?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=+%0D%0AEFEK+ANTIOKSIDAN+EKSTRAK+DAUN+RAMBUSA+(Passiflora+foetida)+DAN%0D%0ATAURIN+TERHADAP+RESPON+HISTOPATOLOGI+HATI+MENCIT+YANG+%0D%0ADIINDUKSI+PARAQUAT%0D%0A&rft.creator=RETNO+KHUSNIATI+ROFIQOH%2C+1317021062&rft.subject=QH301+Biology&rft.subject=RS+Pharmacy+and+materia+medica&rft.description=ABSTRAK%0D%0A+%0D%0AParaquat+merupakan+senyawa+toksik+yang+dapat+menginduksi+terbentuknya%0D%0Amolekul+ROS+(ReactiveOxygen+Species).+ROS+yang+terbentuk+akibat+paparan%0D%0Aparaquat+dapat+menurunkan+aktivitas+antioksidan+tubuh%2C+sehingga+menyebabkan%0D%0Akerusakan+pada+berbagai+organ+vital+seperti+hati.+Untuk+mengurangi+kerusakan+yang%0D%0Aditimbulkan+akibat+aktivitas+ROS%2C+diperlukan+sumber+antioksidan+seperti+taurin%0D%0Ayang+mampu+menangkap+radikal+bebas+dan+menghentikan+produksi+molekul+ROS%0D%0Ayang+dihasilkan+akibat+paparan+paraquat.+Selain+taurine%2C+daun+Rambusa+(Passiflora%0D%0Afoetida)+memiliki+kandungan+senyawa+polifenol+dan+flavonoid+yang+berperan%0D%0Asebagai+antioksidan.+Penelitian+ini+bertujuan+untuk+mengetahui+kemampuan+daun%0D%0Arambusa+dan+taurin+dalam+memperbaiki+histopatologi+sel+hepar+mencit+yang%0D%0Amengalami+kerusakan.++%0D%0APercobaan+ini+menggunakan+Rancangan+Acak+Lengkap+(RAL)+yang+terbagi%0D%0Adalam+4+kelompok+perlakuan+dengan+masing-masing+6+ulangan+Kelompok+K0%0D%0A(diberi+pakan+standard+dan+air+minum+hingga+akhir+penelitian)%2C+kelompok+K1%0D%0A(diinduksi+praquat+secara+intraperitoneal+dengan+dosis+20+mg%2FkgBB+sebanyak+6+kali%0D%0Aselama+21+hari)%2C+kelompok+K2+(diinduksi+paraquat+dengan+dosis+20+mg%2FkgBB+secara%0D%0Aintraperitoneal+sebanyak+6+kali+selama+21+hari+dan+rambusa+dengan+dosis%0D%0A500mg%2FkgBB%2Fhari+selama+21+hari)%2C+kelompok+K3+(diinduksi+paraquat+dengan+dosis%0D%0A20+mg%2FkgBB+secara+intraperitoneal+sebanyak+6+kali+selama+21+hari+%2B+rambusa%0D%0Adengan+dosis+500mg%2FkgBB%2Fhari+selama+21+hari%2C+dan+taurin+dengan+dosis+15%2C6%0D%0Amg%2Fmencit%2Fhari+selama+21+hari).+Hasil+analisa+dengan+uji+one+way+Anova+(p%3C0.05)%0D%0Adilanjutkan+dengan+uji+Beda+Nyata+Terkecil+(BNT)%2C+menunjukan+pemberian%0D%0Akombinasi+ekstrak+daun+rambusa+dan+taurine+efektif+dalam+melindungi+jaringan%0D%0Ahepar+mencit+jantan+akibat+induksi+paraquat.+%0D%0A%0D%0AKata+kunci+%3A+Histopatologi+hepar%2C+Paraquat%2CRambusa+ROS%2CTaurin.+%0D%0AABSTRACT%0D%0A+%0D%0AParaquat+is+a+toxic+compound+wich+induce+the+molecules+of+ROS+(Reactive%0D%0AOxygen+Species)++through+a+series+of+cellular+processes.+ROS+formed+by+paraquat+can%0D%0Areduce+the+activity+of+antioxidants+in+the+body%2C+causing+damage+to+vital+organs+such+as%0D%0Athe+liver.+To+reduce+the+damage+of+ROS%E2%80%99s+activity%2C+needed+source+of+antioxidants+such%0D%0Aas+Taurine+which+able+to+capture+free+radicals+and+stop+the+production+of+ROS%0D%0Amolecules+from+paraquat+exposure.+In+addition+to+taurine%2C+Passiflora+foetida+leaves%0D%0Aare+also+a+source+of+antioxidants.+Passiflora+foetida+leaves+contain+polifenol+and%0D%0Aflavonoids+which+act+as+antioxidants.This+study+aims+to+determine+the+effect+of%0D%0APassiflora+foetida+leaves+dan+Taurine+on+the+liver+to+protect+histopathological+of+mice%0D%0Awhich+suffe+from+ROS+damage.++%0D%0AThis+study+was+conducted+in+a+complete+randomized+design+by+using+four%0D%0Atreatments+(K0%2C+K1%2C+K2+and+K3)%2C+each+in+six+replications.+K0+used+as+control+were+not%0D%0Agiven+any+treatment.+K2+were+induced+by+20+mg%2Fbw+paraquat+intraperitonialy+six+time%0D%0Afor+21+days%2C+for+10+days%2C+K2+were+given+20+mg%2Fbw+paraquat+intraperitonialy+six+time%0D%0Afor+21+days%2C+and+500+mg%2Fbw+of+rambusa+leaves+extract+for+21+days.+K3+were+given+20%0D%0Amg%2Fbw+paraquat+intraperitonialy+six+time+for+21+days%2C+given+15%2C6+mg%2Fbw+of+taurine%0D%0Awhich+was+combined+by+500+mg%2Fbw+of+rambusa+leaves+extract.+The+data+were%0D%0Aanalyzed+using+ANOVA+(Analysis+of+Variance)+then+continued+by+calculating+least%0D%0Asignificant+difference+at+0%2C05+level+of+significance.+The+results+indicated+that+taurine%0D%0Awhich+was+combined+by+rambusa+leaves+ethanolic+extract+had+the+ability+to+protect%0D%0Ahepar+form+the+damage+caused+by+paraquat+herbiside.%0D%0A%0D%0A%0D%0A%0D%0AKey+words+%3A+Liver+histopatology%2C+paraquat%2C+Passiflora+foetida%2C+ROS%2C+Taurine.+%0D%0A+&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2017-04-19&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F26405%2F1%2FABSTRACT%2520%2528ABSTRAK%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F26405%2F2%2FSKRIPSI%2520PULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F26405%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++RETNO+KHUSNIATI+ROFIQOH%2C+1317021062++(2017)++EFEK+ANTIOKSIDAN+EKSTRAK+DAUN+RAMBUSA+(Passiflora+foetida)+DAN+TAURIN+TERHADAP+RESPON+HISTOPATOLOGI+HATI+MENCIT+YANG+DIINDUKSI+PARAQUAT.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F26405%2F