?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=EFEK+PEMBERIAN+EKSTRAK+METANOL+DAUN+Clerodendrum+inerme%0D%0ARUMPUT+LAUT+(Eucheuma+cottonii+L.)+DAN+TAURIN+TERHADAP%0D%0ARESPON+HISTOPATOLOGI+HEPAR+MENCIT+(Mus+musculus+L.)%0D%0A%0D%0AYANG+DIINDUKSI+BENZO(%CE%B1)PIREN&rft.creator=NOUFALLIA+FIKRI+ARRA%2C+1517021158&rft.subject=QH301+Biology&rft.description=Benzo(%CE%B1)pyrene+is+one+of+Polycyclic+Aromatic+Hydrocarbon+compund+that+highly%0D%0Apolluting+the+environment+and+can+induce+liver+carcinogenesis.+Extract+of%0D%0AClerodendrum+inerme+L.+and+seaweed+(Eucheuma+cottonii+L.)+also+taurine+are%0D%0Areported+showing+antioxidant+and+anticancer+activity.+This+study+aims+to%0D%0Ainvestigate+the+effect+of+methanol+extract+of+C.+inerme+L.+leaves%2C+seaweed+(E.%0D%0Acottonii+L.)+and+taurine+on+liver+histopathology+of+mice+that+induced+by%0D%0Abenzo(%CE%B1)pyrene.+This+study+was+conducted+using+a+Completely+Randomized%0D%0ADesign+(CRD)+with+5+treatment+groups+which+consisting+of+%3A+K1+(negative%0D%0Acontrols)%2C+K2+(induced+by+benzo(%CE%B1)pyrene+0%2C3+mg%2Fbw%2Fday+for+10+days%2C+K3+(given%0D%0AC.+inerme+leaves+extract+10%2C5+mg%2Fbw%2Fday+for+15+days+after+induced+by%0D%0Abenzo(%CE%B1)pyrene)%2C+K4+(given+E.+cottonii+L.+extract+14%2C7+mg%2Fbw%2Fday+for+15+days%0D%0Aafter+induced+by+benzo(%CE%B1)pyrene)+and+K5+(given+taurine+15%2C6+mg%2Fbw%2Fday+for+15%0D%0A%0D%0Aiii%0D%0Adays+after+induced+by+benzo(%CE%B1)pyrene)+with+5+replications+each+group.+The%0D%0Ainduction+of+benzo(%CE%B1)+pyrene+is+carried+out+subcutaneously.+The+parameters%0D%0Aobserved+were+body+weight%2C+erythrocyte+and+leukocyte+count%2C+leukocyte+cell%0D%0Adifferential%2C+liver+gross+weight%2C+liver+index+value%2C+and+liver+histopathology.+The%0D%0Adata+were+analyzed+statistically+using+One+Way+ANOVA+(p+%3C0.05%25)+and+LSD%0D%0A(Least+Significant+Difference)+test+at+5%25+significant+level.+The+result+showed+that%0D%0Aadministration+of+C.+inerme+L.+leaves+and+E.+cottonii+L.+methanol+extract+and%0D%0Ataurine+on+mice+that+induced+by+benzo(%CE%B1)pyrene+can+maintain+leukocyte+count%2C%0D%0Ainfluence+leukocyte+differential%2C+and+provide+hepatoprotective+effect+which+is%0D%0Ashown+in+liver+histopathology+of+mice%2C+with+the+highest+effect+in+order+are+shown%0D%0Aby+taurine%2C+C.+inerme+L.%2C+then+seaweed+(E.+cottonii+L.)%0D%0A%0D%0AKeyword+%3A+benzo(%CE%B1)pyrene%2C+Clerodendrum+inerme+L.%2C+liver+histopathology%2C+Mus%0D%0Amusculus%2C+seaweed+(Eucheuma+cottonii+L.)