damage degree 1, 3 normal samples; P2 There is 1 sample damage degree 1, 3 normal samples; P3 all normal samples. Conclusion there is no influence of electromagnetic wave exposure against pancreatic histology and there is no effect of the ethanol extract of mangosteen peel against pancreatic histopathology in the given exposure to electromagnetic by handphone waves. Keywords: Handphone, electromagnetic wave, pancreas, mangosteen peel, antioksidan

Tipe Karya Ilmiah: Skripsi
Subyek: Q Science (General) > QM Human anatomy
Pengobatan > RV Botanic, Thomsonian, and eclectic medicine
Program Studi: Fakultas Kedokteran > Prodi Pendidikan Dokter
Depositing User: 1648789 . Digilib
Date Deposited: 28 Jan 2016 09:18
Last Modified: 28 Jan 2016 09:18
URI: http://digilib.unila.ac.id/id/eprint/20725

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