EFEK PROTEKTIF KITOSAN TERHADAP GAMBARAN HISTOPATOLOGI GINJAL MENCIT (Mus musculus) YANG DIINDUKSI PLUMBUM ASETAT

HANNA INSANI VEDY , 1218011066 (2016) EFEK PROTEKTIF KITOSAN TERHADAP GAMBARAN HISTOPATOLOGI GINJAL MENCIT (Mus musculus) YANG DIINDUKSI PLUMBUM ASETAT. UNIVERSITAS LAMPUNG.

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Abstrak

Plumbum merupakan logam berat yang sangat berbahaya bagi kesehatan. Angka insidensi keracunan plumbum di Indonesia masih tergolong tinggi. Keracunan plumbum dapat mengakibatkan gangguan kesehatan seperti ensefalopati, anemia, epilepsy, kerusakan otak besar, halusinasi, bahkan kerusakan ginjal. Gangguan ginjal dapat dilihat dari gambaran histopatology dengan ditemukannya gambaran fibrosis interstitialis kronis. Ekskresi plumbum di ginjal dapat mempengaruhi fungsi ginjal, menginggat ginjal merupakan suatu organ yang sangat penting untuk mengatur fungsi untuk mempertahankan volume, komposisi dan distribusi cairan tubuh serta mengeluarkan hasil metabolisme tubuh yang sudah tidak digunakan dan obat-obatan. Kerusakan pada ginjal akan berdampak pada sampah metabolisme yang tidak dapat dikeluarkan dan meracuni tubuh. Kitosan turunan kitin merupakan komponen utama dari struktur tubuh hewan golongan Crustacea, Antropoda, Annelida, Mollusca. Kitosan sebagai absorben logam berat yang dapat mengikat plumbum.Sehingga penting untuk melihat efektivitas kitosan terhadap gambaran histopatologi ginjal yang diinduksi plumbum. Metode penelitian ini merupakan eksperimental murni, dengan rancangan post test control group design. Sampel penelitian ini adalah mencit (Mus musculus L) sebanyak 25 ekor yang dipilih secara acak dibagi dalam 5 kelompok untuk dilihat gambar histopatologi ginjal. Hasil penelitian dari pengamatan didapatkan kelompok kontrol negatif hasilnya normal, kelompok kontrol positif menunjukan kerusakan derajat dua, kelompok perlakuan satu menunjukan sebagian kerusakan derajat satu dan dua, kelompok perlakuan dua dan tiga menunjukan kerusakan derajat satu. Terdapat pengaruh pemberian plumbum terhadap gambaran histopatologi ginjal dan terdapat pengaruh pemberian kitosan terhadap gambaran histopatologi ginjal yang diinduksi plumbum asetat. Kata kunci:Plumbum, Ginjal, Kitosan ABSTRACT Plumbum is a heavy metal that is harmful to health. Plumbum poisoning incidence rate in Indonesia is still relatively high. Plumbum poisoning can cause health problems such as encephalopaty, anemia, epilepsy, cerebelum demage, hallucinations and even kidney damage. Kidney disorders can be seen from the description of the histopathological finding of chronic interstitial fibrosis picture. Plumbum excretion in the kidneys may affect kidney function, considering kidney is an organ that is very important to set the function to maintain the volume, composition and distribution of body fluids as well as issuing the metabolism of the body that are not used and medicines. Damage to the kidneys will have an impact on metabolic waste that can not be removed and poison the body. The main source of pulverizing the chitosan is chitin is the main component of Crustaceagroup structure of the animal body, Arthropods, Annelid and Molluscs. Chitosan as absorbent of heavy metals that can bind plumbum. So it is important to see the effectiveness of chitosan against induced renal histopathologic picture plumbum. This research method is a purely experimental, with the design of this reserach is post test control group design. Samples were mice (Mus musculus L) as many as 25 animals were selected randomly divided into 5 groups of renal histopathology. The results of the observations obtained negative control group result is normal, positive control group showed two degrees of damage, the frist treatment group showed the most damage degree one and two, two and three treatment groups showed a degree of damage. There is the effect of giving an overview of plumbum on kidney histopathology and there is the effect of chitosan on kidney induced histopathological picture of plumbum acetate. Keywords :Plumbum, Kidney, Chitosan

Tipe Karya Ilmiah: Skripsi
Subyek: Q Science (General)
Program Studi: Fakultas Kedokteran > Prodi Pendidikan Dokter
Depositing User: 7136567 . Digilib
Date Deposited: 30 Jan 2016 03:02
Last Modified: 30 Jan 2016 03:02
URI: http://digilib.unila.ac.id/id/eprint/20728

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