?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=AKTIVITAS+ANTIKANKER+SENYAWA+BRUSEIN-A+YANG%0D%0ADIKAPSULASI+LIPOSOM+TERHADAP+SEL+KANKER+PAYUDARA%0D%0A(T47D)+SECARA+IN-VITRO&rft.creator=0614051029%2C+Dian+Wulandari&rft.subject=+&rft.description=Abstrak%0D%0A%0D%0AKanker+payudara+merupakan+tumor+ganas+yang+tumbuh+di+dalam+jaringan%0D%0Apayudara.+Penderita+kanker+payudara+membutuhkan+perhatian+khusus+karena%0D%0Asebagian+besar+penderitanya+berakhir+dengan+kematian.+Pengobatan+kanker%0D%0Apayudara+dapat+dilakukan+dengan+terapi+radiasi%2C+pembedahan%2C+dan+kemoterapi.%0D%0ATerapi+tersebut+dapat+merusak+sel+sehat+di+sekitar+sel+kanker%2C+menyebar+ke+bagian%0D%0Alain%2C+dan+mengakibatkan+sel+kanker+bermutasi+hingga+sulit+untuk+dihancurkan.%0D%0ABrusein-A+%2Cerupakan+senyawa+quasinoid+yang+sudah+teruji+memiliki+aktivitas%0D%0Aantikanker.+Aktivitas+brusein-A+dapat+ditingkatkan%2C+dengan+menggunakan%0D%0Aliposom.+Liposom+merupakan+membran+dua+lapis+fosfolipid+yang+menyerupai%0D%0Amembran+sel.+Oleh+karena+itu%2C+pembuatan+obat+kanker+payudara+dengan+bahan%0D%0Aaktif+brusein-A+yang+dikapsulasi+liposom+merupakan+metode+baru+untuk%0D%0Ameningkatkan+stabilitas+dan+aktivitasnya+dalam+membunuh+sel+kanker+payudara.%0D%0APenelitian+ini+bertujuan+bertujuan+untuk+mengetahui+aktivitas+antikanker+senyawa%0D%0Abrusein-A+yang+dikapsulasi+liposom+terhadap+sel+kanker+payudara+(T47D)+secara%0D%0Ain+vitro.%0D%0APenelitian+ini+dilakukan+dalam+3+ulangan+dengan+perlakuan+konsentrasi+brusein-A%0D%0Ayang+dikapsulasi+liposom+yang+terdiri+dari+10+taraf+yaitu+0%2C04+ppm%2C+0%2C08+ppm%2C+0%2C16%0D%0Appm%2C+0%2C31+ppm%2C+0%2C+63+ppm%2C+1%2C25+ppm%2C+2%2C5+ppm%2C+5+ppm%2C+10+ppm%2C+dan+20+ppm.+Data%0D%0Adisajikan+dalam+bentuk+tabel+dan+grafik+serta+dianalisis+dengan+regresi+linier+untuk%0D%0Amendapatkan+IC50.%0D%0AHasil+penelitian+menunjukkan+bahwa+senyawa+brusein-A+yang+dikapsulasi%0D%0Aliposom+pada+konsentrasi+0%2C07+ppm+dapat+menghambat+50%25+proliferasi+sel+kanker%0D%0Apayudara+(IC50).+Nilai+IC50+sebesar+0%2C07+ppm+jauh+lebih+aktif+dari+pada+nilai+IC50%0D%0Astandar+obat+antikanker+antimycin+(1%2C03+ppm)+dan+cisplatin+(0%2C43+ppm).+Aktifitas%0D%0Aantikanker+senyawa+brusein-A+yang+telah+dikapsulasi+liposom+meningkat+65+kali%0D%0Alipat%2C+yaitu+dari+4%2C6+ppm+menjadi+0%2C07+ppm.%0D%0AKata+kunci+%3A+antikanker%2C+brusein-A%2C+liposom%2C+sel+kanker+T47D.%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A%0D%0A%0D%0AAbstract%0D%0A%0D%0ABreast+cancer+is+such+a+malignant+tumor+which+grows+in+the+breast+tissue.+The%0D%0Asufferers+of+this+cancer+need+more+special+attention+because+most+of+them+usually%0D%0Aresulted+in+the+death+Medical+treatment+for+the+patients+of+breast+cancer+can+be%0D%0Atreated+by+radition+therapy%2C+surgery%2C+and+chemotherapy.+However%2C+these+therapies%0D%0Acan+damage+the+healt+cells+around+the+cancer+cells%2C+spread+to+the+other+location%2C%0D%0Aand+mutation+the+cancer+cells+so+that+difficult+to+destroy.%0D%0ABrusein-A+is+quasinoid+compound+which+has+anti-cancer+actibity.+Activity+of%0D%0Abrusein-A+is+can+be+increased+by+usng+liposome.+Liposom+has+two-layer%0D%0Amembranes+of+phospholipids+which+similar+sith+cell+membranes.+Production+of%0D%0Abreast+cancer+madicines+using+active-material.+Brucein-A+which+encapsulated+with%0D%0Aliposome+to+againts+berast+cancer+cell+is+a+new+method+for+increasing+the+stabilities%0D%0Aand+activities+in+killing+breast+cancer+cell.+The+purpose+of+this+research+is+find+out%0D%0Athe+activiyies+of+anti-cancer+compound+brusein-A+which+encapsulated+with%0D%0Aliposome+to+againts+breast+cancer+sell+(T47D)+in-vitro.%0D%0AThis+research+has+been+done+in+three+repetition+by+treating+the+concentration+of%0D%0Abrucein-A+encapsulated+with+liposom+and+formed+in+10+degrees%2C+i.e.+0%2C04+ppm%2C%0D%0A0%2C08+ppm%2C+0%2C16+ppm%2C+0%2C31+ppm%2C+0%2C+63+ppm%2C+1%2C25+ppm%2C+2%2C5+ppm%2C+5+ppm%2C+10+ppm%2C%0D%0Aand+20+ppm.+The+data+are+shown+in+table+and+graphic+and+analyzed+linier+to+found%0D%0AIC50.%0D%0AThe+result+of+the+research+shows+that+the+brucein-A+encapsulated+with+liposome+at%0D%0Athe+concentration+of+0%2C07+ppm+can+inhibit+50%25+proliferation+of+breast+cancel+cellsa%0D%0A(IC50).+Percentage+IC50+of+0%2C07+ppm+is+more+active+tan+IC50+from+the+standard+anticancer+antimycin+(1%2C03+ppm)+and+cisplatin+(0%2C43+ppm).+The+activity+of+anti-cancer%0D%0Abrusein-A+after+capsulated+with+liposome+has+increased+65+times%2C+i.e.+from+4%2C6%0D%0Appm+become+0%2C07+ppm.%0D%0AKeywords+%3A+anti-cancer%2C+brusein-A%2C+liposome%2C+cancer+cell+T47D.&rft.date=2012-02-03&rft.type=Skripsi&rft.type=PeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F12462%2F1%2FABSTRACT%2520inggris.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F12462%2F2%2FABSTRAK%2520%2528indo%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F12462%2F3%2Fcover.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F12462%2F4%2FDAFTAR%2520GAMBAR.pdf&rft.format=text&rf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