?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EFEK+EKSTRAK+KULIT+PISANG+KEPOK+(Musa+acuminata)+TERHADAP+GAMBARAN+HISTOPATOLOGI+ULKUS+GASTER+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+Sprague+dawley+YANG+DIINDUKSI+ASPIRIN&rft.creator=+DEBORAH+N+%2C+1218011032&rft.subject=+&rft.description=ABSTRAK%0D%0AUlkus+gaster+adalah+ulserasi+atau+robeknya+lapisan+mukosa+yang+disebabkan+oleh+rusaknya+ketahanan+mukosa+gaster.+Untuk+mengatasinya+dibutuhkan+senyawa+antioksidan+yang+salah+satunya+terkandung+dalam+ekstrak+kulit+pisang.+Penelitian+ini+bertujuan+untuk+mengetahui+apakah+ekstrak+etanol+kulit+pisang+kepok+(Musa+acuminata)+dapat+memperbaiki+gambaranhistopatologi+gaster+yang+telah+diinduksi+aspirin+pada+tikus+putih+(Rattus+norvegicus)+galur+Sprague+dawley.+Penelitian+ini+menggunakan+25+ekor+tikus+putih+galur+Sprague+dawley+yang+dibagi+ke+dalam+5+kelompok%2C+yaitu+kontrol+1+(K1)+tikus+yang+tidak+diberikan+perlakuan%2C+kontrol+2+(K2)+diberikan+aspirin+dosis+90+mg%2Fhari%2C+pada+perlakuan+1+(P1)%2C+perlakuan+2+(P2)+dan+perlakuan+3+(P3)+diberikan+ekstrak+etanol+kulit+pisang+kapok+dengan+dosis+bertingkat+100%2C+200%2C+400+mg%2FkgBB+dan+diberikan+aspirin+oral+dosis+90+mg+dalam+waktu+14+hari.Setelahperlakuan%2C+semua+hewan+percobaan+dilakukan+euthanasia+dengan+menggunakan+ketamin+secara+intrakutan.kemudian+diambil+organ+gaster+dan+selanjutnya+dibuat+preparat+dilakukan+pengecatan+dengan+Hematoksilin%E2%80%92Eosin(HE).+Gambaran+pada+mukosa+gaster+diklasifikasikan+menjadi+normal%2C+peradangan%2C+kerusakan+mukosa+superfisial%2Cdan+kerusakan+mukosa+dalam.+Data+yang+diperoleh+dianalisis+dengan+menggunakan+ujistatistik+Kruskal%E2%80%92Wallis+yang+dilanjutkan+dengan+Uji+Statistik+Mann%E2%80%92Whitney.Berdasarkan+uji+statistik+diperoleh+hasil+terdapat+perbedaanbermakna+antara+kelompok+K1+dengan+K2+(p%3D0%2C017)%2C+K1+dan+P1+(p%3D0.016)%2CK2+dan+P3+(p%3D0%2C049)%2CP1+dan+P3+(P%3D0%2C058).+Sedangkan+pada+K1+dan+P2+(p%3D0%2C212)%2C+K1+dan+P3+(0%2C339)%2C+K2+dan+P1+(p%3D0%2C650)%2C+K2+dan+P2+(p%3D0%2C100)%2C+P1+dan+P2+(0%2C142)+dan+P2+dan+P3+(p%3D0%2C650)+tidak+didapat+perbedaan+bermakna.Aspirin+dapat+memengaruhi+struktur+mukosa+gaster+tikus+putih+dan+ekstrak+etanol+kulit+pisang+kepok+dapat+memperbaiki+kerusakan+sel+tersebut+pada+dosis+200+mg%2FkgBB.%0D%0AKata+kunci+%3A+antioksidan%2C+gaster%2C+kulit%2C+mukosa%2C+pisang%2C+ulkus%0D%0AABSTRACT%0D%0AGastric+ulcer+is+an+ulceration+or+open+sore+of+mucose+layer+caused+by+damage+in+gastric+mucose+barrier.+Overcoming+upon+that%2C+antioxidant+compund+in+banana+peel+extract+is+necessary.+The+goal+of+study+is+to+observe+whether+kepok+banana+(Musa+acuminata)+peel+ethanol+extract+able+to+repair+gastric+histopathological+finding+induced+by+aspirin+in+Sprague+dawleystrain+white+rat+(Rattus+norvegicus).+Thie+experimentasl+study+uses+25+Sprague+dawleystrain+white+rats+(Rattus+norvegicus)+lotted+into+5+groups%2C+consist+of+Group+Control+1+(K1)+which+does+not+have+any+treatment+intevention%2C+Group+Control+2+(K2)+which+is+given+aspirin+with+90+mg%2Fday+dosage%2C+on+Group+Treatment+1+(P1)%2C+Treatment+2+(P2)+and+Treatment+3+(P3)+are+given+kepok+banana+(Musa+acuminata)+peel+ethanol+extract+with+gradual+dose+100%2C+200%2C+400+mg%2FkgBW+and+induced+by+oral+aspirin+with+90+mg+dosage+for+14+days.+After+interventions%2C+euthanasia+is+done+with+all+animal+samples+by+ketamine+injection+subcutaneously%2C+afterwards+stomach+organ+is+taken+and+convert+it+into+histopathological+smear+with+Hematoxilin-eosin+(HE)+staining.+Histopathological+findings+are+classified+into+normal%2C+inflammation%2C+superficial+mucose+damage+and+deep+mucose+damage.+Results+are+analyzed+with+statistic+Kruskal%E2%80%92Wallistest+then+continue+with+Mann%E2%80%92Whitneytest.+Based+on+statistic+results%2C+there+are+significant+differences+between+K1+and+K2%2C+K1+and+P1+(p%3D0.016)%2CK2+and+P3+(p%3D0%2C049)%2CP1+and+P3+(P%3D0%2C058).+Meanwhile+on+K1+and+P2+(p%3D0%2C212)%2C+K1+and+P3+(0%2C339)%2C+K2+and+P1+(p%3D0%2C650)%2C+K2+and+P2+(p%3D0%2C100)%2C+P1+and+P2+(0%2C142)%2C+P2+and+P3+(p%3D0%2C650)+there+is+no+significant+difference.+Aspirin+can+influence+white+rat+gastric+mucose+structure+and+kepok+banana+peel+ethanol+extract+can+repair+cell+damage+on+200+mg%2FkgWB+dosage.%0D%0AKeywords+%3A+antioxidant%2C+banana%2C+gastric%2C+mucosa%2C+peel%2C+ulcer%0D%0A&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2015-11-30&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20602%2F1%2FABSTRACT.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20602%2F2%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20602%2F3%2FCOVER%2520DALAM.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20602%2F4%2FCOVER%2520LUAR.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20602%2F5%2FDAFTAR%2520GAMBAR.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20602%2F6%2FDAFTAR%2520ISI.pdf&rft.format=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