@misc{eprints55911,
           title = {PENGARUH PEMBERIAN MINUMAN RINGAN BERKARBONASI
TERHADAP PERUBAHAN HISTOPATOLOGI LAMBUNG TIKUS
PUTIH (Rattus norvegicus) JANTAN GALUR Sprague dawley},
          author = {1511011072 WULAN ALAWIYAH JAHRA},
         address = {UNIVERSITAS LAMPUNG},
       publisher = {FAKULTAS KEDOKTERAN},
            year = {2019},
             url = {http://digilib.unila.ac.id/55911/},
        abstract = {Background: Carbonated soft drink is classified as a non-alcoholic type of
beverages which gone through carbonation prosses with additions of caffein and
phosporic acid. Increasing in the consumption of carbonated soft drink already
happening for the last two decades. Based on 88 meta-analytical studies, it shows
that consumption of carbonated soft drink may lead into several health issues, for
examples an effect on gastrointestinal.
Objective: The aim of this research is to observ any changes that might happened

in gastric histopathological of white male rats (Rattus norvegicus) with Sprague-
dawley strain because of the consumption of carbonated soft drink.

Method: Quasi experimental research was done with randomized controlled
method using post test only control group design. 24 white male rats (Rattus
norvegicus) with Sprague-dawley strain was divided into 4 groups, consist of
control group (K) which was given aquadest, treatment 1 group (P1) which was
given carbonated soft drink with 3 ml/200 g/day, treatment 2 group (P2) with 6
ml/200 g/day, treatment 3 group (P3) with 12 ml/200 g/day. Overall research was
observed for 30 days.
Result: Average score of damage in gastric mucosa obtained using One Way
ANOVA test with p=0.00 was 0.17 for control group, 0.7 for P1 group, 1.07 for
P2 group, and 1.53 for P3 group. The test was followed by post hoc LSD test
which resulted signifficant difference for all type of groups (p{\ensuremath{<}}0.05).
Conclusion: There is a significant difference of carbonated soft drink
consumption into white male rats (Rattus norvegicus) of Sprague-dawley strain
gastric histopathological changes.

Keywords: Carbonated soft drink, gastric histopathological, effect on

gastrointestinal, white rats.
Latar Belakang: Minuman ringan berkarbonasi adalah minuman non-alkohol
yang mengalami proses karbonasi dengan tambahan zat seperti kafein dan asam
fosfat. Pada dua dekade terakhir telah terjadi peningkatan konsumsi minuman
berkarbonasi di dunia. Delapan puluh delapan studi meta-analisis menunjukan
bahwa konsumsi minuman ringan berkarbonasi dapat menimbulkan masalah
kesehatan seperti efek gastrointestinal.
Tujuan: Penelitian ini bertujuan untuk mengetahui apakah minuman ringan
berkarbonasi dapat mempengaruhi perubahan histopatologi lambung tikus putih
(Rattus norvegicus) jantan galur Sprague dawley.
Metode: Jenis penelitian kuasi eksperimental metode rancangan acak terkontrol
menggunakan post test only control group designs. Sampel terdiri dari 24 ekor
tikus putih jantan galur Sprague dawley, dibagi menjadi 4 kelompok: kelompok
kontrol (K) hanya diberi aquades, perlakuan 1 (P1) diberi minuman ringan
berkarbonasi dengan dosis 3 ml/200 gr/hari, perlakuan 2 (P2) 6 ml/200 gr/hari,
dan perlakuan 3 (P3) dengan dosis 12 ml/200 gr/hari diberikan selama 30 hari.
Hasil: Rerata skor kerusakan mukosa lambung pada kelompok K:0,17, P1:0,7,
P2:1,07, dan P3:1,53. Data yang diperoleh diuji menggunakan One Way ANOVA
didapatkan penelitian bermakna p=0,00, dilanjutkan dengan post hoc LSD
didapatkan perbedaan bermakna pada semua kelompok (p{\ensuremath{<}}0,05).
Simpulan: Terdapat pengaruh pemberian minuman ringan berkarbonasi terhadap
perubahan histopatologi lambung tikus putih (Rattus norvegicus) jantan galur
Sprague dawley.

Kata Kunci: Minuman ringan berkarbonasi, histopatologi lambung, efek gastro

intestinal, tikus putih.}
}