?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=PENGARUH+PEMBERIAN+MINUMAN+RINGAN+BERKARBONASI%0D%0ATERHADAP+PERUBAHAN+HISTOPATOLOGI+LAMBUNG+TIKUS%0D%0APUTIH+(Rattus+norvegicus)+JANTAN+GALUR+Sprague+dawley&rft.creator=WULAN+ALAWIYAH+JAHRA%2C+1511011072&rft.subject=610+Ilmu+kedokteran%2C+ilmu+pengobatan+dan+ilmu+kesehatan&rft.description=Background%3A+Carbonated+soft+drink+is+classified+as+a+non-alcoholic+type+of%0D%0Abeverages+which+gone+through+carbonation+prosses+with+additions+of+caffein+and%0D%0Aphosporic+acid.+Increasing+in+the+consumption+of+carbonated+soft+drink+already%0D%0Ahappening+for+the+last+two+decades.+Based+on+88+meta-analytical+studies%2C+it+shows%0D%0Athat+consumption+of+carbonated+soft+drink+may+lead+into+several+health+issues%2C+for%0D%0Aexamples+an+effect+on+gastrointestinal.%0D%0AObjective%3A+The+aim+of+this+research+is+to+observ+any+changes+that+might+happened%0D%0A%0D%0Ain+gastric+histopathological+of+white+male+rats+(Rattus+norvegicus)+with+Sprague-%0D%0Adawley+strain+because+of+the+consumption+of+carbonated+soft+drink.%0D%0A%0D%0AMethod%3A+Quasi+experimental+research+was+done+with+randomized+controlled%0D%0Amethod+using+post+test+only+control+group+design.+24+white+male+rats+(Rattus%0D%0Anorvegicus)+with+Sprague-dawley+strain+was+divided+into+4+groups%2C+consist+of%0D%0Acontrol+group+(K)+which+was+given+aquadest%2C+treatment+1+group+(P1)+which+was%0D%0Agiven+carbonated+soft+drink+with+3+ml%2F200+g%2Fday%2C+treatment+2+group+(P2)+with+6%0D%0Aml%2F200+g%2Fday%2C+treatment+3+group+(P3)+with+12+ml%2F200+g%2Fday.+Overall+research+was%0D%0Aobserved+for+30+days.%0D%0AResult%3A+Average+score+of+damage+in+gastric+mucosa+obtained+using+One+Way%0D%0AANOVA+test+with+p%3D0.00+was+0.17+for+control+group%2C+0.7+for+P1+group%2C+1.07+for%0D%0AP2+group%2C+and+1.53+for+P3+group.+The+test+was+followed+by+post+hoc+LSD+test%0D%0Awhich+resulted+signifficant+difference+for+all+type+of+groups+(p%3C0.05).%0D%0AConclusion%3A+There+is+a+significant+difference+of+carbonated+soft+drink%0D%0Aconsumption+into+white+male+rats+(Rattus+norvegicus)+of+Sprague-dawley+strain%0D%0Agastric+histopathological+changes.%0D%0A%0D%0AKeywords%3A+Carbonated+soft+drink%2C+gastric+histopathological%2C+effect+on%0D%0A%0D%0Agastrointestinal%2C+white+rats.%0D%0ALatar+Belakang%3A+Minuman+ringan+berkarbonasi+adalah+minuman+non-alkohol%0D%0Ayang+mengalami+proses+karbonasi+dengan+tambahan+zat+seperti+kafein+dan+asam%0D%0Afosfat.+Pada+dua+dekade+terakhir+telah+terjadi+peningkatan+konsumsi+minuman%0D%0Aberkarbonasi+di+dunia.+Delapan+puluh+delapan+studi+meta-analisis+menunjukan%0D%0Abahwa+konsumsi+minuman+ringan+berkarbonasi+dapat+menimbulkan+masalah%0D%0Akesehatan+seperti+efek+gastrointestinal.%0D%0ATujuan%3A+Penelitian+ini+bertujuan+untuk+mengetahui+apakah+minuman+ringan%0D%0Aberkarbonasi+dapat+mempengaruhi+perubahan+histopatologi+lambung+tikus+putih%0D%0A(Rattus+norvegicus)+jantan+galur+Sprague+dawley.%0D%0AMetode%3A+Jenis+penelitian+kuasi+eksperimental+metode+rancangan+acak+terkontrol%0D%0Amenggunakan+post+test+only+control+group+designs.+Sampel+terdiri+dari+24+ekor%0D%0Atikus+putih+jantan+galur+Sprague+dawley%2C+dibagi+menjadi+4+kelompok%3A+kelompok%0D%0Akontrol+(K)+hanya+diberi+aquades%2C+perlakuan+1+(P1)+diberi+minuman+ringan%0D%0Aberkarbonasi+dengan+dosis+3+ml%2F200+gr%2Fhari%2C+perlakuan+2+(P2)+6+ml%2F200+gr%2Fhari%2C%0D%0Adan+perlakuan+3+(P3)+dengan+dosis+12+ml%2F200+gr%2Fhari+diberikan+selama+30+hari.%0D%0AHasil%3A+Rerata+skor+kerusakan+mukosa+lambung+pada+kelompok+K%3A0%2C17%2C+P1%3A0%2C7%2C%0D%0AP2%3A1%2C07%2C+dan+P3%3A1%2C53.+Data+yang+diperoleh+diuji+menggunakan+One+Way+ANOVA%0D%0Adidapatkan+penelitian+bermakna+p%3D0%2C00%2C+dilanjutkan+dengan+post+hoc+LSD%0D%0Adidapatkan+perbedaan+bermakna+pada+semua+kelompok+(p%3C0%2C05).%0D%0ASimpulan%3A+Terdapat+pengaruh+pemberian+minuman+ringan+berkarbonasi+terhadap%0D%0Aperubahan+histopatologi+lambung+tikus+putih+(Rattus+norvegicus)+jantan+galur%0D%0ASprague+dawley.%0D%0A%0D%0AKata+Kunci%3A+Minuman+ringan+berkarbonasi%2C+histopatologi+lambung%2C+efek+gastro%0D%0A%0D%0Aintestinal%2C+tikus+putih.&rft.publisher=FAKULTAS+KEDOKTERAN&rft.date=2019&rft.type=Skripsi&rft.type=NonPeerReviewed&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55911%2F1%2FABSTRAK.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55911%2F2%2FSKRIPSI%2520FULL.pdf&rft.format=text&rft.identifier=http%3A%2F%2Fdigilib.unila.ac.id%2F55911%2F3%2FSKRIPSI%2520TANPA%2520BAB%2520PEMBAHASAN.pdf&rft.identifier=++WULAN+ALAWIYAH+JAHRA%2C+1511011072++(2019)+PENGARUH+PEMBERIAN+MINUMAN+RINGAN+BERKARBONASI+TERHADAP+PERUBAHAN+HISTOPATOLOGI+LAMBUNG+TIKUS+PUTIH+(Rattus+norvegicus)+JANTAN+GALUR+Sprague+dawley.++FAKULTAS+KEDOKTERAN%2C+UNIVERSITAS+LAMPUNG.+++++&rft.relation=http%3A%2F%2Fdigilib.unila.ac.id%2F55911%2F