%0 Generic
%A  BOBI KURNIA HARTANTO , 1218011028
%C UNIVERSITAS LAMPUNG
%D 2016
%F eprints:21729
%I FAKULTAS KEDOKTERAN 
%T PENGARUH MADU BEE POLLEN TERHADAP GAMBARAN  HISTOPSTOLOGI HEPAR TIKUS PUTIH JANTAN RATTUS  NOVERGICCUS GALUR SPRAGUE DAWLEY YANG DIINDUKSI  IBUPROFEN
%U http://digilib.unila.ac.id/21729/
%X ABSTRAK  Tubuh kita memerlukan substansi penting yaitu antioksidan yang dapat  melindungi tubuh dari serangan radikal bebas. Antioksidan tersebut terdapat pada  madu Bee pollen yang mengandung fenol yang dapat mengobati hepar yang telah  terinduksi ibuprofen. Ibuprofen memiliki sifat racun bagi hepar sehingga butuh  suatu antioksidan untuk melindungi bahkan mengobati hepar yang telah diinduksi  ibuprofen sebagai hepatotoksik. Kerusakan hepar disini diukur dari jumlah sel  hepar yang mengalami bengkak keruh untuk melihat tingkat kerusakan dari hepar  terseut dan dosis yang efektif dalam mengobati hepar yang telah diinduksi  ibuprofen.  Dalam penelitian ini terdapat 24 sampel yang menjadi 4 kelompok. Kelompok A  adalah kontrol normal   Hasil penelitian ini menunjukkan terdapat pengaruh madu Bee pollen terhadap  gambaran histopatologi hepar tikus putih rattus novergiccus galur Sprague dawley  yang diinduksi ibuprofen..  Kata kunci: Bee pollen, fenol, ibuprofen, hepar  ABSTRACT     Our body need an important substace which is antioksidant that can protect it  from a free radicals. Antioxidant can be found in Bee pollen honey that contains  fenol that can heal hepar that inducted by ibuprofen. Ibuprofen has a poison to  hepar that needs antioxidant to protecct even heal hepar that has inducted by  ibuprofen as hepatotoxic. A hepar damage here is counted by the amount of hepar  cells that turbid- swollen to see the damage rate or hepar and the evective dose to  heal hepar thar has inducted by ibuprofen.    In this study there were 24 samples that divided into 4 groups. Group A is the  normal control (distilled ibuprofen). Group B is negative control (ibuprofen and  distilled Bee pollen honey half of the recommended dose (0,77 mL/kg’s rat).  Group C were induced by ibuprofen and Bee pollen honey with recommended  dose (1,54 mL/kg’s rat). Group D were given ibuprofen and Bee pollen honey  with the higher dose (2,08 mL/kg’s rat). Treatment was given for 14 days.  Termination was doneby anesthesia thatused ketamine-xylazineintaperitoneal,  then euthanasia by cervical dislocation method, after that hepar was taken and  slide was made with hematoxylin-eosin (HE).    The results show an effect of Bee pollen honey on histopathology imaging of  Sprague Dawley strain white rat’s hepar that induced by ibuprofen.      Keywords: Bee pollen, fenol, ibuprofen, hepar