?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EFEK+PROTEKTIF+THYMOQUINONE+TERHADAP+GAMBARAN+HISTOPATOLOGI+HEPAR+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+Sprague+dawley+YANG+DIINDUKSI+RIFAMPISIN&rft.creator=VICTORIA+HAWARIMA%2C++1318011174&rft.subject=R+Medicine+(General)&rft.description=Latar+Belakang%3A+Hepar+merupakan+organ+terbesar+pada+tubuh%2C+menyumbang+sekitar+2+persen+berat+tubuh+total.+Kerusakan+pada+hepar+dapat+disebabkan+oleh+obat-obatan%2C+salah+satunya+adalah+rifampisin.+Rifampisin+memiliki+efek++hepatotoksik%2C+efek+toksik+rifampisin+terkait+stres+oksidatif+dan+sitokin+proinflamasi.+Bahan+aktif+dari+jintan+hitam%2C+yaitu+thymoquinone+memiliki+efek+hepatoprotektif+melalui+mekanisme+sebagai+antioksidan+dan+antiinflamasi.+%0D%0ATujuan%3A+Untuk+mengetahui+adanya+efek+protektif+thymoquinone+terhadap+gambaran+histopatologi+hepar+tikus+yang+diinduksi+rifampisin+dan+untuk+mengetahui+adanya+pengaruh+peningkatan+dosis+thymoquinone+pada+efek+protektif+terhadap+gambaran+histopatologi+hepar+tikus+yang+diinduksi+rifampisin.%0D%0AMetode%3A+Penelitian+ini+menggunakan+25+ekor+tikus+putih+(Rattus+norvegicus)+jantan+galur+Sprague+dawley+yang+dibagi+ke+dalam+5+kelompok+dan+diberi+perlakuan+selama+14+hari.+K1+(kontrol+negatif+yang+hanya+diberi+akuades)%2C+K2+(kontrol+positif+yang+hanya+diberi+rifampisin+1+g%2FkgBB)%2C+P1+(perlakuan+1+yang+diberi+rifampisin+1+g%2FkgBB+dan+thymoquinone+5+mg%2FkgBB)%2C+P2+(perlakuan+2+yang+diberi+rifampisin+1+g%2FkgBB+dan+thymoquinone+10+mg%2FkgBB)%2C+dan+P3+(perlakuan+3+yang+diberi+rifampisin+1+g%2FkgBB+dan+thymoquinone+20+mg%2FkgBB).%0D%0AHasil%3A+Hasil+rerata+persentasi+degenerasi+bengkak+keruh+hepatosit+adalah+K1%3A+1%2C8%25%2C+K2%3A+37%2C6%25%2C+P1%3A+2%25%2C+P2%3A+1%2C8%25%2C+dan+P3%3A+6%2C64%25.+Pada+P1%2C+P2%2C+dan+P3+mengalami+penurunan+jika+dibandingkan+dengan+K2.%0D%0ASimpulan%3A+Terdapat+efek+protektif+thymoquinone+pada+dosis+5%2C+10%2C+dan+20+mg%2FkgBB+dan+terdapat+efek+protektif+dengan+peningkatan+dosis+dari+5+menjadi+10+mg%2FkgBB+namun+tidak+terjadi+pada+dosis+20+mg%2FkgBB.%0D%0A%0D%0AKata+kunci%3A+hepar%2C+rifampisin%2C+thymoquinone%0D%0A%0D%0A%0D%0A%0D%0AABSTRACT%0D%0A%0D%0ABackground%3A+The+liver+is+the+largest+organ+in+the+body%2C+accounting+for+about+2+percent+of+total+body+weight.+Damage+to+the+liver+can+be+caused+by+drugs%2C+one+of+them+is+rifampicin.+Rifampicin+has+hepatotoxic+effects%2C+toxic+effects+of+rifampicin+related+oxidative+stress+and+proinflammatory+cytokines.+The+active+ingredients+of+black+cumin%2C+namely+thymoquinone+have+hepatoprotective+effects+through+a+mechanism+as+an+antioxidant+and+anti-inflammatory.%0D%0AObjective%3A+To+investigate+the+protective+effect+of+thymoquinone+to+liver+histopathology+of+rat+induced+rifampicin+and+to+determine+the+effect+of+increasing+doses+of+thymoquinone+to+protective+effects+against+liver+histopathological+of+rat+induced+rifampicin.+%0D%0AMethods%3A+This+study+used+25+rats+(Rattus+norvegicus)+male+Sprague+dawley+were+divided+into+five+groups+and+were+treated+for+14+days.+K1+(negative+control+which+was+only+given+distilled+water)%2C+K2+(positive+control+which+is+only+given+rifampicin+1+g%2FkgBW)%2C+P1+(treatment+1+by+rifampicin+1+g%2FkgBW+and+thymoquinone+5+mg%2FkgBW)%2C+P2+(treatment+2+by+rifampicin+1+g%2FkgBW+and+thymoquinone+10+mg%2FkgBW)%2C+and+P3+(treatment+3+by+rifampicin+1+g%2FkgBW+and+thymoquinone+20+mg%2FkgBW).%0D%0AResults%3A+The+average+percentage+of+cloudy+swelling+degeneration+of+hepatocytes+are+K1%3A+1%2C8%25%2C+K2%3A+37%2C6%25%2C+P1%3A+2%25%2C+P2%3A+1%2C8%25%2C+and+P3%3A+6%2C64%25.+In+P1%2C+P2%2C+and+P3+has+decreased+when+compared+with+the+K2.%0D%0AConclusion%3A+There+is+a+protective+effect+thymoquinone+at+doses+of+5%2C+10%2C+and+20+mg%2FkgBW+and+there+is+a+protective+effect+with+increased+doses+of+5+to+10+mg%2FkgBW+but+does+not+occur+at+a+dose+of+20+mg%2FkgBW.%0D%0A%0D%0AKeywords%3A+liver%2C+rifampicin%2C+thymoquinone%0D%0A&rft.publisher=UNIVERSITAS+LAMPUNG&rft.date=2017-01-23&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25395%2F19%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25395%2F20%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25395%2F21%2FSKRIPSI%2520FULL.pdf&rft.identifier=++VICTORIA+HAWARIMA%2C+1318011174++(2017)+EFEK+PROTEKTIF+THYMOQUINONE+TERHADAP+GAMBARAN+HISTOPATOLOGI+HEPAR+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+Sprague+dawley+YANG+DIINDUKSI+RIFAMPISIN.++UNIVERSITAS+LAMPUNG%2C+FAKULTAS+KEDOKTERAN.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F25395%2F