?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EFEK+PROTEKTIF+THYMOQUINONE+TERHADAP+GAMBARAN+HISTOPATOLOGI+GINJAL+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+Sprague+dawley+YANG+DIINDUKSI+RIFAMPISIN++&rft.creator=RIKA+OKTARIA%2C+1318011142&rft.subject=R+Medicine+(General)&rft.description=++%0D%0AABSTRACT+%0D%0A+%0D%0A+PROTECTIVE+EFFECT+OF+THYMOQUINONE+ON+KIDNEY+%0D%0AHISTOPHATOLOGY+APPEARANCE+OF+Sprague+dawley+STRAIN+WHITE+RAT+(Rattus+novergicus)+INDUCED+RIFAMPICIN+%0D%0A+%0D%0ABy+Rika+Oktaria+%0D%0A++%0D%0ABackground%3A+Rifampicin+is+one+of+the+firt-line+therapy+from+Tuberculosis.+The+increase+of+Tuberculosis+cases+every+year+also+cause+the+use+of+rifampicin+highly+increase.+The+excessive+use+of+rifampicin+can+give+side+effects+such+as+kidney+damage.+Damage+to+the+kidney+can+be+treated+with+antioxidant+compounds.+One+of+the+compounds+that+can+be+used+is+thymoquinone.+This+study+aims+to+find+out+whether+thymoquinone+can+give+protective+effect+on+kidney+histophatology+appearance+of+Sprague+dawley+strain+white+rat+(Rattus+novergicus)+induced+rifampicin.+Methods%3A+This+study+is+an+experimental+study+using+25+male+white+rats+which+was+divided+into+5+groups%3A+K1+(rats+with+no+treatments)%2C+K2+(rats+given+rifampicin+100mg%2F100gBB)%2C+P1%2C+P2+and+P3+(given+rifampicin+100+mg%2F100gBB+and+thymoquinone+in+different+doses%3A+5+mg%2FkgBB%2C+10+mg%2FkgBB+and+20+mg%2FkgBB)+for+14+days.+Results%3A+The+result+of+this+study+shows+that+the+average+score+of+kidney+damage+are+K1%3A+1%2C28%2C+K2%3A+3%2C16%2C+P1%3A+2%2C08%2C+P2%3A+2%2C12%2C+P3%3A+2%2C88.+The+data+obtained+is+examined+by+KruskalWallis%0D%0Atest%0D%0A%0D%0Awhich+showed+significant+difference+p%3D0%2C02+(p%3C0%2C05).+This+conclusion+of+this+study+is+that+there+is+thymoquinone+protective+effect+on+kidney+histophatology+appearance+of+Sprague+dawley+strain+white+rat+(Rattus+novergicus)+induced+rifampicin.+Keywords%3A+kidney+histopathology%2C+rifampicin%2C+thymoquinone+%0D%0A+%0D%0A+++%0D%0AABSTRAK+++%0D%0AEFEK+PROTEKTIF+THYMOQUINONE+TERHADAP+GAMBARAN+HISTOPATOLOGI+GINJAL+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+Sprague+%0D%0Adawley+YANG+DIINDUKSI+RIFAMPISIN+++%0D%0A++%0D%0AOleh+Rika+Oktaria+%0D%0ALatar+Belakang%3A+Rifampisin+merupakan+salah+satu+terapi+lini+pertama+dari+Tuberkulosis.+Peningkatan+kasus+Tuberkulosis+setiap+tahun+menyebabkan+penggunaan+rifampisin+juga+sangat+tinggi.+Penggunaan+rifampisin+yang+berlebihan+dapat+menyebabkan+efek+samping+berupa+kerusakan+ginjal.+Kerusakan+pada+ginjal+tersebut+dapat+diatasi+dengan+senyawa+antioksidan.+Salah+satu+antioksidan+yang+dapat+digunakan+adalah+thymoquinone.+Penelitian+ini+bertujuan+untuk+mengetahui+apakah+thymoquinone+dapat+memberikan+efek+protektif+terhadap+gambaran+histopatologi+ginjal+tikus+putih+(Rattus+novergicus)+galur+Sprague+dawley+yang+diinduksi+rifampisin.+Metode%3A+Penelitian+ini+merupakan+penelitian+ekperimental+menggunakan+25+ekor+tikus+putih+galur+Sprague+dawley+yang+dibagi+ke+dalam+5+kelompok%2C+yaitu+kontrol+1+(K1)+tikus+yang+tidak+diberikan+perlakuan%2C+kontrol+2+(K2)+diberikan+rifampisin+dosis+100+mg%2F100gBB%2C+P1%2C+P2+dan+P3+diberikan+rifampisin+100+mg%2F100gBB+dan++thymoquinone+dengan+dosis+berbeda+yaitu+5+mg%2FkgBB%2C+10+mg%2FkgBB+dan+20+mg%2FkgBB++dalam+waktu+14+hari.++Hasil%3A+Hasil+penelitian+menunjukan+bahwa+rerata+skor+kerusakan+ginjal+pada+K1%3A+1%2C28%2C+K2%3A+3%2C16%2C+P1%3A+2%2C08%2C+P2%3A+2%2C12%2C+P3%3A+2%2C88.+Data+yang+diperoleh+diuji+dengan+Uji+KruskalWallis%0D%0A%0D%0Adidapatkan+perbedaan+bermakna+p%3D+0%2C02+(p%3C0%2C05).+Kesimpulan+dari+penelitian+ini+adalah+terdapat+efek+protektif+thymoquinone+terhadap+gambaran+histopatologi+ginjal+tikus+putih+(Rattus+novergicus)+galur+Sprague+dawley+yang+diinduksi+rifampisin.+Kata+Kunci%3A+histopatologi+ginjal%2C+rifampisin%2C+thymoquinone+%0D%0A+&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2017-01-30&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25411%2F1%2FABSTRAK%2520%2528INGGRIS%2520%2526%2520INDONESIA%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25411%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F25411%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++RIKA+OKTARIA%2C+1318011142++(2017)+EFEK+PROTEKTIF+THYMOQUINONE+TERHADAP+GAMBARAN+HISTOPATOLOGI+GINJAL+TIKUS+PUTIH+(Rattus+norvegicus)+GALUR+Sprague+dawley+YANG+DIINDUKSI+RIFAMPISIN.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F25411%2F