?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+MADU+Bee+pollen+TERHADAP+GAMBARAN%0D%0AHISTOPATOLOGI+GASTER+TIKUS+PUTIH+JANTAN+GALUR+Sprague%0D%0Adawley+YANG+DIINDUKSI+IBUPROFEN&rft.creator=FERINA+NUR+HAQIQI+%2C+1218011053&rft.subject=RC+Internal+medicine&rft.subject=RM+Therapeutics.+Pharmacology&rft.subject=RV+Botanic%2C+Thomsonian%2C+and+eclectic+medicine&rft.description=Insidensi+iritasi+gaster+semakin+meningkat+secara+global%2C+penyebab+tersering+adalah%0D%0Apengguanan+OAINS.+Efek+samping+yang+terjadi+pada+saluran+gastrointestinal+yaitu%0D%0Airitasi+gaster.+Salah+satu+pengobatan+alternatif+iritasi+gaster+yang+dikenal%0D%0Amasyarakat+yaitu+dengan+mengonsumsi+madu%2C+salah+satunya+madu+Bee+pollen+yang%0D%0Amerupakan+kombinasi+antara+madu+hutan+dan+serbuk+sari+dari+bunga+pollen.+Dalam%0D%0Apenelitian+ini+terdapat+24+sampel+yang+menjadi+4+kelompok.+Kelompok+A+adalah%0D%0Akontrol+normal+(hanya+diberikan+aquades).+Kelompok+B+adalah+kontrol+negatif%0D%0A(hanya+diberikan+ibuprofen+dan+aquades).+Kelompok+C+diberikan+ibuprofen+dan%0D%0Amadu+Bee+pollen+setengah+dosis+anjuran+(0%2C77+mL%2FkgBB+tikus).+Kelompok+D%0D%0Adiberikan+ibuprofen+dan+madu+Bee+pollen+sesuai+dosis+anjuran+(1.54+mL%2FkgBB%0D%0Atikus).+Perlakuan+diberikan+selama+14+hari.+Tikus+diterminasi+dengan+anastesi%0D%0Aterlebih+dahulu+menggunakan+ketamine+xylazine+secara+IP%2C+kemudian+di+euthanasia%0D%0Adengan+metode+cervical+dislocation+kemudian+diambil+organ+gaster+dan+selanjutnya%0D%0Adibuat+preparat+dilakukan+pengecatan+dengan+Hematoksilin%E2%80%92Eosin+(HE).+Hasil%0D%0Agambaran+histopatologi+diklasifikasikan+dalam+sistem+skoring+yaitu+0+berarti+tidak%0D%0Aada+nekrosis+dan+tidak+ada+sel+radang%2C+1+berarti+terdapat+nekrosis+setempat+(fokal)%0D%0Adan+terdapat+sel+radang+ringan%2C+2+berarti+nekrosis+merata+(difusa)+dan+sel+radang%0D%0Amenyebar+(multifokal)+dan+3+berarti+perforasi.+Didapatkan+data+yang+tidak+normal%0D%0Adan+homogen.+Uji+non+parametrik+menggunakan+uji+Kruskal%E2%80%92Wallis+yang%0D%0Adilanjutkan+dengan+uji+post+hoc+Mann%E2%80%92Whitney.+Berdasarkan+uji+statistik+diperoleh%0D%0Ahasil+terdapat+perbedaan+bermakna+antara+kelompok+A%2C+B%2C+C+dan+D.+Madu+Bee%0D%0Apollen+memiliki+pengaruh+terhadap+histopatologi+gaster+tikus+putih+jantan+galur%0D%0ASprague+dawley+yang+diinduksi+ibuprofen.%0D%0AKata+kunci%3A+Madu%2C+Bee+pollen%2C+gaster%2C+ibuprofen%0D%0A%0D%0Aabstract%0D%0A%0D%0ATHE+EFFECT+OF+Bee+pollen+HONEY+ON+HISTOPATHOLOGY%0D%0AIMAGING+OF+Sprague+Dawley+STRAIN+WHITE+RAT%E2%80%99S+GASTER+THAT%0D%0AINDUCED+BY+IBUPROFEN%0D%0A%0D%0AIncidence+of+gastric+irritation+is+increasing+globally%2C+caused+of+them+is+use+of%0D%0ANSAIDs.+Side+effects+that+could+be+occur+in+gastrointestinal+tract+is+gastric+irritation.%0D%0AAlternative+treatment+for+gastric+irritation+that+quite+popular+is+by+consuming+honey%2C%0D%0Alike+Bee+pollen+honey+which+is+combination+of+forest+honey+and+pollen+from+flower%0D%0Apollen.+In+this+study+there+were+24+samples+that+divided+into+4+groups.+Group+A+is%0D%0Athe+normal+control+(distilled+water).