PENGARUH AMNION LIOFILISASI STERIL-RADIASI (ALS-R) TERHADAP PENYEMBUHAN FRAKTUR FEMUR YANG DILAKUKAN OPEN REDUCTION INTERNAL FIXATION (ORIF) PADA TIKUS PUTIH SPRAGUE DAWLEY

Suci Widya Primadhani , 1218011151 (2016) PENGARUH AMNION LIOFILISASI STERIL-RADIASI (ALS-R) TERHADAP PENYEMBUHAN FRAKTUR FEMUR YANG DILAKUKAN OPEN REDUCTION INTERNAL FIXATION (ORIF) PADA TIKUS PUTIH SPRAGUE DAWLEY. FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.

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Abstrak

ABSTRAK Penatalaksanaan fraktur dengan metode Open Reduction Internal Fixation (ORIF) memiliki kekurangan berupa risiko tinggi infeksi, non union, kegagalan implantasi dan refraktur. Amnion Liofilisasi Steril-Radiasi (ALS-R) telah diketahui memiliki growth factor dan cell scaffold yang dapat berperan dalam penyembuhan fraktur. Penelitian ini dilakukan untuk mengetahui pengaruh penambahan ALS-R pada ORIF secara histopatologi pada proses penyembuhan fraktur femur pada tikus. Penelitian ini melibatkan 30 tikus Sprague Dawley. Sampel dibagi menjadi 3 kelompok yakni fraktur (K), fraktur yang dilakukan ORIF (P1) dan fraktur yang dilakukan ORIF dengan penambahan ALS-R (P2). Setelah 28 hari tikus diterminasi dan diambil jaringan tulang femur yang diamati secara histopatologi dengan menggunakan skoring Salked. Penelitian ini menggunakan analisis non-parametrik Kruskal-Wallis dan post hoc MannWhitney. Terdapat perbedaan yang bermakna secara statistik skor histopatologi penyembuhan fraktur antara ketiga kelompok penelitian (p<0,05). Perbandingan rata-rata skor histopatologi pada kelompok P2 dan P1 menunjukkan tidak terdapat perbedaan yang signifikan (p>0,05), namun rata-rata skor histopatologi lebih tinggi pada kelompok P2 dibandingkan dengan kelompok P1. ALS-R memberikan pengaruh positif terhadap penyembuhan fraktur femur tikus putih Sprague Dawley. Kata kunci: Penyembuhan fraktur, ORIF, ALS-R ABSTRACT Fracture treatment with Open Reduction Internal Fixation (ORIF) method has some weaknesses such as high risk infection, non union, implantation failed, and refracture. Lyophilized Radiation Sterilized Amnion Membrane (ALS-R) known that has some growth factors and cells scaffold which play role in fracture healing. This study aims to know the role of giving ALS-R in ORIF histopathologically in fracture femur healing process in rats.This study is involving 30 Sprague Dawley rats. Samples divided into three groups, whic is fracturized (K), fracturized and immobilized with ORIF (P1), and fracturized then immobilized with ORIF and given ALS-R (P2). After 28 days samples were terminated and took for its femur and analized histopathologically using Salked score. Data were analized with Kruskal-Wallis test and post hoc Mann-Whitney. This study results a statistically different histopathologic fracture healing between three groups (p<0,05). Comparison the means of P2 and P1 showed there was no significance difference, how ever the means of P2 is higher than P1. ALS-R has a positive impact toward fracture femur healing in Sprague Dawley rats. Keyword: Fracture healing, ORIF, ALS-R

Tipe Karya Ilmiah: Skripsi
Subyek: Pengobatan > RB Pathology
Pengobatan > RD Surgery
Depositing User: 8582106 . Digilib
Date Deposited: 30 Jan 2016 03:09
Last Modified: 30 Jan 2016 03:09
URI: http://digilib.unila.ac.id/id/eprint/20735

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