?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=SINTESIS%2C+KARAKTERISASI%2C+DAN+UJI+BIOAKTIVITAS+ANTIMALARIA+SENYAWA+TRIFENILTIMAH(IV)BENZOAT+DAN%09++DIFENILTIMAH(IV)DIBENZOAT+TERHADAP+Plasmodium+falciparum&rft.creator=ISMI+AMBALIKA%2C+1317011030&rft.subject=Q+Science+(General)&rft.subject=QD+Chemistry&rft.description=ABSTRAK%0D%0A%0D%0APada+penelitian+ini+telah+dilakukan+sintesis+senyawa+trifeniltimah(IV)+benzoat+dan+difeniltimah(IV)+dibenzoat+dengan+cara+mereaksikan+senyawa+trifeniltimah(IV)+hidroksida+dan+difeniltimah(IV)+dihidroksida+dengan+senyawa+asam+benzoat+sebagai+ligannya%2C+kemudian+direfluks+pada+suhu+60oC+selama+4+jam.+Senyawa+hasil+sintesis+yang+dihasilkan+berupa+padatan+berwarna+putih+dengan+rendemen+90%2C37%25+dan+89%2C48%25.+Kemurnian+dari+senyawa+sintesis+ini+telah+divalidasi+dengan+karakterisasi+menggunakan+spektrofotometer+IR%2C+UV-Vis%2C+NMR%2C+dan+microelemental+analyzer.+Setelah+itu%2C+uji+aktivitas+antimalaria+dilakukan+pada+parasit+malaria+Plasmodium+falciparum+3D7+dengan+mengukur+nilai+50%25+inhibitor+concentration+(IC50)+dari+masing-masing+senyawa.+Senyawa+trifeniltimah(IV)+benzoat+memiliki+nilai+IC50+0%2C62+%CE%BCg%2FmL+(0%2C13+x+10-5+M)+dan+difeniltimah(IV)+dibenzoat+memiliki+nilai+IC50+1%2C31+%CE%BCg%2FmL+(0%2C25+x+10-5+M).+Besarnya+nilai+IC50+yang+dimiliki+kedua+senyawa+tersebut%2C+menandakan+bahwa+senyawa+trifeniltimah(IV)+benzoat+dan+difeniltimah(IV)+dibenzoat+tergolong+senyawa+yang+sangat+aktif+sebagai+antimalaria+karena+memiliki+nilai+IC50+%3C5+%CE%BCg%2FmL.+Meskipun+kedua+senyawa+tersebut+tergolong+senyawa+yang+sangat+aktif+sebagai+antimalaria%2C+namun+jika+dibandingkan+dengan+klorokuin+sebagai+kontrol+positif%2C+aktivitas+antimalaria+kedua+senyawa+tersebut+kurang+efektif+dibanding+klorokuin+yang+memiliki+nilai+IC50+lebih+kecil+yaitu+0%2C002+%CE%BCg%2FmL+(0%2C62+x+10-8+M).++%0D%0A%0D%0A%0D%0AKata+Kunci+%3A+sintesis%2C+organotimah(IV)+benzoat%2C+antimalaria%2C+P.+falciparum%2C+IC50+%0D%0A%0D%0AABSTRACT%0D%0A%0D%0AIn+this+research%2C+triphenyltin(IV)+benzoate+and+diphenyltin(IV)+dibenzoate+have+been+synthesized+by+the+reaction+between+triphenyltin(IV)+hydroxide+and+diphenyltin(IV)+dihydroxide+with+benzoic+acid+compound+as+ligand%2C+then+refluxing+at+60+%C2%B0+C+for+4+hours.+The+resulting+compound+of+this+synthesis+is+white+solid++with+yield+of+90.37%25+and+89.48%25.+The+purity+of+the+compound+has+been+validated+by+characterization+using+IR%2C+UV-Vis%2C+NMR+spectrophotometers%2C+and+microelemental+analyzer.+Then%2C+the+antimalarial+activity+test+was+performed+for+malaria+parasite+Plasmodium+falciparum+3D7+by+measuring+the+value+of+50%25+concentration+inhibitor+(IC50)+of+each+compound.+Triphenyltin(IV)+benzoate+has+an+IC50+value+of+0.62+%CE%BCg+%2F+mL+(0.13x10-5+M)+and+diphenyltin(IV)+dibenzoate+has+an+IC50+value+of+1.31+%CE%BCg+%2F+mL+(0.25%C3%9710-5+M).+The+value+of+IC50+of+both+compounds%2C+indicating+that+triphenyltin(IV)+benzoate+and+diphenyltin(IV)+dibenzoate+was+classified+as+a+very+active+compound+as+antimalarial+because+it+has+IC50+%3C5+%CE%BCg+%2F+mL.+Although+both+of+compounds+are+very+active+as+antimalarial%2C+but+when++the+compounds+are+compared+to+chloroquine+as+a+positive+control%2C+the+antimalarial+activity+of+the+two+compounds+is+less+effective+than+chloroquine+which+has+a+smaller+IC50+value+of+0.002+%CE%BCg+%2F+mL+(0.62x10-8+M+).%0D%0A%0D%0A%0D%0AKeywords%3A+synthesis%2C+organotin(IV)+benzoate%2C+antimalarial%2C+P.+falciparum%2C+IC50%0D%0A%0D%0A%0D%0A&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2017-05-31&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F26872%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F26872%2F19%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F26872%2F20%2FSKRIPSI%2520FULL%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++ISMI+AMBALIKA%2C+1317011030++(2017)+SINTESIS%2C+KARAKTERISASI%2C+DAN+UJI+BIOAKTIVITAS+ANTIMALARIA+SENYAWA+TRIFENILTIMAH(IV)BENZOAT+DAN+DIFENILTIMAH(IV)DIBENZOAT+TERHADAP+Plasmodium+falciparum.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F26872%2F