?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PERBANDINGAN+EFEK+PEMBERIAN+ASAM+FOLAT+SELAMA%0D%0AKEHAMILAN+TERHADAP+KEJADIAN+NEURAL+TUBE+DEFECTS+(NTD)%0D%0APADA+FETUS+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+SPRAGUE%0D%0ADAWLEY&rft.creator=+ANALIA%2C++(1318011009)&rft.subject=RS+Pharmacy+and+materia+medica&rft.description=Latar+Belakang%3A+Neural+Tube+Defects+(NTD)+atau+cacat+tabung+saraf+merupakan%0D%0Amalformasi+pada+sistem+saraf+pusat+yang+diakibatkan+kegagalan+penutupan+tabung+saraf%0D%0Aselama+embriogenesis.+Suplementasi+asam+folat+diperlukan+untuk+mencegah+bayi+lahir%0D%0Adengan+NTD.+Penelitian+ini+bertujuan+untuk+mengetahui+efek+asam+folat+pada+berbagai%0D%0Aperiode+pemberian+terhadap+kejadian+NTD+pada+fetus+tikus+putih+(Rattus+norvegicus)%0D%0Agalur+Sprague+dawley.%0D%0AMetode%3A+Penelitian+ini+menggunakan+30+ekor+tikus+putih+betina+galur+Sprague+dawley%0D%0Adengan+berat+badan+200-250+gram+yang+dibagi+ke+dalam+lima+kelompok%2C+yaitu+kontrol%0D%0Anegatif+(KN)+yang+tidak+diberikan+asam+folat+selama+kehamilan%2C+kontrol+positif+(KP)+yang%0D%0Adiberikan+asam+folat+selama+kehamilan%2C+perlakuan+1+(P1)+yang+diberikan+asam+folat+pada%0D%0Atrimester+satu%2C+perlakuan+2+(P2)+yang+diberikan+asam+folat+pada+trimester+dua%2C+dan%0D%0Aperlakuan+3+(P3)+yang+diberikan+asam+folat+pada+trimester+tiga.%0D%0AHasil+Penelitian%3A+Pada+kelompok+KN+didapatkan+tiga+ekor+fetus+dengan+NTD%3B+pada+KP%0D%0Asemua+fetus+normal%3B+pada+P1+semua+fetus+normal%3B+pada+P2+semua+fetus+normal%3B+pada+P3%0D%0Asemua+fetus+normal.+Data+yang+diperoleh+dianalisis+dengan+menggunakan+uji+Kruskal-%0D%0AWallis+dan+didapatkan+nilai+signifikansi+p%3D0%2C080.%0D%0AKesimpulan%3A+Tidak+terdapat+perbedaan+efek+asam+folat+pada+berbagai+periode+pemberian%0D%0Aterhadap+kejadian+NTD+pada+fetus+tikus+putih+(Rattus+norvegicus)+galur+Sprague+dawley%0D%0AKata+kunci%3A+Asam+folat%2C+kehamilan%2C+neural+tube+defects%2C+tikus+putih%0D%0A%0D%0AABSTRACT%0D%0A%0D%0ABackground%3A+Neural+Tube+Defects+(NTD)+are+malformations+of+the+central+nervous%0D%0Asystem+which+are+caused+by+failure+of+neural+tube+closure+during+embryogenesis.+Folic%0D%0Aacid+supplementation+is+needed+to+prevent+babies+born+with+neural+tube+defects.+This%0D%0Astudy+aims+to+determine+the+effect+of+folic+acid+on+the+various+administration+periods%0D%0Aagainst+NTD+incidence+of+fetal+rats+(Rattus+norvegicus)+strains+Sprague+dawley.%0D%0AMethods%3A+This+study+used+30+white+female+rats+(Rattus+norvegicus)+strains+Sprague%0D%0Adawley+with+200-250+grams+body+weight+which+are+divided+into+five+groups%3A+negative%0D%0Acontrol+(NC)+were+not+given+folic+acid+during+pregnancy%2C+positive+control+(PC)+were%0D%0Agiven+folic+acid+during+pregnancy%2C+treatment+group+1+(P1)+were+given+folic+acid+in+first%0D%0Atrimester%2C+treatment+group+2+(P2)+were+given+folic+acid+in+second+trimester%2C+and+treatment%0D%0Agroup+3+(P3)+were+given+folic+acid+in+third+trimester.%0D%0AResults%3A+In+NC+groups+obtained+three+fetal+rats+with+NTD%3B+all+fetal+in+PC+group+were%0D%0Anormal%3B+all+fetal+in+P1+group+were+normal%3B+all+fetal+in+P2+groups+were+normal%3B+all+fetal+in%0D%0AP3+were+normal.+Data+were+analyzed+using+Kruskal-Wallis+non+parametric+test+and%0D%0Aobtained+significant+value+of+p%3D0%2C080.%0D%0AConclusion%3A+There+are+no+difference+in+the+effects+of+folic+acid+on+various+administration%0D%0Aperiods+against+NTD+incidence+of+fetal+rats+(Rattus+norvegicus)+strains+Sprague+dawley.%0D%0AKey+words%3A+Folic+acid%2C+Neural+Tube+Defect%2C+Pregnancy%2C+Rat&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2017-01-10&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25290%2F1%2FABSTRACT%2520ABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25290%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25290%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=+++ANALIA%2C+(1318011009)++(2017)+PERBANDINGAN+EFEK+PEMBERIAN+ASAM+FOLAT+SELAMA+KEHAMILAN+TERHADAP+KEJADIAN+NEURAL+TUBE+DEFECTS+(NTD)+PADA+FETUS+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+SPRAGUE+DAWLEY.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F25290%2F