BOBI KURNIA HARTANTO , 1218011028 (2016) PENGARUH MADU BEE POLLEN TERHADAP GAMBARAN HISTOPSTOLOGI HEPAR TIKUS PUTIH JANTAN RATTUS NOVERGICCUS GALUR SPRAGUE DAWLEY YANG DIINDUKSI IBUPROFEN. FAKULTAS KEDOKTERAN , UNIVERSITAS LAMPUNG.
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Abstrak (Berisi Bastraknya saja, Judul dan Nama Tidak Boleh di Masukan)
ABSTRAK Tubuh kita memerlukan substansi penting yaitu antioksidan yang dapat melindungi tubuh dari serangan radikal bebas. Antioksidan tersebut terdapat pada madu Bee pollen yang mengandung fenol yang dapat mengobati hepar yang telah terinduksi ibuprofen. Ibuprofen memiliki sifat racun bagi hepar sehingga butuh suatu antioksidan untuk melindungi bahkan mengobati hepar yang telah diinduksi ibuprofen sebagai hepatotoksik. Kerusakan hepar disini diukur dari jumlah sel hepar yang mengalami bengkak keruh untuk melihat tingkat kerusakan dari hepar terseut dan dosis yang efektif dalam mengobati hepar yang telah diinduksi ibuprofen. Dalam penelitian ini terdapat 24 sampel yang menjadi 4 kelompok. Kelompok A adalah kontrol normal Hasil penelitian ini menunjukkan terdapat pengaruh madu Bee pollen terhadap gambaran histopatologi hepar tikus putih rattus novergiccus galur Sprague dawley yang diinduksi ibuprofen.. Kata kunci: Bee pollen, fenol, ibuprofen, hepar ABSTRACT Our body need an important substace which is antioksidant that can protect it from a free radicals. Antioxidant can be found in Bee pollen honey that contains fenol that can heal hepar that inducted by ibuprofen. Ibuprofen has a poison to hepar that needs antioxidant to protecct even heal hepar that has inducted by ibuprofen as hepatotoxic. A hepar damage here is counted by the amount of hepar cells that turbid- swollen to see the damage rate or hepar and the evective dose to heal hepar thar has inducted by ibuprofen. In this study there were 24 samples that divided into 4 groups. Group A is the normal control (distilled ibuprofen). Group B is negative control (ibuprofen and distilled Bee pollen honey half of the recommended dose (0,77 mL/kg’s rat). Group C were induced by ibuprofen and Bee pollen honey with recommended dose (1,54 mL/kg’s rat). Group D were given ibuprofen and Bee pollen honey with the higher dose (2,08 mL/kg’s rat). Treatment was given for 14 days. Termination was doneby anesthesia thatused ketamine-xylazineintaperitoneal, then euthanasia by cervical dislocation method, after that hepar was taken and slide was made with hematoxylin-eosin (HE). The results show an effect of Bee pollen honey on histopathology imaging of Sprague Dawley strain white rat’s hepar that induced by ibuprofen. Keywords: Bee pollen, fenol, ibuprofen, hepar
| Jenis Karya Akhir: | Skripsi |
|---|---|
| Subyek: | > R Medicine (General) > RA Public aspects of medicine |
| Program Studi: | Fakultas Kedokteran > Prodi Pendidikan Dokter |
| Pengguna Deposit: | 8761656 . Digilib |
| Date Deposited: | 18 Apr 2016 06:14 |
| Terakhir diubah: | 18 Apr 2016 06:14 |
| URI: | http://digilib.unila.ac.id/id/eprint/21729 |
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