PENGARUH INDUKSI PLUMBUM ASETAT TERHADAP MEMORI KERJA PADA TIKUS PUTIH JANTAN (Rattus norvegicus)GALUR Sprague dawley

Azrie Izzatul Jannah, 1318011030 (2017) PENGARUH INDUKSI PLUMBUM ASETAT TERHADAP MEMORI KERJA PADA TIKUS PUTIH JANTAN (Rattus norvegicus)GALUR Sprague dawley. Fakultas kedokteran, Universitas Lampung.

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Abstrak

ABSTRACT THE EFFECT OF LEAD ACETATE INDUCTION TOWARDS WORKING MEMORY OF MALE RAT ( Rattus novergicus ) STRAINS Sprague dawley By Azrie Izzatul Jannah Background: Besides developing economic sector, industrial development in Indonesia could results in environment pollution. One of the industrial residual product is lead. Lead is one kind of heavy metal and neurotoxic which could causing impairment of working memory. This study aims to determine the effect of lead acetate induction towards working memory of male rat ( Rattus novergicus ) strains Sprague dawley. Methods: This study used 24 male rats ( Rattus norvegicus ) strains Sprague dawley aged 2-3 months that were divided into 4 groups induced by lead acetate for 7 days. The control group ( K ) that does not get induced by lead acetate, group 1 induced by 50 mg/kg lead acetate ( P1) , group 2 induced by 100 mg/kg lead acetate ( P2) , and group 3 induced by 200 mg/kg lead acetate ( P3) . Working memory assessed using Radial Arm Maze with prior exercise 2 times for 2 days. The results were counted as percentage of correct choices as the number of arms and analyzed using Kruskal Wallis test. Results: The results of the average number of working memories are K: 79.1%, P1: 62.5%, P2: 60.4%, P3: 45.8%. The result obtains significant influence with p value=0.010. Conclusion: Induction of lead acetate affecting the working memory of male rat ( Rattus norvegicus ) strains Sprague dawley. Keywords: Lead, Radial Arm Maze, Working Memory ABSTRAK PENGARUH INDUKSI PLUMBUM ASETAT TERHADAP MEMORI KERJA PADA TIKUS PUTIH JANTAN ( Rattus norvegicus ) GALUR Sprague dawley Oleh Azrie Izzatul Jannah Latar belakang: Perkembangan industri di Indonesia selain mengembangkan sektor ekonomi juga dapat memberikan dampak negatif seperti pencemaran lingkungan. Salah satu produk sampingan pabrik yang mencemari lingkungan adalah plumbum. Plumbum merupakan logam berat dan neurotoksik yang dapat menurunkan memori kerja. Penelitian ini bertujuan untuk mengetahui pengaruh induksi plumbum asetat terhadap memori kerja tikus putih jantan ( Rattus novergicus ) galur Sprague-dawley. Metode: Penelitian ini menggunakan 24 ekor tikus putih ( Rattus norvegicus ) jantan galur Sprague-dawley berusia 2-3 bulan terbagi ke dalam 4 kelompok yang diinduksi dengan plumbum asetat selama 7 hari, yaitu kelompok kontrol ( K ) , kelompok perlakuan 1 dosis 50 mg/kg ( P1) , kelompok perlakuan 2 dosis 100 mg/kg ( P2) dan kelompok perlakuan 3 dosis 200 mg/kg ( P3) . Memori kerja dinilai menggunakan alat Radial Arm Maze dengan latihan 2 kali selama 2 hari. Data yang didapatkan merupakan persentase jumlah lengan yang benar dimasuki tikus dan dianalisis menggunakan uji Kruskal Wallis. Hasil penelitian: Hasil rerata nilai memori kerja pada K: 79,1%, P1: 62,5%, P2: 60,4%, P3: 45,8% didapatkan pengaruh yang bermakna dengan nilai p=0.010. Simpulan: Induksi plumbum asetat dapat mempengaruhi memori kerja tikus putih ( Rattus norvegicus ) jantan galur Sprague-dawley. Kata kunci: Memori Kerja, Plumbum, Radial Arm Maze

Tipe Karya Ilmiah: Skripsi
Subyek: Q Science (General) > Q Science (General)
Program Studi: Fakultas Kedokteran > Prodi Pendidikan Dokter
Depositing User: 3815513 . Digilib
Date Deposited: 20 Apr 2017 07:12
Last Modified: 20 Apr 2017 07:12
URI: http://digilib.unila.ac.id/id/eprint/26305

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