?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PEMBUATAN+MIKROPARTIKEL+POLI+ASAM+LAKTAT+(PAL)+SEBAGAI+SISTEM+PENGHANTAR+OBAT+(DRUG+DELIVERY)&rft.creator=Aulia+Pertiwi+Tri+Yuda%2C+1317011007&rft.subject=Q+Science+(General)&rft.subject=QD+Chemistry&rft.description=Pada+penelitian+ini+telah+dilakukan+pembuatan+mikropartikel+poli+asam+laktat+(PAL)+dengan+metode+penguapan+pelarut.+Proses+pembuatan+mikropartikel+poli+asam+laktat+menghasilkan+6%2C60+gram+dari+10+gram+sampel+dengan+ukuran+partikel+dalam+rentang+0%2C19-2%2C42+%CE%BCm+dengan+persentase+sebesar+90%25.+Mikropartikel+poli+asam+laktat+yang+dihasilkan+selanjutnya+digunakan+sebagai+aplikasi+sistem+penghantar+obat+dengan+variasi+obat+(0%2C15%3B+0%2C25%3B+dan+0%2C50)+gram.+Karakterisasi+FTIR%2C+menunjukkan+tidak+adanya+perubahan+gugus+fungsi+mikropartikel+poli+asam+laktat+setelah+dijadikan+sebagai+pengungkung+obat.+Analisis+SEM+menunjukkan+morfologi+mikropartikel+poli+asam+laktat+yang+berbentuk+lembaran+yang+halus+dan+berongga+dari+morfologi+poli+asam+laktat.+Sedangkan+enkapsulasi+obat+memiliki+morfologi+berbentuk+bulat+dengan+tonjolan+halus+tidak+beraturan+yang+tersebar+keseluruh+permukaan.+Uji+efisiensi+tertinggi+sebesar+59%25.+Berdasarkan+uji+disolusi+obat+pada+cairan+usus+(pH+7%2C4)+memiliki+persentase+sebesar+15%2C3%25+lebih+tinggi+dibandingkan+dalam+cairan+lambung+(pH+1%2C2)+hanya+sebesar+13%2C7%25+sehingga+enkapsulasi+obat+dengan+bahan+penyalut+miropartikel+poli+asam+laktat+dapat+menahan+laju+pelepasan+di+lambung.%0D%0AKata+Kunci+%3A+Mikropartikel+Poli+Asam+Laktat%2C+Metode+Penguapan+Pelarut%2C+Enkapsulasi%2C+Uji+Efisiensi%2C+dan+Uji+Disolusi%0D%0A%0D%0AABSTRACT%0D%0A%0D%0AThe+research+had+been+done+with+solvent+evaporation+method.+The+making+process+of+poly+lactic+acid+microparticles+yields+6.60+grams+of+10+grams+of+sample+with+a+particle+size+in+a+range+of+0.19-2.42+%CE%BCm+with+a+percentage+of+90%25.+The+result+poly+lactic+acid+microparticles+were+subsequently+used+as+an+application+of+drug+delivery+systems+with+drug+variations+(0.15%2C+0.25%2C+and+0.50)+grams.+FTIR+characterization%2C+showed+no+change+of+functional+group+of+poly+lactic+acid+microparticles+after+serving+as+drug+confinement.+SEM+analysis+showed+the+morphology+of+poly+lactic+acid+microparticles+in+the+form+of+a+smooth+and+hollow+sheet+of+poly+lactic+acid.+Meanwhile%2C+the+drug+encapsulation+has+a+spherical+morphology+with+irregular+smooth+bulges+scattered+throughout+the+surface.+The+highest+efficiency+test+was+59%25.+Based+on+the+drug+dissolution+test+on+intestinal+fluid+(pH+7.4)+has+a+percentage+of+15.3%25+higher+than+in+gastric+fluid+(pH+1.2)+of+only+13.7%25+so+the+drug+encapsulation+with+a+microparticles+poly+lactic+acid+coating+agent+can+withstand+the+rate+release+in+the+stomach.%0D%0AKeyword+%3A+Poly+Lactic+Acid+Microparticles%2C+Solvent+Evaporation+Method%2C%0D%0AEncapsulation%2C+Efficiency+Test%2C+and+Dissolution+Test&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2017-09-27&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F28630%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F28630%2F3%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F28630%2F2%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++Aulia+Pertiwi+Tri+Yuda%2C+1317011007++(2017)+PEMBUATAN+MIKROPARTIKEL+POLI+ASAM+LAKTAT+(PAL)+SEBAGAI+SISTEM+PENGHANTAR+OBAT+(DRUG+DELIVERY).++FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F28630%2F