UJI EFEK ANTIBAKTERI EMULGEL EKSTRAK ETANOL KULIT BATANG BAKAU MINYAK (Rhizophora apiculata) TERHADAP BAKTERI Cutibacterium acnes, Staphylococcus aureus, DAN Staphylococcus epidermidis

LATANSA, AMANI RAYA (2025) UJI EFEK ANTIBAKTERI EMULGEL EKSTRAK ETANOL KULIT BATANG BAKAU MINYAK (Rhizophora apiculata) TERHADAP BAKTERI Cutibacterium acnes, Staphylococcus aureus, DAN Staphylococcus epidermidis. FAKULTAS KEDOKTERAN, UNIVERSITAS LAMPUNG.

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Abstrak (Berisi Bastraknya saja, Judul dan Nama Tidak Boleh di Masukan)

Latar Belakang: Penyakit infeksi kulit banyak ditemukan di daerah tropis akibat pertumbuhan mikroba patogen seperti Cutibacterium acnes, Staphylococcus aureus, dan Staphylococcus epidermidis. Meningkatnya resistensi bakteri terhadap antibiotik mendorong pencarian alternatif dari bahan alam. Tanaman bakau minyak (Rhizophora apiculata) diketahui mengandung metabolit sekunder yang berpotensi sebagai antibakteri. Emulgel dipilih sebagai sediaan topikal karena mampu meningkatkan stabilitas, penetrasi, serta efektivitas pelepasan zat aktif dalam terapi infeksi kulit. Metode: Metode penelitian ini merupakan studi eksperimental laboratorik. Sampel kulit batang bakau minyak dimaserasi dengan etanol 96% kemudian diformulasikan dalam bentuk emulgel menjadi 6 formulasi, yaitu F1 (0,5%), F2 (1%), F3 (2%), F4 (3%), F5 (4%), dan F6 (5%). Dilakuka Uji aktivitas antibakteri dengan metode difusi sumuran dan dilakukan uji KHM dan KBM. Hasil: Emulgel ekstrak etanol kulit batang bakau minyak (Rhizophora apiculata) memiliki aktivitas antibakteri terhadap bakteri Staphylococcus aureus dan Cutibacterium acnes pada kelompok P1-P6 yang terkategori kuat, dengan KHM pada kelompok P5 (4%) dan belum terdapat KBM. Sedangkan, pada bakteri Staphylococcus epidermidis mulai pada kelompok P1-P2 yang terkategori lemah, P3-P5 terkategori sedang dan P6 terkategori kuat, dengan KHM pada kelompokm P6 (5%) dan belum terdapat KBM. Kesimpulan: Emulgel ekstrak etanol kulit batang bakau minyak (Rhizophora apiculata) terbukti memiliki aktivitas antibakteri dan nilai KHM, namun belum terbukti memiliki nilai KBM terhadap bakteri Cutibacterium acnes, Staphylococcus aureus, dan Staphylococcus epidermidis. Kata Kunci: Cutibacterium acnes, Emulgel, Rhizophora apiculata, Staphylococcus aureus, Staphylococcus epidermidis Background: Infections of the skin are commonly found in tropical regions due to the proliferation of pathogenic microbes such as Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. The increasing bacterial resistance to antibiotics necessitates the search for alternative antimicrobial agents derived from natural sources. The oil mangrove plant (Rhizophora apiculata) is known to contain secondary metabolites with potential antibacterial properties. Emulgel was chosen as the topical dosage form because it is capable of enhancing the stability, penetration, and effectiveness of the active substance release in treating skin infections. Methods: The research method employed was a laboratory experimental study. The oil mangrove stem bark sample was macerated using 96% ethanol and subsequently formulated into an emulgel, resulting in six formulations: F1 (0.5%), F2 (1%), F3 (2%), F4 (3%), F5 (4%), and F6 (5%). The antibacterial activity test was carried out using the agar well diffusion method, and the MIC and MBC tests were also performed. Result: The emulgel ethanol extract of bark of Rhizophora apiculata exhibited antibacterial activity against Staphylococcus aureus and Cutibacterium acnes in treatment groups P1–P6, all of which were categorized as strong, with the MIC observed in group P5 (4%) and no MBC observed. In contrast, the antibacterial activity against Staphylococcus epidermidis was categorized as weak in groups P1–P2, moderate in groups P3–P5, and strong in group P6, with the MIC observed in group P6 (5%) and no MBC observed. Conclusion: The emulgel ethanol extract of bark of Rhizophora apiculata has been proven to have antibacterial activity and an MIC, but has not been proven to have an MBC against Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis. Key Words: Cutibacterium acnes, Emulgel, Rhizophora apiculata, Staphylococcus aureus, Staphylococcus epidermidis

Jenis Karya Akhir:	Skripsi
Subyek:	600 Teknologi (ilmu terapan) > 610 Ilmu kedokteran, ilmu pengobatan dan ilmu kesehatan
Program Studi:	FAKULTAS KEDOKTERAN (FK) > Prodi S1-Pendidikan Dokter
Pengguna Deposit:	2507572976 Digilib
Date Deposited:	19 Jan 2026 03:10
Terakhir diubah:	19 Jan 2026 03:10
URI:	http://digilib.unila.ac.id/id/eprint/94779

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