%2C+taurine%0D%0ABenzo(%CE%B1)piren+merupakan+salah+satu+senyawa+dari+kelompok+Polisiklik+Aromatik%0D%0AHidrokarbon+(PAH)+yang+banyak+mencemari+lingkungan+dan+berpotensi+memicu%0D%0Akarsinogenesis+pada+sel+hepar.+Ekstrak+dari+Clerodendrum+inerme+L.+dan+rumput%0D%0Alaut+serta+taurin+diduga+memiliki+aktivitas+antioksidan+dan+antikanker.+Tujuan%0D%0Apenelitian+ini+yaitu+untuk+menguji+efek+dari+ekstrak+metanol+daun+C.+inerme+L.%2C%0D%0Arumput+laut+(E.+cottonii+L.)+dan+taurin+terhadap+respon+histopatologi+hepar+dari%0D%0Amencit+(Mus+musculus+L.)+yang+diinduksi+benzo(%CE%B1)piren.+Penelitian+ini+dilakukan%0D%0Amenggunakan+Rancangan+Acak+Lengkap+(RAL)+dengan+5+kelompok+perlakuan%0D%0Ayang+terdiri+dari+K1+(kontrol+negatif)%2C+K2(diinduksi+benzo(%CE%B1)piren+0%2C3+mg%2FBB%2Fhari%2C%0D%0AK3+(diberikan+ekstrak+metanol+daun+C.+inerme+10%2C5+mg%2FBB%2Fhari+selama+15+hari%0D%0Asetelah+induksi+benzo(%CE%B1)piren+0%2C3+mg%2FBB%2Fhari)%2C+K4+(diberikan+ekstrak+metanol+E.%0D%0Acottonii+L.+14%2C7+mg%2FBB%2Fhari+setelah+induksi+benzo(%CE%B1)piren+0%2C3+mg%2FBB%2Fhari)+dan%0D%0AL.%2C%0D%0A%0D%0Av%0D%0AK5+(diberi+taurin+15%2C6+mg%2FBB%2Fhari+selama+15+hari+setelah+induksi+benzo(%CE%B1)piren%0D%0A0%2C3+mg%2FBB%2Fhari).+Induksi+senyawa+benzo(%CE%B1)piren+dilakukan+secara+subkutan.%0D%0AParameter+yang+diamati+yaitu+rerata+berat+badan%2C+jumlah+eritrosit+dan+leukosit%2C%0D%0Adifferensial+sel+leukosit%2C+rerata+berat+basah+organ+hepar%2C+rerata+nilai+indeks+organ%0D%0Ahepar%2C+dan+gambaran+histopatologi+sel+hepar.+Analisa+data+dilakukan%0D%0Amenggunakan+One+Way+ANOVA+pada+taraf+nyata+5%25+(p%3C0.05%25)+dan+uji+lanjut%0D%0ABNT+(Beda+NyataTerkecil)+pada+taraf+nyata+5%25.+Pemberian+ekstrak+metanol+daun%0D%0AClerodendrum+inerme+L.%2C+rumput+laut+(Eucheuma+cottonii+L.)+dan+taurin+pada%0D%0Amencit+yang+diinduksi+benzo(%CE%B1)piren+dapat+mempertahankan+jumlah+leukosit+dan%0D%0Amempengaruhi+diferensial+leukosit%2C+serta+memberikan+efek+hepatoprotektif+yang%0D%0Aditunjukkan+pada+histopatologi+hepar+mencit%2C+dengan+urutan+yang+paling+tinggi%0D%0Ayaitu+taurin%2C+daun+Clerodendrum+inerme+L.%2C+lalu+rumput+laut+(Eucheuma+cottonii%0D%0AL.)%0D%0A%0D%0AKata+kunci+%3A+benzo(%CE%B1)piren%2C+Clerodendrum+inerme+L.%2C+histopatologi+hepar%2C+Mus%0D%0Amusculus+L.%2C+rumput+laut+(Eucheuma+cottonii+L.)%2C+taurin&rft.publisher=FAKULTAS+MATEMATIKA+DAN+ILMU+PENGETAHUAN+ALAM&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55483%2F1%2FABSTRAK.pdf&rft.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