Anggia Shinta Wijaya Kusuma, 1118011007 (2015) PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.) TERHADAP KADAR MALONDIALDEHID (MDA) JARINGAN PAYUDARA TIKUS PUTIH BETINA YANG DIINDUKSI 7,12 DIMETILBENZ(α)ANTRASEN (DMBA). Fakultas Kedokteran, Universitas Lampung.
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Abstrak (Berisi Bastraknya saja, Judul dan Nama Tidak Boleh di Masukan)
Abstrac Breast cancer can occur due to the accumulation of DNA damage by various mechanisms, one of which is a result of oxidative stress. The use of natural materials is necessary given the many side effects of cancer therapy. Soursop leaves Annona muricata L. be an alternative because it is a leaves that has potential as an antioxidant. The aimed of study to determine the antioxidant effect of ethanol extract soursop leaves Annona muricata L. were evaluated from the levels of malondialdehyde (MDA) breast tissue of female mice. This research is an experimental design with 4 treatment groups. Group K1, negative control; group K2, positive control was induced DMBA 20 mg/kgBW 2 times a week; P20 given DMBA 20 mg/kgBW 2 times a week + soursop leaf extract 20 mg/kgBW; and P40 given DMBA 20 mg/kgBW 2 times a week + soursop leaf extract 40 mg/kgBW. Measurement of MDA conducted using methods Wills. The test results of one way ANOVA test was obtain p<0.005, showed that the ethanol extract of soursop leaves with a dose of 40 mg/kgBB has effect on MDA decreased levels of breast tissue female white rats that induced by DMBA. KeywordsKeywords KeywordsKeywords Keywords: Ethanol Extract Soursop leaves, MalondialdehydeEthanol Extract Soursop leaves, MalondialdehydeEthanol Extract Soursop leaves, Malondialdehyde Ethanol Extract Soursop leaves, M Malondialdehyde Ethanol Extract Soursop leaves, Malondialdehyde , OxidativeOxidative Oxidative OxidativeOxidativeOxidativeOxidative Abstrak Kanker payudara dapat terjadi karena akumulasi kerusakan DNA oleh berbagai mekanisme akibat stres oksidatif. Penggunaan bahan alami diperlukan mengingat banyaknya efek samping yang ditimbulkan dari terapi kanker. Daun sirsak (Annona muricata L.) dapat dijadikan alternatif pengobatan karena merupakan tanaman yang berpotensi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etanol daun sirsak yang ditinjau dari kadar malondialdehid (MDA) jaringan payudara tikus betina. Penelitian ini adalah penelitian eksperimental dengan 4 kelompok perlakuan. Kelompok K1, kontrol negatif,; kelompok K2, kontrol positif, diinduksi DMBA 20 mg/kgBB 2 kali seminggu; kelompok P20 diinduksi DMBA 20 mg/kgBB 2 kali seminggu + ekstrak daun sirsak 20 mg/kgBB/hari; dan kelompok P40 diinduksi DMBA 20 mg/kgBB 2 kali seminggu + ekstrak daun sirsak 40 mg/kgBB/hari. Pengukuran kadar MDA dilakukan menggunakan metode Wills. Pada uji one way ANOVA diperoleh nilai p<0,005, menunjukkan bahwa ekstrak etanol daun sirsak dengan dosis 40 mg/kgBB/hari berpengaruh terhadap penurunan kadar MDA jaringan payudara tikus putih betina yang diinduksi DMBA. Kata kunci: Ekstrak Etanol Daun sirsak, Malondialdehid (MDA), Stres Oksidatif
| Jenis Karya Akhir: | Skripsi |
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| Subyek: | |
| Program Studi: | Fakultas Kedokteran > Prodi Pendidikan Dokter |
| Pengguna Deposit: | 6858468 . Digilib |
| Date Deposited: | 17 Feb 2015 07:49 |
| Terakhir diubah: | 17 Feb 2015 07:49 |
| URI: | http://digilib.unila.ac.id/id/eprint/7147 |
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