?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Bioaktivitas+Tetrahidro+Isokopalana+Dari+Callyspongia+sp.+sebagai+Antibakteri+Resisten+Escherichia+coli&rft.creator=Viqqi+Kurnianda%2C+1327011020&rft.subject=QD+Chemistry&rft.description=Abstrak+Bahasa+Indonesia%0D%0A%0D%0ATelah+dilakukan+penelitian+bioaktivitas+dari+sponge+laut+Callyspongia+sp.+Metabolit+bioaktif+diterpen+diisolasi+berdasarkan+bioaktivitas+melalui+beberapa+tahapan+kromatografi.+Data+interprestasi++LCMS-ESI+senyawa+bioaktif+memiliki+412.576+m%2Fz+dengan+formula+molekul+C24H44O5.+Analisis+IR+menunjukkan+metabolit+bioaktif+memiliki+gugus+eter+C-O+pada+1261+cm-1+dan+gugus+hidroksi+O-H+pada+3419+cm-1.+Analisis+lebih+lanjut+dengan+1H+NMR+dan+13C+NMR+mengindikasikan+bahwa+senyawa+metabolit+aktif+merupakan+tetrahidro+isokopalana.+Uji+aktivitas+terhadap+antibakteri+resisten+Escherichia+coli+menunjukkan+aktivitas+pada+dosis+25+mg%2FmL+dengan+zona+hambat+28+mm+(dia)+sedangkan+chloramphenicol+menunjukkan+zona+hambat+yang+signifikan+dengan+zona+hambat+9+mm+(dia)+pada+konsentrasi+30+mg%2FmL.+Hasil+menunjukkan+bahwa+tetrahidro+isokopalana+memiliki+potensi+aktivitas+terhadap+Escherichia+coli+yang+resisten+terhadap+chloramphenicol.%0D%0A%0D%0AKata+kunci%3A+Bioaktivitas%3B+sponge+laut%3B+antibakteri+resisten%3B+Escherichia+coli.%0D%0A%0D%0AAbstrak+Bahasa+Inggris%0D%0A%0D%0ABioactivity+research+from+Indonesian%E2%80%99s+marine+sponge+Callyspongia+sp.+has+been+done.+Bioactive+metabolite+diterpene+was+isolated+based+on+bioassay+guided+fractionation+with+several+steps+chromatography.+The+interpretation+LCMS-ESI+data+showed+412.576+m%2Fz+with+molecular+formula+C24H44O5.+Interpretation+with+IR+data+showed+bioactive+metabolite+has+ether+C%E2%80%93O+functional+group+at+1261+cm-1+and+hydroxy+functional+group+O%E2%80%93H+at+3419+cm-1.+Interpretation+with+1H+NMR+and+13C+NMR++indicated+that+metabolite+active+compound+as+a+tetrahydro+isocopalane.+The+antibacterial+activity+of+isolate+compound+has+been+conducted+against+Escherichia+coli+resistant.+The+result+antibacterial+activity+showed+that+isolate+compound+activity+is+strong+at+doses+25+mg%2FmL+with+inhibition+zone+28+mm+(dia).+Furthermore%2C+diameter+ratio+of+inhibition+zone+against+chloramphenicol+at+30+mg%2FmL+(dia.+9+mm)+showed+the+significant+different.+The+result+showed+that+tetrahydro+isocopalane+has+a+potential+activity+against+Escherichia+coli+which+resistant+to+chloramphenicol.%0D%0A%0D%0AKeywords%3A+Bioactivity%3B+marine+sponge%3B+antibacterial+resistant%3B+Escherichia+coli.%0D%0A&rft.date=2015-05-20&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F1%2F1.%2520Cover.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F2%2F2.%2520ABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F3%2F3.%2520ABSTRACT.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F4%2F4.%2520Lembar%2520Pengesahan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F5%2F5.%2520Lembar%2520Mengesahkan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F6%2F6.%2520Lembar%2520Pernyataan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F7%2F7.%2520Riwayat%2520Hidup.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F8%2F8.%2520Sanwacana.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F9%2F9.%2520DAFTAR%2520ISI.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F10%2F10.%2520DAFTAR%2520GAMBAR.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F11%2F11.%2520DAFTAR%2520TABEL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F98%2F1.%2520BAB%2520I%2520Pendahuluan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F13%2F13.%2520BAB%2520II.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F14%2F14.%2520BAB%2520III%2520.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F15%2F15.BAB%2520IV.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F99%2F5.%2520BAB%2520V.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F17%2F17.%2520DAFTAR%2520PUSTAKA.pdf&rft.identifier=++Viqqi+Kurnianda%2C+1327011020++(2015)+Bioaktivitas+Tetrahidro+Isokopalana+Dari+Callyspongia+sp.+sebagai+Antibakteri+Resisten+Escherichia+coli.++UNSPECIFIED.++++(Submitted)++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F10036%2F