?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EFEK+TOKSIK+EKSTRAK+ETANOL+96%25+BIJI+JENGKOL+(Pithecollobium+lobatum+benth)+TERHADAP+GAMBARAN+HISTOPATOLOGI+HEPAR+dan+KADAR+SGPT+(Serum+Glutamic+Pyruvate+Transaminase)+serta+SGOT+(Serum+Glutamic+Oxaloacetic+Transaminase)+TIKUS+PUTIH+(Rattus+norvegicus)%0D%0AJANTAN+GALUR+SPRAGUE+DAWLEY&rft.creator=Restu+Pamanggih%2C+1318011138&rft.subject=Q+Science+(General)&rft.description=Latar+Belakang.+Di+Indonesia+banyak+tumbuhan+yang+digunakan+sebagai+obat+herbal+salah+satu+diantaranya+adalah+biji+jengkol.+Jengkol+diduga+memiliki+efek+samping+yang+buruk+terhadap+organ+tubuh%2C+salah+satunya+adalah+hepar.+Untuk+mendiagnosis+adanya+kerusakan+sel+hepar%2C+dilakukanlah+pemeriksaan+histopatologi+hepar+serta+pemeriksaan+enzim+SGPT+serta+SGOT+.+Tujuan+dari+penelitian+ini+adalah+untuk+mengetahui+efek+toksik+ekstrak+etanol+96%25+biji+jengkol+terhadap+gambaran+histopatologi+hepar+dan+kadar+enzim+SGPT+serta+SGOT.%0D%0AMetode.+Penelitian+ini+adalah+penelitian+eksperimental+dengan+rancangan+Post+Test+Only+Control+Group+Design.+Sampel+dalam+penelitian+ini+adalah+tikus+putih+(Rattus+norvegicus)+jantan+galur+Sprague+Dawley%2C+berjumlah+20+ekor+yang+dibagi+menjadi+4+kelompok%2C+yaitu+kelompok+kontrol+negatif+(diberikan+aquades)%2C+perlakuan+1+(diberikan+dosis+ekstrak+jengkol+1200+mg%2FkgBB)%2C+perlakuan+2+(diberikan+dosis+ekstrak+jengkol+2400+mg%2FkgBB)%2C+perlakuan+3+(diberikan+dosis+ekstrak+jengkol+4800+mg%2FkgBB)+selama+14+hari.+Kemudian+dilakukan+pengambilan+darah+tikus+dengan+teknik+pungsi+transkardial+untuk+dilakukan+pemeriksaan+kadar+enzim+SGPT+dan+SGOT%2C+serta+dilakukan+pembedahan+untuk+pengambilan+organ+hepar+yang+akan+digunakan+untuk+pemeriksaan+histopatologi.%0D%0AHasil.+Berdasarkan+hasil+uji+Oneway+ANOVA%2C+diperoleh+nilai+p%3D0%2C001+terhadap+gambaran+histopatologi+hepar+tikus%2C+sedangkan+terhadap+kadar+SGPT+dan+SGOT%2C+diperoleh+nilai+p%3D0%2C001+dan+p%3D0%2C001.+Hal+ini+menyatakan+bahwa+pemberian+ekstrak+etanol+biji+jengkol+berpengaruh+terhadap+gambaran+histopatologi%2C+SGPT%2C+dan+SGOT.+Dosis+1200+mg%2FkgBB%2C+2400+mg%2FkgBB%2C+dan+4800+mg%2FkgBB+berpengaruh+terhadap+kerusakan+histopatologi+hepar+dan+kadar+SGPT%2C+sedangkan+pada+SGOT+hanya+dosis+2400+mg%2FkgBB+dan+4800+mg%2FkgBB+yang+memiliki+pengaruh.%0D%0AKesimpulan.+Terdapat+efek+toksik+pemberian+ekstrak+etanol+96%25+biji+jengkol+terhadap+gambaran+histopatologi+hepar+dan+kadar+enzim+SGPT+serta+SGOT.%0D%0AKata+Kunci%3A+Hepar%2C+Histopatologi%2C+Jengkol%2C+SGOT%2C+SGPT%0D%0A%0D%0A%0D%0A%0D%0AABSTRACT%0D%0A%0D%0ABackground.+In+Indonesia%2C+there+are+many+plants+used+as+herbal+remedies%2C+one+of+which+is+Pithecollobium+lobatum+benth.