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<http://digilib.unila.ac.id/id/eprint/25311> <http://purl.org/dc/terms/title> "UJI AKTIVITAS α-GLUCOSIDASE INHIBITOR DAN ANTIOKSIDAN\r\nPADA DAUN JAMBU BIJI, DAUN JAMBU METE DAN\r\nKOMBINASINYA SEBAGAI PENGEMBANGAN BAHAN\r\nANTIDIABETES"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://digilib.unila.ac.id/id/eprint/25311> <http://purl.org/ontology/bibo/abstract> "Latar belakang: Diabetes Mellitus (DM) merupakan gangguan metabolik menahun yang\r\nditandai keadaan hiperglikemia. Salah satu golongan obat yang digunakan untuk menjaga\r\nkadar glukosa darah pada penderita DM adalah golongan α-glucosidase inhibitor.\r\nSedangkan penggunaan antioksidan bertujuan untuk menurunkan resiko terjadinya\r\nkomplikasi pada penderita DM. Daun jambu biji dan daun jambu mete diduga memiliki\r\nefek sebagai α-glucosidase inhibitor dan antioksidan sehingga sangat berpotensi untuk\r\ndikembangkan menjadi bahan dasar terapi DM.\r\nMetode penelitian: Penelitian ini merupakan penelitian eksperimental dengan desain\r\nRancangan Acak Kelompok Lengkap (RAKL). Penelitian ini dilakukan secara in vitro\r\ndengan menggunakan metode pengukuran spektrofotometri pada λ = 517 nm untuk\r\nmenguji kandungan antioksidan dan λ = 405 nm untuk uji aktivitas α-glucosidase inhibitor.\r\nData pada penelitian ini diuji menggunakan uji Beda Nyata Terkceil 5%.\r\nHasil penelitian: Hasil menunjukkan bahwa ekstrak daun jambu biji memiliki aktivitas α-\r\nglucosidase inhibitor tertinggi sebesar 97,006 % dengan nilai IC50 sebesar 2,16 mg/ml dan\r\naktivitas antioksidan sebesar 97,992 %. Pencampuran ekstrak tidak memiliki perbedaan\r\nnyata baik pada hasil aktivitas antioksidan dan aktivitas α-glucosidase inhibitor.\r\nSimpulan: Ekstrak daun jambu biji dan daun jambu mete memiliki aktivitas α-glucosidase\r\ninhibitor dan antioksidan. Ekstrak daun jambu biji merupakan ekstrak dengan aktivitas α-\r\nglucosidase inhibitor dan antioksidan tertinggi. Pencampuran ekstrak tidak memiliki\r\npengaruh terhadap aktivitas α-glucosidase inhibitor dan aktivitas antioksidan.\r\nKata kunci: Antidiabetes, antioksidan, daun jambu biji, daun jambu mete, α-glucosidase\r\ninhibitor\r\n\r\nABSTRACT\r\n\r\nBackground: Diabetes Mellitus (DM) is a group of chronic metabolic disease\r\ncharacterized by hyperglycemic. α-Glucosidase inhibitor is one of antidiabetic drugs used\r\nin diabtic therapy to maintain blood glucose in patients with DM. The use of antioxidants\r\nis aimed to reduce the risk of complications in patients with DM. Guava and cashew leaf\r\nextract suspected to have the effect as α-glucosidase inhibitor and antioxidants so it has the\r\npotential to be developed as antidiabetic agent.\r\nMethods: This study was an experimental study with randomized complete block design\r\n(RCBD) technique. This study was an in vitro model with spectrophotometric method to\r\nanalyze sample with λ= 517 nm for antioxidant analysis and λ= 405 nm for the activity of\r\nα-glucosidase inhibitor.\r\nResults: The result showed that guava leaf extract had the highest α-glucosidase inhibitor\r\nactivity by 97,006 % inhibition with IC50 = 2,16 mg/ml and antioxidant activity by 97,992\r\n% on scavenging DPPH. The combination of guava leaf extract and cashew leaf extract did\r\nnot give some effect on antioxidant activity or α-glucosidase inhibitor activity.\r\nConclusion: Guava leaf extract and cashew leaf extract had α-glucosidase inhibitor activity\r\nand antioxidant activity. Guava leaf extract had the highest of α-glucosidase inhibitor and\r\nantioxidant activity.Combination of the extracts did not give some effect on antioxidant\r\nactivity or α-glucosidase inhibitor activity.\r\nKeywords: Antidiabetic, antioxidant, cashew leaf, guava leaf, α-glucosidase inhibitor"^^<http://www.w3.org/2001/XMLSchema#string> .
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