PENGARUH PEMBERIAN EKSTRAK BIJI KOPI ROBUSTA (Coffeacanephora) LAMPUNG TERHADAP MEMORI SPASIAL TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR Sprague dawley YANG DIINDUKSIMONOSODIUM GLUTAMAT

Anis Syafa'atul Husna, 1518011063 (2019) PENGARUH PEMBERIAN EKSTRAK BIJI KOPI ROBUSTA (Coffeacanephora) LAMPUNG TERHADAP MEMORI SPASIAL TIKUS PUTIH JANTAN (Rattus norvegicus) GALUR Sprague dawley YANG DIINDUKSIMONOSODIUM GLUTAMAT. Fakultas Kedokteran , UNIVERSITAS LAMPUNG.

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Abstrak (Berisi Bastraknya saja, Judul dan Nama Tidak Boleh di Masukan)

Latar Belakang: Monosodium glutamat (MSG) sebagaipenyedap rasaapabiladiberikansecaraberlebihanakanmengaktivasireseptorglutamatberlebihsehingga dapatmenyebabkankerusakanotak.Kopi mengandungasamklorogenatyang bersifatneuroprotektif.Tujuanpenelitianiniuntukmengetahui pengaruhpemberianekstrak kopi robusta (Coffeacanephora) Lampung terhadapmemorispasialtikusputihjantan (Rattusnorvegicus) yang diinduksiMSG. Metode:Penelitianinidilakukandenganmetodeeksperimentaldenganrancanganacaklengkap . Jumlahsampelyang digunakansebanyak 25 ekordandibagi 5 kelompok, masingmasingterdiridari 5 ekortikus.PadapenelitianinitikusdiinduksiMSGperoraldengandosis 2 gr/kgBB/hariuntukkelompokkontrolpositifdansecaraberurutankelompokperlakuan 1, 2, dan3 disertaiinduksiekstrak kopirobusta Lampung dengandosis0,5 mg/mL/hari, 1 mg/mL/hari, dan 2 mg/mL/hari. SelanjutnyapenilaianmemorispasialdilakukandenganmetodeMorris Water Maze(MWM). Hasil:Hasilreratamemorispasialsecaraberurutankelompok K(-), K(+), P1, P2, P3 adalah22.75±4.50detik, 15.80± 9.91detik, 16.80± 5.71detik, 25.00± 15.13detik, 25.60± 10.47detik.Hasil analisis statistikOne Way Anova, nilai p=0,294 sehingga dapat dinyatakan bahwa tidak terdapat perbedaan rerata pada semuakelompok. Simpulan: Tidak terdapat pengaruh pemberian ekstrak kopi robusta (coffeacanephora) lampung terhadap memori spasial tikus putih jantan(rattus novergicus) galurspraguedawleyyang diinduksiMSG. Kata Kunci: kopi robusta, memori spasial, monosodium glutamat Background:Monosodium glutamate (MSG) as a flavor when given in excess will activate excess glutamate receptors so that it can cause brain damage. Coffee contains neuroprotectivechlorogenic acid. The purpose of this study was to determine the effect of Lampung Robusta coffee (Coffeacanephora) extract on the spatial memory of MSGinduced male white rats (Rattusnorvegicus). Method:This research was carried out using an experimental method with a completely randomized design. The number of samples used was 25 and divided into 5 groups, each consisting of 5 rats. In this study rats were induced by oral MSG at a dose of 2 gr / kgBW / day for the positive control group and sequentially treatment groups 1, 2, and 3 were accompanied by induction of Lampung robusta coffee extract at a dose of 0.5 mg / mL / day, 1 mg / mL / day, and 2 mg / mL / day. Furthermore, the assessment of spatial memory was carried out by the Morris Water Maze (MWM) method. Results:The average results of spatial memory sequentially groups K (-), K (+), P1, P2, P3 are 22.75 ± 4.50 second, 15.80 ± 9.91 second, 16.80 ± 5.71 second, 25.00 ± 15.13 second, 25.60 ± 10.47 secondThe results of One Way Anova analysis have a result of 0.294, p> 0.05. So that it can be stated that there is no difference in mean in all group. Conclusion:There is no effect on the administration of Robusta coffee extract (Coffeacanephora) Lampung to the spatial memory of male white rats (rattusnovergicus) spraguedawley lines induced by monosodium glutamate. Keywords: monosodium glutamate, robusta coffee, spatial memory

Jenis Karya Akhir:	Skripsi
Subyek:	600 Teknologi (ilmu terapan) > 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan
Program Studi:	Fakultas Kedokteran > Prodi Pendidikan Dokter
Pengguna Deposit:	UPT . Dito Nipati
Date Deposited:	14 Apr 2022 02:57
Terakhir diubah:	14 Apr 2022 02:57
URI:	http://digilib.unila.ac.id/id/eprint/58360

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