?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PERBANDINGAN+PEMBERIAN+DOSIS+TOKSIK+AMOKSISILIN+GENERIK+BERLOGO+DAN+AMOKSISILIN+GENERIK+BERMEREK+TERHADAP+KADAR+MALONDIALDEHID+(MDA)+HEPAR+Rattus+norvegicus+GALUR+Sprague-Dawley&rft.creator=Dyah+Kartika+Utami%2C+1218011041&rft.subject=RM+Therapeutics.+Pharmacology&rft.description=ABSTRAK.+%0D%0AAmoksisilin+memiliki+rantai+yang+bersifat+elektronegatif+serta+cincin+betalaktam+yang+dapat+menyerang+grup+thiol+sehingga+dapat+menyebabkan+terbentuknya+Reactive+Oxygen+Species+(ROS)+yang+memicu+proses+peroksidasi+lipid+dengan+hasil+akhir+Malondialdehid+(MDA).+Penelitian+ini+bertujuan+untuk+membandingkan+kadar+MDA+hepar+Rattus+norvegicus+pada+pemberian+dosis+toksik+antara+amoksisilin+generik+berlogo+dan+generik+bermerek.+%0D%0APenelitian+ini+menggunakan+28+ekor+tikus+putih+jantan+galur+Sprague+Dawley+yang+dibagi+menjadi+1+kelompok+kontrol+dan+6+kelompok+perlakuan.+Kelompok+kontrol+diberikan+akuades.+Kelompok+perlakuan+terdiri+dari+kelompok+generik+berlogo+(A)+dan+kelompok+generik+bermerek+(B)+dengan+tiga+tingkatan+dosis+amoksisilin%2C+yaitu+205%2C6+mg%2FkgBB%3B+411%2C2+mg%2FkgBB%3B+serta+822%2C4+mg%2FkgBB.+Perlakuan+diberikan+sehari+tiga+kali+1+cc+selama+14+hari.+Hewan+coba+diterminasi+dengan+euthanasia+dan+cervical+dislocation.+Hepar+tikus+dibuat+homogenat+kemudian+dilakukan+pengukuran+kadar+MDA+menggunakan+Metode+Wills.+Data+dianalisis+secara+statistik+menggunakan+Uji+One+Way+ANOVA+dan+Post-Hoc+LSD.+%0D%0AHasil+bermakna+didapatkan+pada+perbandingan+antara+A3+dengan+B3+(p%3D0%2C000).+Hasil+tidak+bermakna+didapatkan+antara+A1+dengan+B1+(p%3D0%2C700)+dan+A2+dengan+B2+(p%3D0%2C831).+Terdapat+perbedaan+kadar+MDA+hepar+Rattus+norvegicus+galur+Sprague+Dawley+antara+pemberian+dosis+toksik+amoksisilin+generik+berlogo+dan+amoksisilin+generik+bermerek.%0D%0AABSTRACT.%0D%0AAmoxicillin+has+electronegative+side+chain+and+betalactam+ring+that+attack+thiol+group+and+produce+Reactive+Oxygen+Species+(ROS)+that+induce+lipid+peroxidation+with+malondialdehyde+(MDA)+as+its+final+product.+The+purpose+of+this+study+is+to+compare+rat+liver%E2%80%99s+malondialdehyde+level+on+toxic+dose+administration+of+generic+and+branded+amoxicillin.+%0D%0AThis+study+uses+28+male+rats+divided+into+1+control+group+and+6+experimental+groups.+Control+group+is+induced+with+aquadest.+Experimental+groups+are+consist+of+generic+groups+(A)+and+branded+groups+(B)%2C+induced+with+three+different+dose+of+amoxicillin%2C+which+is+205%2C6+mg%2Fkg%3B+411%2C2+mg%2Fkg%3B+and+822%2C4+mg%2Fkg.+Drugs+are+given+1+cc+three+times+per+day+for+14+days.+Rats+are+terminated+using+euthanasia+procedure+and+cervical+dislocation.+Rat+livers+are+processed+into+homogenates+and+MDA+level+is+determined+using+Wills+method.+Data+are+analyzed+using+One+Way+ANOVA+Test+and+Post-Hoc+LSD.+%0D%0AResults+are+found+to+be+significant+in+comparison+between+A3+and+B3+(p%3D0%2C000).+Results+are+insignificant+in+comparison+between+A1+and+B1+(p%3D0%2C700)+and+A2+and+B2+(p%3D0%2C831).+There+is+a+difference+of+rat+liver%E2%80%99s+MDA+level+between+toxic+dose+administration+of+generic+amoxicillin+and+branded+amoxicillin.%0D%0A&rft.publisher=Fakultas+Kedokteran&rft.date=2016-01-27&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F2%2F2.%2520abstract.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F3%2F3.%2520abstrak.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F4%2F4.%2520cover%2520dalam.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F5%2F5.%2520persembahan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F6%2F6.%2520lembar%2520persetujuan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F7%2F7.%2520lembar%2520pengesahan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F8%2F8.%2520lembar%2520pernyataan.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F9%2F9.%2520riwayat%2520hidup.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F10%2F10.%2520sanwacana.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F11%2F11.%2520daftar%2520isi.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F12%2F12.%2520daftar%2520tabel.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F13%2F13.%2520daftar%2520gambar.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F14%2F14.%2520daftar%2520lampiran.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F15%2F15.%2520BAB%2520I.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F16%2F16.%2520BAB%2520II.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F20737%2F17%2F17.%2520BAB%2520III.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.i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