?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PERBANDINGAN+EFEK+DOSIS+TOKSIK+AMOKSISILIN+GENERIK+BERLOGO+DENGAN+AMOKSISILIN+GENERIK+BERMEREK+TERHADAP+KADAR+MALONDIALDEHID+(MDA)+RENAL+TIKUS+(Rattus+novergicus)+GALUR+Sprague+Dawley&rft.creator=ADE+MARANTIKA+%2C+1218011002&rft.subject=RM+Therapeutics.+Pharmacology&rft.description=ABSTRAK%0D%0AInsidensi+gangguan+fungsi+ginjal+akibat+antibiotik+mencapai+36%25.+Amoksisilin+merupakan+antibiotik+yang+paling+sering+digunakan+masyarakat+Indonesia%2C+bahkan+tanpa+resep+dokter.Terdapat+dua+macam+produk+amoksisilin+yang+tersedia+di+masyarakat%2C+yakni+amoksisilin+generik+berlogo+dan+generik+bermerek.Amoksisilin+dapat+menyebabkan+stress+oksidatif+dalam+tubuh+dimana+keadaan+ini+dapat+diukur+dengan+kadar+malondialdehid+(MDA).+Tujuan+penelitian+ini+adalah+untuk+mengetahui+perbedaan+efek+dosis+toksik+amoksisilin+generik+berlogo+dengan+amoksisilin+generik+bermerek+terhadap+kadar+MDA+renal+dan+mengidentifikasi+amoksisilin+yang+lebih+menyebabkanpeningkatan+kadarMDA+renal.+Penelitian+ini+merupakan+penelitian+eksperimental+yang+terdiri+atas+36+hewan+coba+yang+dibagi+menjadi+9+kelompok+dengan+3+kelompok+kontroldan+6+kelompok+perlakuan.+Hasil+penelitian+menunjukan+rerata+kadar+MDArenal+kelompok%2C+yakni+kelompok+kontrol+(Kn%3D1%2C356+nmol%2Fmg%2C+KA%3D6%2C090+nmol%2Fmg+dan+KB%3D6%2C922+nmol%2Fmg)%2C+kelompok+generik+berlogo+(A1%3D3%2C513+nmol%2Fmg%2C+A2%3D5%2C372+nmol%2Fmg+dan+A3%3D10%2C246+nmol%2Fmg)%2C+dan+kelompok+generik+bermerek+(B1%3D4%2C279+nmol%2Fmg%2C+B2%3D6%2C520+nmol%2Fmg+dan+B3%3D11%2C655+nmol%2Fmg).+Hasil+uji+perbandingan+menunjukan+bahwa+terdapat+perbedaan+bermakna+secara+statistik+antara+amoksisilin+generik+berlogo+dan+amoksisilin+generik+bermerek+terhadap+kadar+MDA+renal+hewan+coba+pada+dosis+822%2C4+mg%2FkgBB+dan+amoksisilin+generik+bermerek+menyebabkan+peningkatan+kadar+MDA+renal+lebih+tinggi+daripada+amoksisilin+generik+berlogo.%0D%0AKata+kunci%3A+Amoksisilin%2C+obat+generik+berlogo%2C+obat+generik+bermerek%2C%0D%0Amalondialdehid%0D%0AABSTRACT%0D%0AThe+incidence+of+renal+dysfunction+due+to+antibiotic+reaches+36%25.+Amoxicillin+is+an+antibiotic+that+is+most+commonly+used+by+the+people+of+Indonesia%2C+even+without+a+prescription.+There+are+two+kinds+of+amoxicillin+products+available+in+the+community%2C+which+are+generic+amoxicillin+and+branded+amoxicillin.+Amoxicillin+can+cause+oxidative+stress+in+the+body+where+this+state+can+be+measured+by+the+levels+of+malondialdehyde+(MDA).+The+purpose+of+this+study+was+to+determine+differences+in+the+effects+of+the+toxic+dose+of+generic+amoxicillin+and+branded+amoxicillin+on+renal+MDA+levels+and+identify+which+amoxicillin+cause+higher+increase+of+renal+MDA+levels.+This+study+is+an+experimental+study+consisting+of+36+test+animals+which+were+divided+into+9+groups+with+3+control+groups+and+six+treatment+groups.+The+results+showed+average+group+levels+of+MDA+renal%2C+namely+the+control+groups+(Kn+%3D+1.356+nmol%2Fmg%2C+KA+%3D+6.090+nmol%2Fmg+and+KB+%3D+6.922+nmol%2Fmg)%2C+the+generic+groups+(A1+%3D+3.513+nmol%2Fmg%2C+A2+%3D+5.372+nmol%2Fmg+and+A3+%3D+10.246+nmol%2Fmg)%2C+and+the+branded+groups+(B1+%3D+4.279+nmol%2Fmg%2C+B2+%3D+6.520+nmol%2Fmg+and+B3+%3D+11.655+nmol%2Fmg).+Comparison+test+results+showed+that+there+was+a+statistically+significant+difference+between+generic+amoxicillin+and+branded+amoxicillin+on+renal+MDA+levels+of+experimental+animals+at+a+dose+of+822.4+mg%2Fkg+and+branded+amoxicillin+increase+renal+MDA+levels+higher+than+generic+amoxicillin.%0D%0AKeywords%3A+Amoxicillin%2C+generic+drug%2C+branded+drug%2C+malondialdehyde%0D%0A%0D%0A&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2016-01-22&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F1%2FABSTRACT.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F2%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F3%2FCOVER%2520DALAM.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F4%2FCOVER%2520LUAR.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F5%2FDAFTAR%2520GAMBAR.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F7%2FDAFTAR%2520LAMPIRAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F8%2FDAFTAR%2520TABEL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F9%2FLEMBAR%2520PENGESAHAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F10%2FLEMBAR%2520PERNYATAAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F11%2FPERSEMBAHAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F12%2FRIWAYAT%2520HIDUP.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F13%2FLEMBAR%2520PERSETUJUAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20607%2F14%2FSANWACANA.pdf&rf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