ANALISIS PERBANDINGAN UJI SENSITIVITAS ANTIBIOTIKA DAN KEBERADAAN EXTENDED SPECTRUM BETA LACTAMASE(ESBL) PADAEscherichia coli DARI FESES TENAGA MEDIS DI RUANG RAWAT INAP DEWASA DAN RUANG RAWAT INAP ANAK RSUD.DR.H.ABDUL MOELOEK PROVINSI LAMPUNG

HERA JULIA GARAMINA, 1218011070 (2016) ANALISIS PERBANDINGAN UJI SENSITIVITAS ANTIBIOTIKA DAN KEBERADAAN EXTENDED SPECTRUM BETA LACTAMASE(ESBL) PADAEscherichia coli DARI FESES TENAGA MEDIS DI RUANG RAWAT INAP DEWASA DAN RUANG RAWAT INAP ANAK RSUD.DR.H.ABDUL MOELOEK PROVINSI LAMPUNG. Kedokteran, Universitas Lampung.

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Abstrak

ABSTRAK ANALISIS PERBANDINGAN UJI SENSITIVITAS ANTIBIOTIKA DAN KEBERADAAN EXTENDED SPECTRUM BETA LACTAMASE ( ESBL ) PADA Escherichia coli DARI FESES TENAGA MEDIS DI RUANG RAWAT INAP DEWASA DAN RUANG RAWAT INAP ANAK RSUD.DR.H.ABDUL MOELOEK PROVINSI LAMPUNG Oleh HERA JULIA GARAMINA Latar Belakang: Infeksi nosokomial adalah infeksi yang angka mortalitas dan morbiditas tinggi di dunia, disebabkan oleh bakteri gram negatif. Sebagaian besar dari bakteri Gram negatif memiliki karakteristik sebagai bakteri penghasil Extended Spectrum Beta Lactamase ( ESBL ) merupakan suatu enzim yang dapat menghidrolisis dan menginaktivasi berbagai cincin betalaktam pada antibiotika golongan beta laktam. Tujuan penelitian adalah untuk mengetahui perbandingan uji sensitivitas dan ESBL yang dihasilkan bakteri Escherichia coli dari sampel feses tenaga medis di ruang rawat inap dewasa dan anak RSUD Abdul Moeloek Lampung. Metode penelitian: desain penelitian yang digunakan adalah analitik komparatif dengan pendekatan cross sectional. Populasi penelitian adalah tenaga medis di ruang rawat inap dewasa dan anak sampel berjumlah 64 sampel menggunakan teknik yaitu stratified disproportionate sampling. Sampel feses diambil sebanyak 1 gram, kemudian dilarutkan ke dalam Brain Heart Infusion ( BHI ) Hasil penelitian: Hasil penelitian didapatkan 22 bakteri E. Coli yang ditemukan di feses. Tidak ada perbedaan bermakna antara E. coli yang ditemukan di ruang rawat inap dewasa dan anak dengan uji kepekaan antibiotika amoksisilin, ampicilin, cefadroxil, cefuroxime dan sulfametoxazol dengan p value > 0,05. Kesimpulan: Hasil yang didapatkan dari pemeriksaan uji konfirmasi dari 22 sampel E. coli adalah ESBL negatif. Sehingga tidak dapat dihitung secara statistika. Kata Kunci : antibiotika beta laktam, esbl, e. coli, infesksi nosokomial. ABSTRACT COMPARISON ANALYSIS OF THE ANTIBIOTIC SENSITIVITY TEST AND EXTENDED SPECTRUM BETA LACTAMASE ( ESBL ) IN Escherichia coli FROM THE FECES OF MEDICAL PERSONNEL IN ADULT INPATIENT UNIT AND CHILDREN INPATIENT UNIT RSUD.DR.ABDUL MOELOEK LAMPUNG By HERA JULIA GARAMINA Background: Nosocomial infection is an infectious disease which has a high mortality and morbidity rates in the world. Most of Gram-negative bacteria have characteristics as bacteria Extended Spectrum Beta lactamase ( ESBL ) is an enzyme that can hydrolyze and inactivate various beta-lactam ring at the betalactam class of antibiotics. The aim of this study was to compare antibiotic sensitivity test and the presence of Extended Spectrum Beta lactamase ( ESBL ) produced by Escherichia coli bacteria from samples of medical staff in adult room and children room RSUD.DR. Abdul Moeloek Lampung. Methods: This research method is comparative analytic with cross sectional approach. Population in this study was all medical staff in adult room and children room RSUD.DR. Abdul Moeloek. There was 64 samples taken from populatin and using a sampling technique that is disproportionate stratified sampling. Feses are taken as much as 1 gram, then dissolved into Brain Heart Infussion ( BHI ) . Result: The result showed that as many as 22 Escherichia coli bacteria found in feces medical staff. There is no significant difference between the E. coli found in adult and children room with sensitivityantibiotic amoxicillin, ampicillin, cefadroxil, cefuroxime and sulfametoxazol with p value > 0.05. Conclusion: The results obtained from the examination of the confirmation test of 22 samples of E. coli taken from feces nurses are negative ESBL. So it can not be computed using statistical test. Keywords : beta lactam antibiotics, esbl, e. coli , nosocomial infection.

Tipe Karya Ilmiah: Skripsi
Subyek: Q Science (General)
Program Studi: Fakultas Kedokteran > Prodi Pendidikan Dokter
Depositing User: 5198206 . Digilib
Date Deposited: 29 Jan 2016 07:26
Last Modified: 29 Jan 2016 09:05
URI: http://digilib.unila.ac.id/id/eprint/20754

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