+Group+B+is+negative+control+(ibuprofen+and%0D%0Adistilled+water).+Group+C+were+induced+by+ibuprofen+and+Bee+pollen+honey+half+of%0D%0Athe+recommended+dose+(0%2C77+mL%2Fkg%E2%80%99s+rat).+Group+D+were+given+ibuprofen+and+Bee%0D%0Apollen+honey+with+recommended+dosage+(1%2C54+mL%2Fkg%E2%80%99s+rat).+Treatment+was+given%0D%0Afor+14+days.+Termination+was+done+by+anesthesia+that+used+ketamine-xylazine%0D%0Aintaperitoneal%2C+then+euthanasia+by+cervical+dislocation+method%2C+after+that+gastric+was%0D%0Ataken+and+slide+was+made+with+hematoxylin-eosin+(HE).+The+results+of%0D%0Ahistopathology+imaging+classified+in+a+scoring+system+that+is+0+means+no+necrosis%0D%0Aand+no+inflammatory+cells%2C+1+means+there+is+focal+necrosis+and+there+are%0D%0Ainflammatory+cells+lighter%2C+2+means+difuse+necrosis+and+multifocal+inflammatory%0D%0Acells+and+3+means+perforation.+The+data+was+abnormal+and+homogeneous.+Nonparametric%0D%0Atest+was+using+Kruskal-Wallis+test+followed+by+post+hoc+test+of+Mann-%0D%0AWhitney.+Based+on+the+test+results+that+obtained%2C+there+is+significantly+difference%0D%0Abetween+groups+A%2C+B%2C+C+and+D.+Bee+pollen+honey+has+healing+effect+on%0D%0Ahistopathology+imaging+of+Sprague+dawley+strain+white+rat%E2%80%99s+gaster+that+induced+by%0D%0Aibuprofen.%0D%0AKeywords%3A+Honey%2C+Bee+pollen%2C+gaster%2C+ibuprofen&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2015-12-15&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F1%2FABSTRACT.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F2%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F3%2FCOVER%2520DALAM.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F4%2FCOVER%2520LUAR.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F5%2FDAFTAR%2520GAMBAR.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F6%2FDAFTAR%2520LAMPIRAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F7%2FDAFTAR%2520TABEL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F42%2FDAFTAR%2520ISI.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F8%2FPENGESAHAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F9%2FPERNYATAAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F10%2FPERSEMBAHAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F11%2FPERSETUJUAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F12%2FRIWAYAT%2520HIDUP.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F13%2FSANWACANA.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F14%2FBAB%2520I.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F17%2FBAB%2520II.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F16%2FBAB%2520III.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F15%2FBAB%2520IV.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F43%2FBAB%2520V.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F18%2FDAFTAR%2520PUSTAKA.pdf&rft.identifier=++FERINA+NUR+HAQIQI+%2C+1218011053++(2015)+PENGARUH+MADU+Bee+pollen+TERHADAP+GAMBARAN+HISTOPATOLOGI+GASTER+TIKUS+PUTIH+JANTAN+GALUR+Sprague+dawley+YANG+DIINDUKSI+IBUPROFEN.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F18066%2F