SINTESIS, KARAKTERISASI, DAN UJI PENDAHULUAN SENYAWA TURUNAN TRIFENILTIMAH(IV) BENZOAT SEBAGAI ANTIMALARIA

Della Mita Andini, 1317011011 (2017) SINTESIS, KARAKTERISASI, DAN UJI PENDAHULUAN SENYAWA TURUNAN TRIFENILTIMAH(IV) BENZOAT SEBAGAI ANTIMALARIA. FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM, UNIVERSITAS LAMPUNG.

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Abstrak

Sintesis senyawa trifeniltimah(IV) 4-klorobenzoat dan trifeniltimah(IV) 4- hidroksibenzoat telah berhasil dilakukan. Sintesis diawali dengan mereaksikan senyawa antara trifeniltimah(IV) hidroksida dengan ligan karboksilat yaitu asam 4-klorobenzoat dan asam 4-hidroksibenzoat dalam pelarut metanol dengan perbandingan mol 1:1. Kedua senyawa yang diperoleh berupa serbuk berwarna putih dengan rendemen masing-masing 98,89% dan 92,40%. Senyawa hasil sintesis telah divalidasi menggunakan spektrofotometer UV-Vis, IR, spektrometer NMR dan microelemental analyzer. Senyawa hasil sintesis selanjutnya diuji aktivitas antimalarianya terhadap parasit Plasmodium falciparum strain 3D7 secara in vitro. Hasil pengujian menunjukkan bahwa trifeniltimah(IV) 4- klorobenzoat dan trifeniltimah(IV) 4-hidroksibenzoat berpotensi sebagai obat malaria namun kedua senyawa tersebut kurang efektif jika dibandingkan dengan klorokuin. Kata Kunci : antimalaria, Plasmodium falciparum, turunan trifeniltimah(IV)benzoat ABSTRACT Synthesis of triphenyltin(IV) 4-chlorobenzoate and triphenyltin(IV) 4- hydroxybenzoate has been successfully performed. Synthesis was commenced by reacting the triphenyltin(IV) hydroxyde intermediates with the carboxylate ligands as 4-chlorobenzoic acid and 4-hydroxybenzoic acid in methanol with ratio 1:1. Both of the compounds were produced as white solid the yield of 98.89% and 92.40%, respectively. The yields were validated using UV-Vis, infrared spectrophotometer, NMR spectrometer and microelemental analyzer. The synthesized compounds were tested of the antimalarial activity towards Plasmodium falciparum strain 3D7 parasite. Preliminary test result showed that the triphenyltin(IV) 4-chlorobenzoate and triphenyltin(IV) 4-hydroxybenzoate were potential as malarial drugs but they were less effective than chloroquine. Keyword: antimalarial, Plasmodium falciparum, triphenyltin(IV) benzoate derivatives

Tipe Karya Ilmiah: Skripsi
Subyek: Q Science (General) > Q Science (General)
Program Studi: Fakultas MIPA > Prodi Kimia
Depositing User: 33496560 . Digilib
Date Deposited: 14 Jun 2017 06:01
Last Modified: 14 Jun 2017 06:01
URI: http://digilib.unila.ac.id/id/eprint/26870

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