PENGARUH PEMBERIAN MINUMAN RINGAN BERKARBONASI TERHADAP PERUBAHAN HISTOPATOLOGI LAMBUNG TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR Sprague dawley

WULAN ALAWIYAH JAHRA, 1511011072 (2019) PENGARUH PEMBERIAN MINUMAN RINGAN BERKARBONASI TERHADAP PERUBAHAN HISTOPATOLOGI LAMBUNG TIKUS PUTIH (Rattus norvegicus) JANTAN GALUR Sprague dawley. FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.

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Abstrak (Berisi Bastraknya saja, Judul dan Nama Tidak Boleh di Masukan)

Background: Carbonated soft drink is classified as a non-alcoholic type of beverages which gone through carbonation prosses with additions of caffein and phosporic acid. Increasing in the consumption of carbonated soft drink already happening for the last two decades. Based on 88 meta-analytical studies, it shows that consumption of carbonated soft drink may lead into several health issues, for examples an effect on gastrointestinal. Objective: The aim of this research is to observ any changes that might happened in gastric histopathological of white male rats (Rattus norvegicus) with Sprague- dawley strain because of the consumption of carbonated soft drink. Method: Quasi experimental research was done with randomized controlled method using post test only control group design. 24 white male rats (Rattus norvegicus) with Sprague-dawley strain was divided into 4 groups, consist of control group (K) which was given aquadest, treatment 1 group (P1) which was given carbonated soft drink with 3 ml/200 g/day, treatment 2 group (P2) with 6 ml/200 g/day, treatment 3 group (P3) with 12 ml/200 g/day. Overall research was observed for 30 days. Result: Average score of damage in gastric mucosa obtained using One Way ANOVA test with p=0.00 was 0.17 for control group, 0.7 for P1 group, 1.07 for P2 group, and 1.53 for P3 group. The test was followed by post hoc LSD test which resulted signifficant difference for all type of groups (p<0.05). Conclusion: There is a significant difference of carbonated soft drink consumption into white male rats (Rattus norvegicus) of Sprague-dawley strain gastric histopathological changes. Keywords: Carbonated soft drink, gastric histopathological, effect on gastrointestinal, white rats. Latar Belakang: Minuman ringan berkarbonasi adalah minuman non-alkohol yang mengalami proses karbonasi dengan tambahan zat seperti kafein dan asam fosfat. Pada dua dekade terakhir telah terjadi peningkatan konsumsi minuman berkarbonasi di dunia. Delapan puluh delapan studi meta-analisis menunjukan bahwa konsumsi minuman ringan berkarbonasi dapat menimbulkan masalah kesehatan seperti efek gastrointestinal. Tujuan: Penelitian ini bertujuan untuk mengetahui apakah minuman ringan berkarbonasi dapat mempengaruhi perubahan histopatologi lambung tikus putih (Rattus norvegicus) jantan galur Sprague dawley. Metode: Jenis penelitian kuasi eksperimental metode rancangan acak terkontrol menggunakan post test only control group designs. Sampel terdiri dari 24 ekor tikus putih jantan galur Sprague dawley, dibagi menjadi 4 kelompok: kelompok kontrol (K) hanya diberi aquades, perlakuan 1 (P1) diberi minuman ringan berkarbonasi dengan dosis 3 ml/200 gr/hari, perlakuan 2 (P2) 6 ml/200 gr/hari, dan perlakuan 3 (P3) dengan dosis 12 ml/200 gr/hari diberikan selama 30 hari. Hasil: Rerata skor kerusakan mukosa lambung pada kelompok K:0,17, P1:0,7, P2:1,07, dan P3:1,53. Data yang diperoleh diuji menggunakan One Way ANOVA didapatkan penelitian bermakna p=0,00, dilanjutkan dengan post hoc LSD didapatkan perbedaan bermakna pada semua kelompok (p<0,05). Simpulan: Terdapat pengaruh pemberian minuman ringan berkarbonasi terhadap perubahan histopatologi lambung tikus putih (Rattus norvegicus) jantan galur Sprague dawley. Kata Kunci: Minuman ringan berkarbonasi, histopatologi lambung, efek gastro intestinal, tikus putih.

Jenis Karya Akhir:	Skripsi
Subyek:	600 Teknologi (ilmu terapan) > 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan
Program Studi:	Fakultas Kedokteran > Prodi Pendidikan Dokter
Pengguna Deposit:	UPT . Teti Novianti
Date Deposited:	25 Mar 2022 07:41
Terakhir diubah:	25 Mar 2022 07:56
URI:	http://digilib.unila.ac.id/id/eprint/55911

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