TY  - GEN
CY  - Fakultas Kedokteran
ID  - eprints2295
UR  - http://digilib.unila.ac.id/2295/
A1  - Ahmad Arbi Anindito ,  
Y1  - 2014/02/10/
N2  - Background: Coronary heart disease is the leading causes of death in the world. 
One of its predisposing factor is high levels of total cholesterol and triglycerides. 
Javanese long pepper has piperine that can lowering the levels of total cholesterol 
and triglycerides. The purpose of this research was to find out the effect of 
javanese long pepper extract to total cholesterol and trygliceride levels in rats 
administrated by high fat diet. 
 
Methods: 21 rats were randomly divided into 3 groups. Group A were given 
standard diet for 7 weeks. Group B were given 10 gram of high fat diet for 7 
weeks. Group C were given 10 gram of high fat diet for 4 weeks and given 160 
mg/Kg of javanese long pepper extract from 5th week until 7th week. Blood 
sample was taken from the heart in the end of the 7th week. 
 
Results: Based on the Post Hoc LSD test, there was siginficant difference to total 
cholesterol and triglyceride levels between group A and group B (p<0,05), group 
B and group C (p<0,05) and group A and group C (p<0,05). 
 
Conclusions: The results show that javanese long pepper extract has an effect to 
total cholesterol and triglyceride levels in rats administrated by high fat diet 
(p=0,000). 
 
Keywords: high fat diet, javanese long pepper, total cholesterol, triglycerides
PB  - Universitas Lampung
TI  - The Effect of 95% Ethanol Extract of Javanese Long Pepper (Piper 
retrofractum Vahl.) to Total Cholesterol and Triglyceride Levels in Male 
Sprague Dawley Rats (Rattus novergicus) Administrated by High Fat Diet 
AV  - restricted
ER  -