?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=HUBUNGAN+KADAR+FERITIN+SERUM+DENGAN+AKTIVITAS+ENZIM%0D%0AASPARTAT+AMINOTRANSFERASE+(AST)%2C+ALANIN%0D%0AAMINOTRANSFERASE+(ALT)+DAN+STATUS+GIZI+PADA+ANAK%0D%0ATALASEMIA+%CE%B2+MAYOR&rft.creator=ANWAR+NUARI%2C++1118011012&rft.subject=RA0421+Public+health.+Hygiene.+Preventive+Medicine&rft.description=ABSTRAK%0D%0ATalasemia+merupakan+kelainan+darah+herediter+yang+ditandai+dengan+defisiensi%0D%0Ajumlah+produksi+rantai+globin+yang+spesifik+dalam+hemoglobin.+Talasemia+terdiri%0D%0Adari+talasemia+%CE%B1+dan+%CE%B2%2C+dimana+talasemia+%CE%B1+terjadi+karena+akibat+kurangnya%0D%0A(defisiensi+parsial)+atau+tidak+diproduksi+sama+sekali+(defisiensi+total)+produksi%0D%0Arantai+globin+%CE%B1%2C+sedangkan+talasemia+%CE%B2+terjadi+akibat+berkurangnya+rantai+globin+%CE%B2%0D%0Aatau+tidak+diproduksi+sama+sekali+rantai+globin+%CE%B2.%0D%0ATujuan+penelitian+adalah+untuk+mengetahui+hubungan+kadar+feritin+serum+dengan%0D%0Aaktivitas+enzim+AST%2C+ALT+dan+status+gizi+pada+anak+Talasemia+%CE%B2+mayor+di+RSUD%0D%0ADr.+H.+Abdoel+Moeloek.+Metode+penelitian+ini+adalah+survey+analitik+dengan%0D%0Apendekatan+cross+sectional.+Penelitian+ini+dilakukan+di+RSUD+Dr.+H.+Abdoel%0D%0AMoeloek+pada+bulan+Agustus+-September+2015.+Populasi+yang+digunakan+dalam%0D%0Apenelitian+ini+adalah+penderita+Talasemia+%CE%B2+mayor+di+yayasan+RSUD+Dr.+H.%0D%0AAbdoel+Moeloek.+Sampel+penelitian+berjumlah+61+orang+dengan+teknik%0D%0Apengambilan+sampel+menggunakan+consecutive+sampling.+Adapun+analisis%0D%0Astatistik+yang+digunakan+pada+penelitian+ini+adalah+uji+fisher+exact.%0D%0AHasil+penelitian+ini+adalah+terdapat+hubungan+yang+signifikan+antara+kadar+feritin%0D%0Aserum+dengan+AST+(p+%3D+0.02)+antara+feritin+dengan+kadar+ALT+(p+%3D+0.01)%2C+dan%0D%0Astatus+gizi+(p+%3D+0.01).%0D%0AKesimpulan+penelitian+ini+adalah+didapatkan+hubungan+yang+signifikan+antara%0D%0Apeningkatan+kadar+feritin+serum+terhadap+gangguan+fungsi+hati+dan+gangguan%0D%0Apertumbuhan+atau+gangguan+status+gizi+pada+pasien+thalasemia+%CE%B2+mayor+di%0D%0ARSUAM+Bandar+Lampung.%0D%0AKata+kunci%3A+ALT%2C+AST%2C+Kadar+feritin%2C+Talasemia+%CE%B2+Mayor%0D%0AABSTRACT%0D%0AThalassemia+is+a+hereditary+blood+disorder+characterized+by+a+deficiency+of+the%0D%0Aamount+of+production+of+globin+chains+specific+in+hemoglobin.+Thalassemia+is%0D%0Acomposed+of+%CE%B1+and+%CE%B2+Thalassemia%2C+in+which+%CE%B1+-thalassemia+occurs+as+a+result+of%0D%0Athe+lack+of+(+partial+deficiency+)+or+not+produced+at+all+(+total+deficiency+)+%CE%B1+globin%0D%0Achain+production%2C+whereas+%CE%B2+thalassemia+occurs+due+to+reduced+%CE%B2+globin+chain+or%0D%0Anot+produced+at+all+%CE%B2+globin+chain.%0D%0AThe+study+objective+was+to+determine+the+relationship+of+serum+ferritin+levels+with%0D%0Athe+activity+of+enzymes+AST%2C+ALT+and+nutritional+status+of+children+%CE%B2+thalassemia%0D%0Amajor+in+the+Hospital+Dr.+H.+Abdoel+Moeloek.+This+research+method+was%0D%0Aexperimental+research+with+cross+sectional+study+design.+This+research+was%0D%0Aconducted+at+the+Hospital+Dr.+H.+Abdoel+Moeloek+in+August+-+September+2015.%0D%0AThe+population+used+in+this+study+are+patients+with+%CE%B2+thalassemia+major+in+the%0D%0Afoundation+Hospital+Dr.+H.+Abdoel+Moeloek.+These+samples+included+61+people%0D%0Awith+a+sampling+technique+using+consecutive+sampling.+The+statistical+analysis%0D%0Aused+in+this+study+was+the+fisher+exact+test.%0D%0AThe+results+of+this+study+was+a+significant+correlation+between+serum+ferritin+levels%0D%0Awith+AST+(p+%3D+0.02+)+between+ferritin+with+ALT+levels+(p+%3D+0.01)+%2C+and+nutritional%0D%0Astatus+(p+%3D+0.01).%0D%0AThe+conclusions+of+this+study+is+a+significant+relationship+between+elevated+levels%0D%0Aof+serum+ferritin+to+liver+dysfunction+and+growth+disorders+or+disorders+of%0D%0Anutritional+status+in+patients+with+%CE%B2+thalassemia+major+in+RSUAM+Bandar%0D%0ALampung.%0D%0AKeywords%3A+ALT%2C+AST%2C+Ferritin+Levels%2C+Thalassemia+%CE%B2+Major&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2016-03-18&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F21784%2F1%2FABSTRAK%2520%2528ABSTRACT%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F21784%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F21784%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++ANWAR+NUARI%2C+1118011012++(2016)+HUBUNGAN+KADAR+FERITIN+SERUM+DENGAN+AKTIVITAS+ENZIM+ASPARTAT+AMINOTRANSFERASE+(AST)%2C+ALANIN+AMINOTRANSFERASE+(ALT)+DAN+STATUS+GIZI+PADA+ANAK+TALASEMIA+%CE%B2+MAYOR.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F21784%2F