RADELLA HERVIDEA , 1627021001 (2018) EFEK EKSTRAK METANOL MAKROALGA COKELAT (Sargassum sp.), MAKROALGA MERAH (Gracillaria sp.) DAN TAURIN TERHADAP GAMBARAN HISTOPATOLOGI HEPAR DAN GINJAL MENCIT JANTAN (Mus musculus L.) YANG DIINDUKSI BENZO(Α)PIREN. Masters thesis, UNIVERSITAS LAMPUNG.
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Abstrak (Berisi Bastraknya saja, Judul dan Nama Tidak Boleh di Masukan)
Kanker merupakan suatu penyakit yang ditandai dengan adanya pertumbuhan abnormal sel secara terus menerus dan tidak terkendali pada jaringan tubuh suatu organisme. Benzo(α)piren adalah salah satu zat yang dapat menyebabkan kanker. Ekstrak dari makroalga cokelat dan makroalga merah memiliki aktivitas antikanker dan antioksidan. Senyawa lain yang berfungsi sebagai antioksidan adalah taurin. Tujuan dari penelitian ini adalah menguji efek dari ekstrak makroalga dan taurin terhadap gambaran histopatologi hepar dan ginjal mencit (Mus musculus) yang diinduksi benzo(α)piren. Penelitian ini menggunakan Rancangan Acak Lengkap (RAL). Sebanyak 30 ekor mencit jantan dibagi ke dalam 6 kelompok perlakuan yaitu : K1 = (K-), K2= benzo(α)piren 10 hari, K3= benzo(α)piren 10hari kemudian ekstrak makroalga cokelat 8 mg/ekor/hari selama 15 hari, K4= benzo(α)piren 10 hari kemudian ekstrak makroalga merah 8 mg/ekor/hari selama 15 hari , K5 = benzo(α)piren 10hari kemudian kombinasi ekstrak makroalga cokelat 8 mg/ekor/hari dan taurin 15,6 mg/ekor/hari selama 15 hari, K6 = benzo(α)piren 10 hari kemudian kombinasi ekstrak makroalga merah 8mg/ekor/hari dan taurin 15,6 mg/ekor/hari selama 15 hari. Data dalam penelitian ini dianalisis dengan metode statistik ANOVA pada taraf nyata 5%. Hasil penelitian menunjukkan pemberian kombinasi ekstrak makroalga cokelat, makroalga merah dengan dosis 8 mg/ekor/hari dan taurin dosis 15,6 mg/ekor/hari dapat memperbaiki secara nyata kerusakan histopatologi hepar dan ginjal mencit (Mus musculus) yang diinduksi benzo(α)piren. Kombinasi Ekstrak makroalga merah Gracillaria sp. dan taurin lebih efektif memperbaiki kerusakan hisptopatologi hepar dan ginjal mencit jantan yang telah diinduksi benzo(α)piren. Kata kunci: mencit jantan, makroalga, taurin, benzo(α)piren, histopatologi, hepar, ginjal abstract Cancer is a disease marked by the existence of abnormal growth of cell continuously and uncontroll in an organism body. Benzo(a)pyrene is one of the substances that can cause a cancer. The methanolicextract of Sargassum sp. andGracillaria sp. has anticancer and antioxidant activity. Other compounds with antioxidantactivity is taurine. The purpose of this research is to examine the effect from methanolicextract of Sargassum sp. andGracillaria sp.and also taurine on hepar and kidneyhistopatology of male mice(Mus musculus) induced by benzo(a)pyrene. This research used Completely Randomized Design.30 male mice were divided into 6 groups of treatments, those were: K1 = (K-), K2= induced by benzo(a)pyrenefor 10 days, K3= after induced by benzo(a)pyrene, were given the Sargassum sp. orally with a dose 8mg/mice during 15 days, K4=after induced by benzo(a)pyrene, were given the combination of Sargassum sp. (8mg/mice) and taurine(15,6mg/mice) orally during 15 days, K5= after induced by benzo(a)pyrene, were given the Gracillaria sp.orally with a dose 8mg/mice during 15 days, and K6=after induced by benzo(a)pyrene, were given the combination of Gracillaria sp.(8mg/mice) and taurine (15,6mg/mice)orally during 15 days.Data were analyzed using ANOVA (α = 5%). The result shows that the combination ofSargassum sp. andGracillaria sp.and taurinecan protect the damage of hepar and kidney histopatology of male mice(Mus musculus)induced by benzo(a)pyrene. Combination of extract Gracillaria sp. and taurine is themost effective to protect the damagehepar and kidney histopatology of male mice(Mus musculus) induced by benzo(a)pyrene. Keywords: male mice,Sargassum sp., Gracillaria sp., taurine, benzo(a)pyrene, hepar, kidney
| Jenis Karya Akhir: | Tesis (Masters) |
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| Subyek: | > QH Natural history > QH301 Biology |
| Program Studi: | FAKULTAS MIPA > Prodi Magister Ilmu Biologi |
| Pengguna Deposit: | 89740872 . Digilib |
| Date Deposited: | 25 Jan 2018 08:55 |
| Terakhir diubah: | 25 Jan 2018 08:55 |
| URI: | http://digilib.unila.ac.id/id/eprint/29926 |
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