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primary topic: PERBANDINGAN ANTARA PEMBERIAN DOSIS TOKSIK AMOKSISILIN GENERIK DENGAN AMOKSISILIN GENERIK BERMEREK TERHADAP AKTIVITAS SPESIFIK KATALASE GINJAL TIKUS PUTIH (Rattus norvegicus) GALUR Sprague dawley

PERBANDINGAN ANTARA PEMBERIAN DOSIS TOKSIK AMOKSISILIN GENERIK DENGAN AMOKSISILIN GENERIK BERMEREK TERHADAP AKTIVITAS SPESIFIK KATALASE GINJAL TIKUS PUTIH (Rattus norvegicus) GALUR Sprague dawley
type: Article
abstract: ABSTRAK Amoksisilin pada dosis toksik akan menyebabkan kerusakan pada tubulus proksimal ginjal dan menyebabkan akumulasi ROS ( Hidrogen peroksida/H ) . Enzim katalase merupakan enzim hidroperoksidase yang dapat mengkatalisis substrat H 2 O . Pada studi bioekivalensi disebutkan bahwa antara amoksisilin generik dengan amoksisilin generik bermerek dapat bioekuivalen ataupun tidak. Penelitian ini bertujuan untuk mengetahui perbedaan aktivitas spesifik katalase ginjal antara pemberian dosis toksik amoksisilin generik dengan amoksisilin generik bermerek. Penelitian eksperimental ini menggunakan 27 tikus putih jantan yang dibagi dalam 9 kelompok dan diberi perlakuan 3 kali sehari selama 14 hari. Kelompok KN ( diberi aquades 1 mL/hari ) , KA ( diberi amoksisilin generik 10.71 mg/kgBB ) , KB ( diberi amoksisilin generik bermerek 10.71 mg/kgBB ) , A1 ( diberi amoksisilin generik 102,8 mg/kgBB ) , A2 ( diberi amoksisilin generik 205,6 mg/kgBB ) , A3 ( diberi amoksisilin generik 411,2 mg/kgBB ) , B1 ( diberi amoksisilin generik bermerek 102,8 mg/kgBB ) , B2 ( diberi amoksisilin generik bermerek 205,6 mg/kgBB ) dan B3 ( diberikan amoksisilin generik bermerek 411,2 mg/kgBB ) . Tikus diterminasi dan diambil ginjalnya lalu diukur aktivitas spesifik katalase. Hasil penelitian menunjukan rerata aktivitas spesifik katalase ginjal kelompok KN yaitu 0,0015 U/mg, KA yaitu 0,0038 U/mg, KB yaitu 0,0040 U/mg, A1 yaitu 0,0025 U/mg, A2 yaitu 0,0038 U/mg, A3 yaitu 0,0055 U/mg, B1 yaitu 0,0027 U/mg, B2 yaitu 0,0041 U/mg dan B3 yaitu 0,0058 U/mg. Secara statistika terdapat perbedaan bermakna pada uji one way ANOVA ( p<0,05) dan uji Post Hoc LSD ( p<0,05) . Berdasarkan hasil uji tersebut memperlihatkan bahwa terdapat perbedaan aktivitas spesifik katalase ginjal antara tikus yang diberi amoksisilin generik dengan amoksisilin generik bermerek. 2 Kata kunci: amoksisilin generik, H 2 O 2 , kalatase, ROS ABSTRACT Amoxicillin in toxic doses would cause damage to the proximal tubule of the kidneys and c…
date: 2016-01-18
status: published
author list: authors
type: EPrint
type: OtherEPrint
is part of: repository
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Fakultas Kedokteran
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1218011054 FETIARA NUR’ANNISA ERFA EDDY
type: Person
given name: 1218011054
family name: FETIARA NUR’ANNISA ERFA EDDY

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http://digilib.unila.ac.id/id/document/1546790
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http://digilib.unila.ac.id/id/document/1546791
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http://digilib.unila.ac.id/id/document/1546793
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http://digilib.unila.ac.id/id/document/1546798
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http://digilib.unila.ac.id/id/document/1546838
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http://digilib.unila.ac.id/id/document/1546839
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http://digilib.unila.ac.id/id/document/1546840
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http://digilib.unila.ac.id/id/document/1546841
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http://digilib.unila.ac.id/id/document/1546842
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http://digilib.unila.ac.id/id/document/1546843
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http://digilib.unila.ac.id/id/document/1546846
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http://digilib.unila.ac.id/id/document/1546848
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http://digilib.unila.ac.id/id/document/1564195
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