TY  - GEN
CY  - UNIVERSITAS LAMPUNG
ID  - eprints26870
UR  - http://digilib.unila.ac.id/26870/
A1  - Della Mita Andini, 1317011011
Y1  - 2017/05/31/
N2  - Sintesis senyawa trifeniltimah(IV) 4-klorobenzoat dan trifeniltimah(IV) 4- hidroksibenzoat telah berhasil dilakukan.   Sintesis diawali dengan mereaksikan senyawa antara trifeniltimah(IV) hidroksida dengan ligan karboksilat yaitu asam
4-klorobenzoat dan asam 4-hidroksibenzoat dalam pelarut metanol dengan perbandingan mol 1:1.  Kedua senyawa yang diperoleh berupa serbuk berwarna putih  dengan  rendemen  masing-masing  98,89%  dan  92,40%.  Senyawa  hasil sintesis telah divalidasi menggunakan spektrofotometer UV-Vis, IR, spektrometer NMR dan microelemental analyzer.   Senyawa hasil sintesis selanjutnya diuji aktivitas  antimalarianya  terhadap  parasit  Plasmodium  falciparum  strain  3D7 secara in vitro.   Hasil pengujian menunjukkan bahwa trifeniltimah(IV) 4- klorobenzoat dan trifeniltimah(IV) 4-hidroksibenzoat berpotensi sebagai obat malaria namun kedua senyawa tersebut kurang efektif jika dibandingkan dengan klorokuin.


Kata  Kunci  :  antimalaria,  Plasmodium  falciparum,  turunan  trifeniltimah(IV)benzoat

ABSTRACT


Synthesis of triphenyltin(IV) 4-chlorobenzoate and triphenyltin(IV) 4- hydroxybenzoate has been successfully performed.  Synthesis was commenced by reacting the triphenyltin(IV) hydroxyde intermediates with the carboxylate ligands as 4-chlorobenzoic acid and 4-hydroxybenzoic acid in methanol with ratio 1:1. Both of the compounds were produced as white solid the yield of 98.89% and
92.40%, respectively.   The yields were validated using UV-Vis, infrared spectrophotometer, NMR spectrometer and microelemental analyzer.   The synthesized compounds were tested of the antimalarial activity towards Plasmodium falciparum strain 3D7 parasite.  Preliminary test result showed that the  triphenyltin(IV)  4-chlorobenzoate  and  triphenyltin(IV)  4-hydroxybenzoate were potential as malarial drugs but they were less effective than chloroquine.




Keyword: antimalarial, Plasmodium falciparum, triphenyltin(IV) benzoate derivatives


PB  - FAKULTAS MATEMATIKA DAN ILMU PENGETAHUAN ALAM
TI  - SINTESIS, KARAKTERISASI, DAN UJI PENDAHULUAN SENYAWA TURUNAN TRIFENILTIMAH(IV) BENZOAT SEBAGAI ANTIMALARIA


AV  - restricted
ER  -