?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+MINYAK+JELANTAH+TERHADAP%0D%0AGAMBARAN+HISTOPATOLOGI+ARTERI+KORONARIA%0D%0ATIKUS+PUTIH+(Rattus+norvegicus)+JANTAN%0D%0AGALUR+Sprague+dawley&rft.creator=NIDYA+TIAZ+PUTRI+AZHARI%2C++1318011120&rft.subject=Q+Science+(General)&rft.description=Latar+Belakang%3A+Minyak+jelantah+adalah+minyak+goreng+bekas+atau+minyak+yang%0D%0Adipanaskan+berulang+kali.+Minyak+goreng+yang+dipanaskan+akan+mengalami+empat%0D%0Aproses%2C+yaitu+perubahan+warna%2C+reaksi+oksidasi%2C+polimerisasi+dan+hidrolisis.+Pada%0D%0Areaksi+oksidasi+minyak+akan+menghasilkan+produk+radikal+bebas%2C+sedangkan+proses%0D%0Ahidrolisis+akan+membentuk+asam+lemak+bebas.+Konsumsi+minyak+jelantah+dapat%0D%0Ameningkatkan+kadar+radikal+bebas+dan+asam+lemak+dalam+tubuh.+Paparan+radikal%0D%0Abebas+pada+pembuluh+darah+dapat+menyebabkan+disfungsi+endotel+pembuluh+darah%0D%0Adan+asam+lemak+bebas+yang+berlebihan+dalam+darah+akan+mudah+melekat+pada%0D%0Adinding+bagian+dalam+pembuluh+darah.%0D%0ATujuan%3A+Untuk+mengetahui+adanya+pengaruh+pemberian+minyak+jelantah+terhadap%0D%0Agambaran+histopatologi+arteri+koronaria+dinilai+dari+perubahan+diameter+lumen+arteri%0D%0Akoronaria+tikus+Sprague+dawley+jantan.%0D%0AMetode%3A+Pada+penelitian+ini%2C+25+tikus+Sprague+dawley+jantan+dibagi+dalam+5%0D%0Akelompok+secara+acak+dan+diberi+perlakuan+selama+4+minggu.+K+(Kontrol)%2C+P1+(diberi%0D%0Aminyak+jelantah+1+kali+penggorengan+1%2C5+ml)%2C+P2+(diberi+minyak+jelantah+4+kali%0D%0Apenggorengan+1%2C5+ml)%2C+P3+(diberi+minyak+jelantah+8+kali+penggorengan+1%2C5+ml)%2C+P4%0D%0A(diberi+minyak+jelantah+12+kali+penggorengan+1%2C5+ml).+Pada+akhir+penelitian+tikus%0D%0Adilakukan+terminasi+dan+diambil+jantungnya+untuk+pembuatan+preparat+histologi+arteri%0D%0Akoronaria+dengan+pewarnaan+Hematoksilin+Eosin.%0D%0AHasil%3A+Pada+penelitian+ini+menunjukan+perbedaan+bermakna+(p%3C0%2C05)+pada+semua%0D%0Akelompok%2C+antara+lain+kelompok+K-P1%2C+K-P2%2C+K-P3%2C+K-P4%2C+P1-P2%2C+P2-P3%2C+P3-P4.%0D%0ARerata+diameter+lumen+kelompok+K%3A+147%2C02%C2%B11%2C85+%CE%BCm%2C+P1%3A+134%2C17%C2%B10%2C85+%CE%BCm%2C+P2%3A%0D%0A126%2C16%C2%B12%2C01+%CE%BCm%2C+P3%3A+117%2C19%C2%B15%2C57+%CE%BCm%2C+P4%3A+98%2C29%C2%B17%2C58+%CE%BCm.%0D%0AKesimpulan%3A+Terdapat+pengaruh+pemberian+minyak+jelantah+terhadap+gambaran%0D%0Ahistopatologi+arteri+koronaria+dinilai+dari+perubahan+diameter+lumen+arteri+koronaria%0D%0Atikus+Sprague+dawley+jantan.%0D%0AKata+kunci%3A+Minyak+jelantah%2C+diameter+lumen+arteri+koronaria%2C+tikus+Sprague+dawley%0D%0Ajantan%0D%0A%0D%0AASBTRACT%0D%0A%0D%0ABackground%3A+Reused+cooking+oil+is+used+cooking+oil+or+oil+heated+repeatedly.