+However%2C+there+was+an+assumtion+that+Pithecollobium+lobatum+benth+also+have+bad+side+effects+to+the+body's+organs%2C+one+of+which+is+the+liver.+In+order+to+diagnose+the+damage+of+liver+cells%2C+histopathological+examination+of+the+liver+and+test+of+SGPT+and+SGOT+enzymes+is+needed.+The+objective+of+this+research+is+to+know+the+toxic+effects+of+96%25+ethanol+extract+of+Pithecollobium+lobatum+benth+toward+liver+histopathology+overview+and+levels+of+SGPT+and+SGOT+enzymes.%0D%0AMethod.+This+study+is+an+experimental+research+with+Post+Test+Only+Control+Group+Design.+The+sample+in+this+study+was+a+male+white+rat+(Rattus+norvegicus)+Sprague+Dawley+strain%2C+there+are+20+rats+that+were+divided+into+4+groups%2C+there+are+the+negative+control+group%2C+treatment+1+(given+doses+of+extract+Pithecollobium+1200+mg%2Fkg)%2C+treatment+2+(given+doses+of+extract+Pithecollobium+2400+mg%2Fkg)%2C+treatment+3+(given+doses+of+extract+Pithecollobium+4800+mg%2Fkg)+for+14+days.+The+rats%E2%80%99+blood+was+taken+from+transcardial+punction+to+examine+the+SGPT+and+SGOT+enzymes+levels%2C+after+that+the+surgery+was+needed+to+take+liver+organ+for+histopathological+examination.%0D%0AResults.+Based+on+the+test+results+one+way+ANOVA%2C+the+result+showed+the+value+of+p%3D0.001+for+rat+hepatic+histopathology%2C+whereas+the+levels+of+SGPT+and+SGOT%2C+the+result+showed+the+value+of+p%3D0.001+and+p%3D0.001.+It+is+claimed+that+the+96%25+ethanol+extract+Pithecollobium+lobatum+benth+have+the+toxic+effects+with+histopathology+liver%2C+SGPT%2C+and+SGOT.+The+doses+of+1200+mg%2FkgBB%2C+2400+mg%2FkgBB%2C+and+4800+mg%2FkgBB+affect+the+liver+histopathological+damage+and+SGPT%2C+whereas+doses+of+2400+mg%2FkgBB+and+4800+mg%2FkgBB+in+SGOT+of+Sprague+Dawley+rats.%0D%0AConclusion.+There+is+the+toxic+effects+96%25+ethanol+extract+of+Pithecollobium+lobatum+benth+on+liver+histopathology+and+levels+of+SGPT+also+SGOT+enzymes.%0D%0AKeywords%3A+Histopathology%2C+Liver%2C+Pithecollobium+lobatum+benth%2C+SGOT%2C+SGPT&rft.publisher=UNIVERSITAS+LAMPUNG&rft.date=2017-01-24&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25366%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25366%2F20%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25366%2F19%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Restu+Pamanggih%2C+1318011138++(2017)+EFEK+TOKSIK+EKSTRAK+ETANOL+96%25+BIJI+JENGKOL+(Pithecollobium+lobatum+benth)+TERHADAP+GAMBARAN+HISTOPATOLOGI+HEPAR+dan+KADAR+SGPT+(Serum+Glutamic+Pyruvate+Transaminase)+serta+SGOT+(Serum+Glutamic+Oxaloacetic+Transaminase)+TIKUS+PUTIH+(Rattus+norvegicus)+JANTAN+GALUR+SPRAGUE+DAWLEY.++UNIVERSITAS+LAMPUNG%2C+FAKULTAS+KEDOKTERAN.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F25366%2F