AIRI FIRDAUSIA KUDSI , 1218011006 (2016) PERBANDINGAN EFEK PEMBERIAN DOSIS MAKSIMUM AMOKSISILIN GENERIK BERLOGO DAN AMOKSISILIN GENERIK BERMEREK TERHADAP KADAR GLUTATION GINJAL Rattus norvegicus GALUR Sprague Dawley. FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.
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Abstrak (Berisi Bastraknya saja, Judul dan Nama Tidak Boleh di Masukan)
Penggunaan obat antibiotik yang semakin meningkat dapat menimbulkan masalah kesehatan di Indonesia. Amoksisilin adalah antibiotik beta-laktam yang berspektrum luas dan banyak digunakan masyarakat. Amokisisilin akan dimetabolisme di hati dan diekskresi melalui ginjal. Tujuan penelitian ini adalah untuk mengetahui perbedaan efek pemberian amoksisilin generik berlogo dan amoksisilin generik bermerek dosis maksimum terhadap kadar glutation ginjal. Penelitian ini merupakan penelitian eksperimental dengan desain post test only control group. Penelitian ini menggunakan tikus (Rattus norvegicus) galur Sprague Dawley. Tikus diberikan amoksisilin generik berlogo dan generik bermerek pada dosis 102,8 mg/kgbb, 205,6 mg/kgbb, dan 411,2 mg/kgbb. Kadar glutation ginjal diukur menggunakan metode Ellman. Digunakan reagen asam ditionitrobenzoat (DTNB) dan serapan diukur dengan spektrofotometri. Kurva standar didapatkan dari regresi linear terhadap larutan standar. Persamaan kurva standar yang digunakan dalam penelitian ini adalah y=250,9x – 2.3241. Kadar glutation dihitung dengan memasukkan nilai serapan ke dalam persamaan tersebut. Kemudian dilakukan uj statistik one way ANOVA untuk mengetahui hubungan antara dosis amoksisilin dengan kadar GSH. Berdasarkan hasil penelitian, terdapat perbedaan kadar glutation ginjal antara tikus yang diberikan amoksisilin generik bermerek dengan generik berlogo pada dosis 102,8 mg/kgbb dan 205,6 mg/kgbb dan terjadi penurunan kadar glutation ginjal tikus yang diberikan amoksisilin generik berlogo maupun generik bermerek. Kata kunci: amoksisilin, glutation, xenobiotik ABSTRACT Increasing amoxicillin use can inflict health problems in Indonesia. Amoxicillin is a beta-lactam broad-spectrum antibiotics and it is used extensively between society. Amoxicillin is metabolized in the liver and excreted through the kidneys. The purpose of this study is to know the difference of the effect of maximum dose generic and branded amoxicillin administration toward kidney glutathione level. This is an experimental study with post test only control group design. The study used Sprague Dawley rats (Rattus norvegicus). Rats was given generic amoxicillin and branded amoxicillin with dose of 102,8 mg/kgbw, 205,6 mg/kgbw and 411,2 mg/kgbw. Kidney glutathione levels was measured using the Ellman method. Reagent dithionitrobenzoic acid was used and the absorbancy was measured using spectrofotometry. Standard curve was acquired from linear regression of standard solution. Standard curve equation used in this study is y=250,9x-2.3241. Kidney glutathione levels was calculated by inputting the absorbancy to the equation. Then one way ANOVA statistical test was performed to know the correlation between amoxicillin dose and GSH levels. Based on this study, there is a difference of the effect of maximum dose generic and branded amoxicillin administration toward kidney glutathione level in dose 102,8 mg/kgbw and 205,6 mg/kgbw and there is a decrease to kidney glutathione levels of rats administered with generic amoxicillin as well as branded amoxicillin Key words: Amoxicillin, glutathione, xenobiotics
| Jenis Karya Akhir: | Skripsi |
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| Subyek: | > RM Therapeutics. Pharmacology |
| Program Studi: | Fakultas Kedokteran > Prodi Pendidikan Dokter |
| Pengguna Deposit: | 7761526 . Digilib |
| Date Deposited: | 04 Feb 2016 07:42 |
| Terakhir diubah: | 04 Feb 2016 07:42 |
| URI: | http://digilib.unila.ac.id/id/eprint/20870 |
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