?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EFEKTIVITAS+ANTIKANKER+EKSTRAK+ETANOL+DAUN+KENIKIR+%0D%0A(Cosmos+caudatus+Kunth.)+DAN+TAURIN+TERHADAP+RESPON+HISTOPATOLOGI+HEPAR+MENCIT+JANTAN+(Mus+musculus+L.)%0D%0AYANG+DIINDUKSI+BENZO(%CE%B1)PIREN+%0D%0A&rft.creator=IFFA+AFIQA+KHAIRANI%2C+1317021038&rft.subject=QH301+Biology&rft.description=ABSTRAK%0D%0A%0D%0AKanker+merupakan+penyakit+yang+ditandai+dengan+adanya+pertumbuhan+abnormal+sel+secara+terus+menerus+dan+tidak+terkendali.++Berbagai+bahan+alami+diperlukan+sebagai+upaya+mengurangi+efek+samping+dari+penggunaan+obat-obatan+kimia+dalam+terapi+penyembuhan+kanker.++Tumbuhan+Kenikir+(Cosmos+caudatus+Kunth.)+mengandung+antioksidan+cukup+tinggi+yang+mampu+menghambat+karsinogenesis+dengan+memacu+proses+apoptosis+pada+sel+kanker.++Disamping+itu%2C+taurin+(golongan+asam+organik)+juga+bersifat+sebagai+antioksidan+dan+antikarsinogenik+karena+mampu+melindungi+sel-sel+tubuh+dari+kerusakan+yang+disebabkan+oleh+radikal+bebas.++Tujuan+dari+penelitian+ini+adalah+menguji+efektivitas+antikanker+dari+ekstrak+etanol+daun+kenikir+dan+taurin+terhadap+gambaran+histopatologi+hepar+mencit+jantan+yang+diinduksi+benzo(%CE%B1)piren.%0D%0APenelitian+ini+menggunakan+Rancangan+Acak+Lengkap+yang+terbagi+dalam+4+kelompok+perlakuan+dengan+masing-masing+6+ulangan.+Kelompok+K1+(diberi+pakan+standar+dan+air+minum+hingga+akhir+penelitian)%2C+K2+(diinduksi+dengan+benzo(%CE%B1)piren+secara+subkutan+dengan+dosis+0%2C3+mg%2Fbb+selama+10+hari+tanpa+pemberian+bahan+uji)%2C+K3+(setelah+diinduksi+benzo(%CE%B1)piren%2C+diberi+ekstrak+etanol+daun+kenikir+dengan+dosis+20%2C2+mg%2Fbb+selama+15+hari)+dan+K4+(setelah+diinduksi+benzo(%CE%B1)piren%2C+diberi+taurin+sebanyak+15%2C6+mg%2Fbb+yang+dikombinasikan+dengan+ekstrak+etanol+daun+kenikir+sebesar+20%2C2+mg%2Fbb+selama+15+hari).+Hasil+analisis+dengan+One+Way+ANOVA+dan+dilanjutkan+BNT+pada+taraf+nyata+5%25+menunjukkan+pemberian+taurin+yang+dikombinasikan+dengan+ekstrak+etanol+daun+kenikir+merupakan+dosis+yang+efektif+untuk+melindungi+kerusakan+jaringan+hepar+mencit+akibat+pemberian+benzo(%CE%B1)piren.+%0D%0A%0D%0AKata+kunci+%3A+Cosmos+caudatus+Kunth.%2C+taurin%2C+Mus+musculus+L.%2C+benzo(%CE%B1)piren%2Chistopatologi+hepar%0D%0A%0D%0A%0D%0AABSTRACT%0D%0A%0D%0ACancer+is+a+disease+characterized+by+the+continuously+proliferate+of+cell%2C+so+that+generate+abnormal+tissue+growth.+Various+natural+ingredients+needed+as+an+alternative+to+reduce+the+bad+effect+of+chemical+drugs+consumption+on+cancer+chemotherapies.+Kenikir+(Cosmos+caudatus+Kunth.)+contains+high+antioxidants+that+can+inhibit+carcinogenesis+by+inducing+the+process+of+apoptosis+in+cancer+cells.+In+addition%2C+taurine+(an+organic+acid+group)+also+act+as+an+antioxidant+and+anticancer+by+protect+a+cells+from+the+damage+caused+by+free+radicals.+The+aim+of+this+study+was+to+determine+the+anticancer+effectivity+of+kenikir+leaves+ethanolic+extract+and+taurine+on+the+hepar+histopathology+of+male+mice+induced+by+benzo(%CE%B1)pyrene.%0D%0A%09This+study+was+conducted+in+a+complete+randomized+design+by+using+four+treatments+(K1%2C+K2%2C+K3+and+K4)%2C+each+in+six+replications.+K1+used+as+control+were+not+given+any+treatment.+K2+were+induced+by+0%2C3+mg%2Fbw+benzo(%CE%B1)pyrene+subcutaneously+for+10+days+without+being+given+kenikir+extract+nor+taurine.+K3+were+given+20%2C2+mg%2Fbw+of+kenikir+leaves+extract+for+15+days+after+being+induced+by+benzo(%CE%B1)pyrene.+K4+were+given+15%2C6+mg%2Fbw+of+taurine+which+was+combined+by+20%2C2+mg%2Fbw+of+kenikir+leaves+extract+for+15+days+after+being+induced+by+benzo(%CE%B1)pyrene.+The+data+were+analyzed+using+ANOVA+(Analysis+of+Variance)+then+continued+by+calculating+least+significant+difference+at+0%2C05+level+of+significance.+The+results+indicated+that+taurine+which+was+combined+by+kenikir+leaves+ethanolic+extract+had+the+ability+to+protect+hepar+form+the+damage+caused+by+benzo(%CE%B1)pyrene.%0D%0A%0D%0AKeywords%3A+Cosmos+caudatus+Kunth.%2C+taurine%2C+Mus+musculus+L.%2C+benzo(%CE%B1)pyrene%2C+hepar+histophatology.%0D%0A%0D%0A&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2017-04-04&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F26252%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F26252%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F26252%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++IFFA+AFIQA+KHAIRANI%2C+1317021038++(2017)+EFEKTIVITAS+ANTIKANKER+EKSTRAK+ETANOL+DAUN+KENIKIR+(Cosmos+caudatus+Kunth.)+DAN+TAURIN+TERHADAP+RESPON+HISTOPATOLOGI+HEPAR+MENCIT+JANTAN+(Mus+musculus+L.)+YANG+DIINDUKSI+BENZO(%CE%B1)PIREN.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F26252%2F