?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=VARIASI+GENETIK+GEN+Plasmodium+falciparum+MEROZOIT+SURFACE%0D%0APROTEIN-1+(PFMSP-1)+DARI+PENDERITA+MALARIA+DI+WILAYAH+KERJA+PUSKESMAS+HANURA%2C+PESAWARAN%2C+LAMPUNG&rft.creator=ADE+TRIAJAYANTI%2C+(1418011002)&rft.subject=Q+Science+(General)&rft.description=Latar+Belakang%3A+Kejadian+malaria+baik+di+Indonesia+maupun+dunia+masih+menjadi+permasalahan+kesehatan.+Telah+ditemukan+kejadian+kekebalan+terhadap+pengobatan+malaria%2C+salah+satu+kemungkinan+penyebabnya+adalah+faktor+genetik.+Perubahan+yang+terjadi+pada+gen+Plasmodium+falciparum+menimbulkan+variasi+genetik+sehingga+menyebabkan+kekebalan+terhadap+pengobatan.+Terdapat+gen+dengan+polimorfisme+yang+dapat+dijadikan+sebagai+penanda+variasi+genetik+pada+Plasmodium+falciparum%2C+yaitu+gen+Plasmodium+falciparum+merozoit+surface+protein+1+(PFMSP-1).%0D%0AMetode%3A+Metode+deskriptif+dengan+pendekatan+survei+morbiditas+digunakan+pada+penelitian+ini.+Sampel+penelitian+adalah+23+BBT+yang+telah+diambil+pada+tahun+2016+dari+penderita+malaria+di+wilayah+kerja+Puskesmas+Hanura%2C+Pesawaran%2C+Lampung%2C+dengan+metode+consecutive+sampling.+Identifikasi+variasi+genetik+gen+PFMSP-1+dilakukan+dengan+cara+nested+PCR+di+Laboratorium+Biomolekular+FK+Unila.+Hasil+dari+penelitian+ini+diolah+menggunakan+perangkat+lunak+komputer.%0D%0AHasil%3A+Sejumlah+23+sampel+berhasil+dilakukan+nested+PCR+dengan+hasil+identifikasi+69+sampel+dari+seluruh+alel+gen+PFMSP-1.+Alel+dominan+yang+ditemukan+adalah+MAD20+(86%2C96%25)+dengan+empat+jenis+band.+Infeksi+dua+alel+ditemukan+pada+variasi+MAD20-K1+dan+MAD20-RO33%2C+sebanyak+satu+sampel.%0D%0AKesimpulan%3A+Terdapat+variasi+genetik+gen+PFMSP-1+pada+wilayah+kerja+Puskesmas+Hanura%2C+Pesawaran%2C+Lampung+dengan+alel+dominan+yaitu+MAD20.%0D%0AKata+Kunci%3A+MAD20%2C+PFMSP-1%2C+Variasi+genetik.%0D%0A%0D%0A%0D%0A%0D%0Aabstract%0D%0A%0D%0ABackground%3A+The+incidence+of+malaria+still+become+Indonesia+even+world+health+problem.+There+has+been+found+resistance+for+malaria+treatment%2C+and+one+of+the+possible+cause+is+genetic+factors.+The+changes+that+occur+in+the+Plasmodium+falciparum+gene+cause+genetic+variations+that+lead+to+resistance+for+treatment.+There+is+a+gene+with+polymorphism+that+can+be+used+as+a+marker+of+genetic+variation+in+Plasmodium+falciparum%2C+which+is+Plasmodium+falciparum+Merozoite+Protein+Surface+1+(PFMSP-1).%0D%0AMethods%3A+Descriptive+method+with+morbidity+survey+approach+used+in+this+study.+The+study+sample+was+23+BBT+which+taken+in+2016+from+malaria+patient+in+Puskesmas+Hanura%2C+Pesawaran%2C+Lampung%2C+by+consecutive+sampling.+Identification+of+genetic+variance+of+the+PFMSP-1+gene+was+performed+by+nested+PCR+at+Laboratorium+Biomolekular+FK+Unila.+The+results+of+this+study+were+processed+using+a+computer+software.%0D%0AResults%3A+There+is+23+samples+that+successfully+performed+with+nested+PCR+and+the+results+of+identification+from+the+entire+PFMSP-1+gene+allele+is+69+samples.+The+dominant+allele+that+found+is+MAD20+(86.96%25)+with+four+band+types.+Infection+of+two+alleles+were+found+in+variation+of+MAD20-KI+and+MA20-RO33+only+in+one+sample.%0D%0AConclusions%3A+There+are+genetic+variation+of+PFMSP-1+gene+found+in+territorty+of+Puskesmas+Hanura%2C+Pesawaran%2C+Lampung+with+the+dominant+alleles+is+MAD20.%0D%0AKeywords%3A+Genetic+variation%2C+MAD20%2C+PFMSP-1.&rft.publisher=UNIVERSITAS+LAMPUNG&rft.date=2018-01-12&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F29909%2F1%2FABSTRAK%2520%2528INGGRIS%2520%2526%2520INDONESIA%2529.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F29909%2F2%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F29909%2F3%2FSKRIPSI%2520FULL.pdf&rft.identifier=++ADE+TRIAJAYANTI%2C+(1418011002)++(2018)+VARIASI+GENETIK+GEN+Plasmodium+falciparum+MEROZOIT+SURFACE+PROTEIN-1+(PFMSP-1)+DARI+PENDERITA+MALARIA+DI+WILAYAH+KERJA+PUSKESMAS+HANURA%2C+PESAWARAN%2C+LAMPUNG.++UNIVERSITAS+LAMPUNG%2C+FAKULTAS+KEDOKTERAN.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F29909%2F