%0D%0AHeated+cooking+oil+will+undergo+four+processes%2C+namely+discoloration%2C+oxidation%2C%0D%0Apolymerization+and+hydrolysis.+In+the+oxidation+reaction+of+oil+will+produce+free%0D%0Aradicals%2C+while+the+process+of+hydrolysis+would+form+free+fatty+acids.+Reused%0D%0Acooking+oil+consumption+could+increase+levels+of+free+radicals+and+fatty+acids+in%0D%0Athe+body.+Exposure+to+free+radicals+in+the+blood+vessels+can+cause+vascular%0D%0Aendothelial+dysfunction+and+excessive+free+fatty+acids+in+the+blood+would+be+easily%0D%0Aattached+to+the+inner+walls+of+blood+vessels.%0D%0AObjective%3A+This+study+aims+to+determine+the+effect+of+cooking+oil+to+the+coronary%0D%0Aartery+histopathology+through+evaluation+of+the+coronary+artery+lumen+diameter+of%0D%0ASprague+dawley+rats.%0D%0AMethod%3A+In+this+study%2C+25+Sprague+dawley+rats+were+divided+randomly+into+5%0D%0Agroups+and+treated+for+4+weeks.+K+(control)%2C+P1+(1.5+ml+of+1+time+used+cooking%0D%0Aoil)%2C+P2+(1.5+ml+of+4+times+used+cooking+oil)%2C+P3+(1.5+ml+of+8+times+used+cooking%0D%0Aoil)%2C+P4+(1.5+ml+of+12+times+used+cooking+oil).+At+the+end+of+the+study+the+rats%0D%0Aperformed+termination+and+the+heart+had+been+taken+for+making+coronary+artery%0D%0Ahistology+preparations+with+Hematoxillin+Eosin+straining.%0D%0AResults%3A+The+results+showed+significant+differences+(p%3C0.05)+in+all+groups%2C+such+as%0D%0AK-P1%2C+P2-K%2C+K-P3%2C+K-P4%2C+P1-P2%2C+P2-P3%2C+P3-P4.+Mean+of+lumen+diameter+of+group%0D%0AK%3A+147.02%C2%B11.85+%CE%BCm%2C+P1%3A+134.17%C2%B10.85+%CE%BCm%2C+P2%3A+126.16%C2%B12.01+%CE%BCm%2C+P3%3A+117.19%C2%B15.57%0D%0A%CE%BCm%2C+P4%3A+98.29%C2%B17.58+%CE%BCm.%0D%0AConclusion%3A+The+conclusion+of+this+study+that+there+is+an+effect+of+consuming%0D%0Areused+cooking+oil+toward+the+coronary+artery+histopathology+through+evaluation%0D%0Aof+the+coronary+artery+lumen+diameter+of+Sprague+Dawley+rats.%0D%0AKeywords%3A+Reused+cooking+oil%2C+coronary+artery+lumen+diameter%2C+Sprague+dawley%0D%0Arats&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2017-01-09&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25263%2F1%2FABSTRACT%2520%2528ABSTRAK%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25263%2F20%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25263%2F19%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++NIDYA+TIAZ+PUTRI+AZHARI%2C+1318011120++(2017)+PENGARUH+PEMBERIAN+MINYAK+JELANTAH+TERHADAP+GAMBARAN+HISTOPATOLOGI+ARTERI+KORONARIA+TIKUS+PUTIH+(Rattus+norvegicus)+JANTAN+GALUR+Sprague+dawley.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F25263%2F