%A 1218011028  BOBI KURNIA HARTANTO 
%T PENGARUH MADU BEE POLLEN TERHADAP GAMBARAN
HISTOPSTOLOGI HEPAR TIKUS PUTIH JANTAN RATTUS
NOVERGICCUS GALUR SPRAGUE DAWLEY YANG DIINDUKSI
IBUPROFEN
%X ABSTRAK
Tubuh kita memerlukan substansi penting yaitu antioksidan yang dapat
melindungi tubuh dari serangan radikal bebas. Antioksidan tersebut terdapat pada
madu Bee pollen yang mengandung fenol yang dapat mengobati hepar yang telah
terinduksi ibuprofen. Ibuprofen memiliki sifat racun bagi hepar sehingga butuh
suatu antioksidan untuk melindungi bahkan mengobati hepar yang telah diinduksi
ibuprofen sebagai hepatotoksik. Kerusakan hepar disini diukur dari jumlah sel
hepar yang mengalami bengkak keruh untuk melihat tingkat kerusakan dari hepar
terseut dan dosis yang efektif dalam mengobati hepar yang telah diinduksi
ibuprofen.
Dalam penelitian ini terdapat 24 sampel yang menjadi 4 kelompok. Kelompok A
adalah kontrol normal 
Hasil penelitian ini menunjukkan terdapat pengaruh madu Bee pollen terhadap
gambaran histopatologi hepar tikus putih rattus novergiccus galur Sprague dawley
yang diinduksi ibuprofen..
Kata kunci: Bee pollen, fenol, ibuprofen, hepar
ABSTRACT
 
Our body need an important substace which is antioksidant that can protect it
from a free radicals. Antioxidant can be found in Bee pollen honey that contains
fenol that can heal hepar that inducted by ibuprofen. Ibuprofen has a poison to
hepar that needs antioxidant to protecct even heal hepar that has inducted by
ibuprofen as hepatotoxic. A hepar damage here is counted by the amount of hepar
cells that turbid- swollen to see the damage rate or hepar and the evective dose to
heal hepar thar has inducted by ibuprofen.

In this study there were 24 samples that divided into 4 groups. Group A is the
normal control (distilled ibuprofen). Group B is negative control (ibuprofen and
distilled Bee pollen honey half of the recommended dose (0,77 mL/kg?s rat).
Group C were induced by ibuprofen and Bee pollen honey with recommended
dose (1,54 mL/kg?s rat). Group D were given ibuprofen and Bee pollen honey
with the higher dose (2,08 mL/kg?s rat). Treatment was given for 14 days.
Termination was doneby anesthesia thatused ketamine-xylazineintaperitoneal,
then euthanasia by cervical dislocation method, after that hepar was taken and
slide was made with hematoxylin-eosin (HE).

The results show an effect of Bee pollen honey on histopathology imaging of
Sprague Dawley strain white rat?s hepar that induced by ibuprofen.


Keywords: Bee pollen, fenol, ibuprofen, hepar 
 
%C UNIVERSITAS LAMPUNG
%D 2016
%I FAKULTAS KEDOKTERAN 
%L eprints21729