?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+MINYAK+JELANTAH+PADA+GAMBARAN+HISTOPATOLOGI+MIOKARDIUM+TIKUS+PUTIH+(Rattus+norvegicus)+JANTAN+GALUR+Sprague+dawley&rft.creator=+TRI+NOVITA+SARI+%2C+1318011169&rft.subject=RS+Pharmacy+and+materia+medica&rft.description=Latar+belakang%3APenyakit+kardiovaskular+merupakan+penyakit+penyebab+kematian+nomor+satu+didunia.+Salah+satu+penyakit+kardiovaskular+yang+berbahaya+yaitu+miokarditis.+Miokarditis+tidak+hanya+disebabkan+oleh+organisme+tetapi+juga+dapat+disebabkan+oleh+faktor+non+organisme+seperti+terjadinya+kerusakan+pada+sel+akibat+radikal+bebas.+Radikal+bebas+dapat+ditemukan+pada+hasil+dari+pemakaian+minyak+berulang.+Pemakaian+minyak+berulang+dapat+merusak+struktur+kimia+pada+minyak+goreng+melalui+proses+hidrolisis%2C+oksidasi+dan+polimerisasi+yang+akan+menghasilkan+senyawa+toksis+yang+dapat+merusak+jaringan+tubuh+seperti+pada+miokardium.%0D%0ATujuan%3Auntuk+mengetahui+pengaruh+pemberian+minyak+jelantah+terhadap+perubahan+histopatologi+miokardium+dan+untuk+mengetahui+pengaruh+perbedaan+frekuensi+penggorengan+pada+perubahan+gambaran+histopatologi+miokardium+tikus+jantan+Sprague+dawley.%0D%0AMetode%3APenelitian+ini+menggunakan+25+ekor+tikus+putih+jantan+Sprague+dawley+dibagi+5+kelompok+secara+acak.+Kelompok+K+(Kontrol)+dan+kelompok+P1%2C+P2%2CP3%2C+dan+P4+yang+masing-masing+diberikan+minyak+1x%2C+4x%2C+8x%2C+dan+12x+penggorengan+dengan+dosis+1%2C5+mL%2Fhari.%0D%0AHasil%3A+Hasil+rerata+pada+kelompok+K%2C+P1%2C+P2%2C+P3%2C+dan+P4+adalah+0%2C14%3B+0%2C48%3B+0%2C96%3B+1%2C6%3B+1%2C84+dengan+hasil+analisis+Kruskall-Wallis+adalah+nilai+p+0%2C003+(p%3C0%2C05).+Hasil+uji+Mann-Whitney+adalah+kelompok+K-P1+0%2C513%3B+K-P2+0%2C015%3B+K-P3+0%2C011%3B+K-P4+0%2C007%3B+P1-P2+0%2C042%3B+P1-P3+0%2C020%3B+P1-P4+0%2C011%3B+P2-P3+0%2C221%3B+P2-P4+0%2C072%3B+P3-P4+0%2C513+(p%3C0%2C05).%0D%0AKesimpulan%3AHal+ini+menunjukkan+bahwa+adanya+pengaruh+pada+pemberian+minyak+jelantah+terhadap+perubahan+histopatologi+miokardium.+Dan+untuk+kelompok+K+dan+P1+belum+mengalami+kerusakan+miokardium+sedangkan+kelompok+P2%2C+P3+dan+P4+telah+mengalami+kerusakan+pada+miokardium.%0D%0AKata+kunci+%3A+minyak+jelantah%2C+miokardium%2C+histopatologi%0D%0A%0D%0AASBTRACT%0D%0A%0D%0ABackground%3ACardiovascular+disease+is+the+leading+cause+of+death+of+most+people+in+the+world.+One+of+the+dangerous+cardiovascular+disease+is+myocarditis.+Myocarditis+is+not+only+caused+by+organism+factor+but+also+non+organism+factor%2C+such+as+cell+injury+which+is+caused+by+free+radical.+Free+radical+can+be+resulted+from+reused+cooking+oil.+Reused+cooking+oil+will+change+the+chemical+structure+of+cooking+oil+through+hydrolysis%2C+oxidation%2C+and+polymerization.+These+processes+will+produce+toxic+components+and+destroy+tissues+in+the+body%2C+including+myocardium.+Objective%3Ato+know+the+effect+of+reused+cooking+oil+to+myocardium+histopathology+and+to+know+the+effect+of+frying+frequency+differences+to+myocardium+histopathology+male+rats+strain+Sprague+dawley.%0D%0AMethods%3AThis+experiment+uses+25+male+rats+Sprague+dawley+divided+into+5+goups+randomly.+K+Group+(Control)%2C+P1%2C+P2%2C+P3%2C+and+P4+groups+which+each+of+them+is+given+reused+cooking+oil+1x%2C+4x%2C8x%2C+and+12x+frying+with+1%2C5+mL%2Fday+doses.%0D%0AResults%3AThe+avarage+value+of+K%2CP1%2C+P2%2CP3%2C+P4+groupsare+0%2C14%3B+0%2C48%3B+0%2C96%3B+1%2C6%3B+1%2C84+with+of+Kruskall-Wallisdata+analysis+test+show+p-value+0%2C003+(p%3C0%2C05).+The+result+of+Mann-Whitney+test+are+K-P1+0%2C513%3B+K-P2+0%2C015%3B+K-P3+0%2C011%3B+K-P4+0%2C007%3B+P1-P2+0%2C042%3B+P1-P3+0%2C020%3B+P1-P4+0%2C011%3B+P2-P3+0%2C221%3B+P2-P4+0%2C072%3B+P3-P4+0%2C513+(p%3C0%2C05).%0D%0AConclusion%3AIt+can+be+concluded+that+there+is+an+effect+of+reused+cooking+oil+administration+to+myocardium+histopathology+changes.+And+This+result+indicates+that+K+and+P1+groups+haven%E2%80%99t+present+myocardial+injury+but+P2%2C+P3%2C+and+P4+groups+have+present+myocardial+injury.%0D%0AKeywords%3A+reused+cooking+oil%2C+myocardium%2C+histopathology&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2017-01-16&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25265%2F1%2FABSTRACT%2520%2528ABSTRAK%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25265%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25265%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=+++TRI+NOVITA+SARI+%2C+1318011169++(2017)+PENGARUH+PEMBERIAN+MINYAK+JELANTAH+PADA+GAMBARAN+HISTOPATOLOGI+MIOKARDIUM+TIKUS+PUTIH+(Rattus+norvegicus)+JANTAN+GALUR+Sprague+dawley.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F25265%2F