?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=SINTESIS%2C+KARAKTERISASI%2C+DAN+UJI+BIOAKTIVITAS+SENYAWA+TRIFENILTIMAH(IV)+2-+DAN+4-+HIDROKSIBENZOAT+TERHADAP+PARASIT+Plasmodium+falciparum+SECARA+IN+VITRO&rft.creator=FEBRI+ARDHIYANSYAH%2C+1317011023&rft.subject=Q+Science+(General)&rft.description=ABSTRAK%0D%0A%0D%0APada+penelitian+ini+telah+dilakukan+sintesis+senyawa+trifeniltimah(IV)+2-+hidroksibenzoat+++dan+++trifeniltimah(IV)+++4-hidroksibenzoat+++dengan+++mereaksikan+senyawa+trifeniltimah(IV)+klorida+dan+NaOH+menghasilkan+trifeniltimah(IV)+hidroksida.+++Selanjutnya%2C+trifeniltimah(IV)+hidroksida+direaksikan+dengan+asam+2-+hidroksibenzoat+dan+asam+4-hidroksibenzoat+dengan+berat+masing-masing+rendemen+senyawa+79%2C39%25+dan+89%2C26%25.++Senyawa+hasil+sintesis+dikarakterisasi+menggunakan+spektrofotometer++IR%2C++UV-Vis%2C++NMR%2C++dan++microelemental++analyzer++menunjukkan+bahwa+senyawa+hasil+sintesis+telah+murni.+Pengujian+antimalaria+terhadap+parasit+Plasmodium+falciparum+diperoleh+hasil+bahwa+senyawa+trifeniltimah(IV)+4-+hidroksibenzoat+++lebih+++efektif+++dibandingkan+++trifeniltimah(IV)+++2-hidroksibenzoat+dengan+nilai+IC50+masing-masing+3%2C55+%C2%B5g%2FmL+dan+9%2C01+%C2%B5g%2FmL.++Kedua+senyawa+ini+tergolong+senyawa+yang+aktif+sebagai+antimalaria+karena+memiliki+nilai+IC50++%E2%89%A450%0D%0A%C2%B5g%2FmL.+++++Namun%2C++jika++dibandingkan++dengan++klorokuin++sebagai++kontrol++positif%2C+aktivitas+antimalaria+kedua+senyawa+ini+tidak+lebih+efektif+dari+klorokuin+yang+memiliki+nilai+IC50+0%2C002+%C2%B5g%2FmL.%0D%0A%0D%0A%0D%0A%0D%0AKata+Kunci+%3A+Sintesis%2C+trifeniltimah(IV)+2-hidroksibenzoat%2C+trifeniltimah(IV)+4-+hidroksibenzoat%2C+antimalaria%2C+Plasmodium+falciparum%2C+nilai+IC50%0D%0A+%0D%0A%0D%0AABSTRACT%0D%0A%0D%0AIn+this+research%2C+synthesis+of+triphenyltin(IV)+2-hydroxybenzoate+and+triphenyltin(IV)+4-hydroxybenzoate+compound+by+reacting+triphenyltin(IV)+chloride+and+NaOH+compound+resulted+triphenyltin(IV)+hydroxide+compound.+Furthermore%2C+triphenyltin(IV)+hydroxide+was+reacted+with+2-hydroxybenzoic+acid+and+4-hydroxybenzoate+acid+with+a+weight+of+79.39%25+and+89.26%25.+The+result+of+synthesized+were+characterized+using++IR%2C+UV-Vis%2C+NMR+spectrophotometers%2C+and+microelemental+analyzer+showed+that+the+compounds+was+pure.+The+antimalarials+test+++to+++Plasmodium+++falciparum+parasite+++showed+++that+++triphenyltin(IV)+++4-+hydroxybenzoate++more++effective++than++trifenyltin(IV)++2-hydroxybenzoate++with+IC50+values+of+each+of+3.55+mg+%2F+mL+and+9.01+mg+%2F+mL.+These+two+compounds+are+classified+as+highly+active+compound+as+an+antimalarial+as+having+IC+50+values+%E2%89%A450+mg%2FmL.++However%2C+when+the+compounds+was+compared+with+++chloroquine+as+a+positive+control%2C+antimalarial+activity+of+this+compound+is+less+effective+than+chloroquine+which+has+IC50+values+of+0.002+mg+%2F+mL.%0D%0A%0D%0A%0D%0A%0D%0AKeywords%3A+Synthesis%2C+triphenyltin(IV)+2-hydroxybenzoate%2C+triphenyltin(IV)+4-+hydroxybenzoate%2C+antimalarial%2C+Plasmodium+falciparum%2C+the+value+IC50%0D%0A&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2017-07-11&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F27390%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F27390%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F27390%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++FEBRI+ARDHIYANSYAH%2C+1317011023++(2017)+SINTESIS%2C+KARAKTERISASI%2C+DAN+UJI+BIOAKTIVITAS+SENYAWA+TRIFENILTIMAH(IV)+2-+DAN+4-+HIDROKSIBENZOAT+TERHADAP+PARASIT+Plasmodium+falciparum+SECARA+IN+VITRO.++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F27390%2F