?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=%0D%0APENGARUH+PEMBERIAN+EKSTRAK+ETANOL+96%25+BIJI+JENGKOL+(Pithecollobium+lobatum)+TERHADAP+GAMBARAN+HISTOPATOLOGI+JARINGAN+GINJAL+SERTA+PENINGKATAN+KADAR+UREUM+KREATININ+TIKUS+PUTIH+(Rattus+norvegicus)%0D%0AJANTAN+GALUR+Sprague+dawley%0D%0A&rft.creator=FARIDAH+ALATAS%2C+1318011066&rft.subject=RS+Pharmacy+and+materia+medica&rft.description=Latar+Belakang%3A+Gagal+ginjal+akut+cukup+sering+terjadi+dan+dapat+disebabkan+oleh+keracunan+jengkol+atau+djengkolism.+Jengkol+memiliki+kandungan+asam+jengkolat+yang+dapat+mengkristal+dalam+suasana+asam+dan+sukar+larut+dalam+air+sehingga+bersifat+nefrotoksik.+Penelitian+ini+bertujuan+untuk+mengetahui+pengaruh+pemberian+ekstrak+etanol+96%25+biji+jengkol+(Pithecollobium+lobatum)+terhadap+gambaran+histopatologi+jaringan+ginjal%2C+peningkatan+kadar+ureum+dan+kreatinin%2C+serta+hubungan+antara+kerusakan+gambaran+histopatologi+jaringan+ginjal+dengan+peningkatan+kadar+ureum+dan+kreatinin.%0D%0AMetode%3A+Penelitian+ini+merupakan+penelitian+analitik+eksperimental+dengan+metode+Post+Test+Only+Control+Group+Design.+Menggunakan+20+ekor+tikus+putih+(Rattus+norvegicus)+jantan+galur+Sprague+Dawley+dengan+berat+badan+200%E2%88%92250+gram%2C+berumur+3%E2%88%924+bulan+yang+dibagi+menjadi+4+kelompok+untuk+digunakan+sebagai+penelitian.%0D%0AHasil%3A+Berdasarkan+hasil+uji+Kruskal-Wallis%2C+diperoleh+nilai+p%3C0%2C05+yang+menunjukkan+terdapat+perbedaan+kerusakan+jaringan+ginjal+terhadap+peningkatan+dosis+ekstrak+biji+engkol.+Hasil+uji+one+way+ANOVA+diperoleh+nilai+p%3C0%2C05+terhadap+peningkatan+kadar+ureum+dan+kreatinin+serta+didapatkannya+perbedaan+kerusakan+jaringan+ginjal+dengan+peningkatan+kadar+ureum+kreatinin.%0D%0ASimpulan%3A+Peningkatan+dosis+ekstrak+etanol+96%25+biji+jengkol+dapat+menyebabkan+kerusakan+jaringan+ginjal+serta+peningkatan+rerata+kadar+ureum+diatas+normal+dan+peningkatan+rerata+kadar+kreatinin+yang+masih+dalam+batas+normal+pada+seluruh+kelompok+perlakuan%0D%0A%0D%0AKata+Kunci%3A+Ginjal%2C+Jengkol%2C+Kreatinin%2C+Ureum+%0D%0A%0D%0A%0D%0A%0D%0AABSTRACT%0D%0A%0D%0ABackground%3A+Acute+renal+failure+is+quite+common+and+can+be+caused+by+jengkol+poisoning+or+djengkolism.+Jengkol+contains+jengkolat+acid+which+can+be+crystallized+in+the+acid+environment+and+soluble+in+water%2C+therefore+it+is+nephrotoxic.+This+study+is+to+determine+the+effect+of+giving+extract+djengkol+seed+(Pithecollobium+lobatum)+96%25+etanol+to+overview+the+histopatological+kidney+tissue%2C+ureum+and+creatinine+level+increases+and+the+relationship+between+the+histopatological+kidney+tissue+with+increased+levels+of+ureum+and+creatinine+of+white+rat+(Rattus+norvegicus)+of+Sprague+dawley+strain.%0D%0AMethod%3A+This+study+is+an+Experimental+Analytical+Methods+with+Post+Test+Only+Control+Group+Design.+Samples+were+20+male+white+rat+(Rattus+norvegicus)+from+Sprague+dawley+strain+with+200-250+grams+body+weight%2C+3-4+months+and+they+were+divided+into+4+groups.%0D%0AResult%3A+The+result+showed+that+Kruskal-Wallis+test%2C+the+value+of+p%3C0%2C05+which+indicated+there+are+differences+in+kidney+tissue+damage+against+increasing+extract+djengkol+seed+doses.+The++result+showed+that+one-way+ANOVA+test%2C+the+value+of+p%3C0%2C05+for+increased+levels+of+urea+and+creatinine+and+there+are+differences+between+kidney+tissue+damage+with+increased+of+ureum+and+creatinine+levels.%0D%0AConclusion%3A+Increased+of+extract+djengkol+seed+doses+can+cause+kidney+tissue+damage+and+increased+average+of+ureum+levels+above+normal+and+average+of+creatinine+levels+were+still+within+normal+limits+in+all+treatment+groups.%0D%0A%0D%0AKeywords%3A+Creatinine%2C+Djengkol%2C+Kidney%2C+Ureum%0D%0A&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2017-01-17&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25276%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25276%2F2%2FSKRIPSI%2520TANPA%2520PEMBAHASAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25276%2F3%2FSKRIPSI%2520FULL.pdf&rft.identifier=++FARIDAH+ALATAS%2C+1318011066++(2017)++PENGARUH+PEMBERIAN+EKSTRAK+ETANOL+96%25+BIJI+JENGKOL+(Pithecollobium+lobatum)+TERHADAP+GAMBARAN+HISTOPATOLOGI+JARINGAN+GINJAL+SERTA+PENINGKATAN+KADAR+UREUM+KREATININ+TIKUS+PUTIH+(Rattus+norvegicus)+JANTAN+GALUR+Sprague+dawley.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F25276%2F