Mariana , Lupita Sigalingging (2025) SINTESIS, KARAKTERISASI, DAN UJI ANTIPROLIFERASI SENYAWA DIBUTILTIMAH(IV) DI-(3-NITROBENZOAT) DAN DIBUTILTIMAH(IV) DIBENZOAT TERHADAP SEL KANKER PAYUDARA MICHIGAN CANCER FOUNDATION-7 (MCF-7). FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM , UNIVERSITAS LAMPUNG .
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Abstract
Penelitian ini bertujuan untuk mendapatkan senyawa-senyawa turunan organotimah(IV) yaitu senyawa dibutiltimah(IV) di-(3-nitrobenzoat) dan dibutiltimah(IV) dibenzoat, mengetahui karakteristik dari senyawa tersebut dengan menggunakan spektrofotometer UV-Visible, FTIR, 1H dan 13C-NMR, serta microelemental analyzer dan mengetahui aktivitas antiproliferasi terhadap sel kanker payudara MCF-7 dan aktivitasnya dibandingkan dengan sel normal. Senyawa dibutiltimah(IV) di-(3-nitrobenzoat) dan dibutiltimah(IV) dibenzoat berhasil disintesis melalui reaksi antara dibutiltimah(IV) oksida dengan ligan asam 3-nitrobenzoat dan asam benzoat. Produk hasil sintesis berupa serbuk putih dengan massa berturut-turut sebesar 1,9643 dan 1,8888 g, serta presentase rendemen sebesar 82,63% dan 94,46%. Senyawa hasil sintesis dikarakterisasi dengan menggunakan spektrofotometer UV-Visible, FTIR, 1H dan 13C-NMR, serta microelemental analyzer untuk mengetahui kemurnian senyawa. Aktivitas antiproliferasi senyawa sintesis telah diuji terhadap galur sel kanker payudara MCF-7 dan aktivitasnya dibandingkan dengan sel normal. Hasil uji antiproliferatif menunjukan bahwa senyawa dibutiltimah(IV) di-(3- nitrobenzoat) dan dibutiltimah(IV) dibenzoat memiliki aktivitas antiproliferatif cukup aktif dengan nilai IC50 sebesar 1,03 dan 4,65 μg/mL serta menunjukan indeks selektivitas terhadap sel vero berturut-turut sebesar 35,39 dan 12,06. Kata kunci: uji antiproliferasi, IC50, sel MCF-7, dibutiltimah(IV) di-3- nitrobenzoat, dibutiltimah(IV) dibenzoat This study aims to obtain organotin(IV) derivative compounds, namely dibutyltin(IV) di-(3-nitrobenzoate) and dibutyltin(IV) dibenzoate, to determine the characteristics of these compounds using UV-Visible, FTIR, 1H and 13C-NMR spectrophotometers, and microelemental analyzers and to determine the antiproliferative activity against MCF-7 breast cancer cells and its activity compared to normal cells. Dibutyltin(IV) di-(3-nitrobenzoate) and dibutyltin(IV) dibenzoate compounds were successfully synthesized through the reaction between dibutyltin(IV) oxide with 3-nitrobenzoic acid and benzoic acid ligands. The synthesis products were in the form of white powder with masses of 1.9643 and 1.8888 grams respectively, and yield percentages of 82.63% and 94.46%. The synthesized compounds were characterized using UV-Visible spectrophotometer, FTIR, 1H and 13C-NMR, and microelemental analyzer to determine the purity of the compounds. The antiproliferative activity of the synthesized compounds was tested against the MCF-7 breast cancer cell line and its activity was compared with normal cells. The results of the antiproliferative test showed that the compounds dibutyltin(IV) di-(3-nitrobenzoate) and dibutyltin(IV) dibenzoate had quite active antiproliferative activity with IC50 values of 1.03 and 4.65 μg/mL and showed selectivity indices against vero cells of 35.39 and 12.06, respectively. Keywords : antiproliferation assay, IC50, MCF-7 cells, dibutyltin(IV) di-3- nitrobenzoate, dibutyltin(IV) dibenzoate
| Item Type: | Other |
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| Subjects: | ?? 540 ?? |
| Divisions: | Fakultas MIPA > Prodi Kimia |
| Depositing User: | UPT . Siswanti |
| Date Deposited: | 24 Oct 2025 04:15 |
| Last Modified: | 24 Oct 2025 04:15 |
| URI: | http://digilib.unila.ac.id/id/eprint/91911 |
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